This study looked at the temperature variations in West Africa's Volta River Basin (VRB) from 2021 to 2050 in comparison to the historical period (1985–2014) under two Shared Socioeconomic Pathway Scenarios (SSP2-4.5 and SSP5-8.5). Datasets from three Global Climate Models (GCMs) of the sixth Coupled Model Intercomparison Project (CMIP6) were used. The GCMs and their ensemble were evaluated on a monthly scale. The ensemble mean was used to analyse the changes in the annual and monthly temperature over the Sahel, Savannah, Guinea Coast, and the entire Volta basin. The results show that the individual GCMs reproduced the observed temperature pattern at the VRB, though with some overestimations, and the ensemble mean indicated a better representation of the observed temperature. A warming trend in the basin is projected under both climate scenarios by the ensemble mean, with higher temperatures projected under SSP5-8.5 compared to SSP2-4.5 in all three zones. The mean annual temperature is projected to increase by 0.8 and 1.0 °C, with a statistically increasing trend under SSP2-4.5 and SSP5-8.5, respectively. Without a doubt, high temperatures, if unchecked, can erupt into resource conflict among the competing interest groups and also affect the achievement of economic development at the VRB.