Ragweed Reagins in Nasal Secretion.

Samter, Max; Becker, Elmer L.

doi:10.3181/00379727-65-15891p

Cited by 30 publications

(15 citation statements)

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“…6) were generally a little above 1.0 for both groups, but no marked changes in different situations similar to those seen for IgA were observed. ter paper [16,19,25] into the nasal cavi ties. The increase in weight of the intro duced material has been measured to give an idea of the amount of secretion collected.…”

Section: Resultsmentioning

confidence: 99%

Immunoglobulins in Nasal Secretion with Special Reference to IgE

Johansson¹,

Deuschl²

1976

Int Arch Allergy Immunol

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Different ways of collecting relatively large volumes of nasal secretion with as physiological a composition as possible were studied. Nasal secretion was collected by the so-called nasal spray washing method from 5 patients with allergic rhinitis due to pollen and 5 healthy persons during a pollen-free season. The collection was performed without any provocation and following nasal provocation with histamine or allergen solution. With the radioimmunosorbent test, in which the lower limit of measurement was 0.1 units/ml, IgE could be quantified in 52 of 60 analysed secretions. IgA, IgG and albumin were demonstrated in all secretions. In the allergic patients, following histamine and allergen provocation, a relative increase in the concentration of IgE and albumin and a significant decrease of the IgA/albumin ratio in nasal secretion was found. In the healthy subjects, such changes in the secretion were observed only after histamine provocation. Calculations also suggested some local production of IgE, but not at all of the same order of magnitude as of IgA.

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Section: Resultsmentioning

confidence: 99%

Immunoglobulins in Nasal Secretion with Special Reference to IgE

Johansson¹,

Deuschl²

1976

Int Arch Allergy Immunol

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“…The former method caused an outpouring of serum proteins (Figure 7) probably representing a response to local irritation and injury due to the foreign body or hypertonic solution, or both. Nasal secretions collected using such methods cannot be considered physiological, and the finding of antibodies in the secretions would not be surprising (32).…”

Section: Methodsmentioning

confidence: 99%

Serum Proteins and Antibody Activity in Human Nasal Secretions *

Remington¹,

Vosti²,

Lietze³

et al. 1964

J. Clin. Invest.

114

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“…Other investigators [3,4,18,[20][21][22] have found anti bodies to ragweed associated with immunoglobulins G, M, A and E in na sal secretions. One might assume that inhaled ragweed pollen antigens bind with the antibodies present in the nasal mucosa of ragweed-sensitive individuals forming antigen-antibody complexes.…”

Section: Discussionmentioning

confidence: 99%

Antigen-Antibody Complexes in or on Eosinophils in Nasal Secretions

Fujita

Rubinstein

Greco

et al. 1975

Int Arch Allergy Immunol

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The presence of IgE, IgG and ragweed antigen in or on eosinophils in the nasal secretions of ragweed-sensitive patients was investigated by radioautography using specifically purified ¹²⁵I-labelled antibodies to the above substances. The results indicate a significant (p <0.001) uptake of antiragweed antibody and anti-IgE antibody by eosinophils. There was no evidence of significant uptake of anti-IgG. From the above findings it was postulated that during the pollination season exposure to ragweed leads to the formation of ragweed-IgE antibody complexes. This is followed by the infiltration of eosinophils into the local tissue and the subsequent phagocytosis of these antigen-antibody complexes by the eosinophils.

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Ragweed Reagins in Nasal Secretion.

Cited by 30 publications

References 0 publications

Immunoglobulins in Nasal Secretion with Special Reference to IgE

Immunoglobulins in Nasal Secretion with Special Reference to IgE

Serum Proteins and Antibody Activity in Human Nasal Secretions *

Antigen-Antibody Complexes in or on Eosinophils in Nasal Secretions

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