Raised platelet levels in diabetes mellitus complicated with nephropathy

Sterner,; Carlson, '; Ekberg,

doi:10.1046/j.1365-2796.1998.00349.x

Cited by 12 publications

(13 citation statements)

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“…A higher platelet count could contribute to the formation of microthrombi and affect renal microcirculation. Sterner et al [20] have shown a significantly raised platelet count in type 1 diabetic patients with nephropathy, but this has not been previously reported in type 2 diabetes. It has been suggested that both the total number of platelets and their ability to aggregate could influence the microvascular circulation in DM and play a part in the progression of arteriosclerotic lesions [21].…”

Section: Discussionmentioning

confidence: 77%

Factors associated with diabetic nephropathy in subjects with proliferative retinopathy

et al. 2011

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Section: Discussionmentioning

confidence: 77%

Factors associated with diabetic nephropathy in subjects with proliferative retinopathy

et al. 2011

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“…Platelets in T2DM are characterized by dysregulation of several signaling pathways, and they can become hyperreactive and more prone to undesirable activation, adhesion, and aggregation (6)(7)(8)(9). Other abnormalities such as raised platelet count and high mean platelet volume (MPV) have also been observed in T2DM (10,11). Shilpi et al (12) showed that MPV (11.3 5 1.0 fL) in diabetics is significantly higher than the MPV (9.0 5 0.6 fL) in nondiabetics.…”

Section: Introductionmentioning

confidence: 99%

Quantifying Platelet Margination in Diabetic Blood Flow

Chang

Yazdani

et al. 2018

Biophysical Journal

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Patients with type 2 diabetes mellitus (T2DM) develop thrombotic abnormalities strongly associated with cardiovascular diseases. In addition to the changes of numerous coagulation factors such as elevated levels of thrombin and fibrinogen, the abnormal rheological effects of red blood cells (RBCs) and platelets flowing in blood are crucial in platelet adhesion and thrombus formation in T2DM. An important process contributing to the latter is the platelet margination. We employ the dissipative particle dynamics method to seamlessly model cells, plasma, and vessel walls. We perform a systematic study on RBC and platelet transport in cylindrical vessels by considering different cell shapes, sizes, and RBC deformabilities in healthy and T2DM blood, as well as variable flowrates and hematocrit. In particular, we use cellular-level RBC and platelet models with parameters derived from patient-specific data and present a sensitivity study. We find T2DM RBCs, which are less deformable compared to normal RBCs, lower the transport of platelets toward the vessel walls, whereas platelets with higher mean volume (often observed in T2DM) lead to enhanced margination. Furthermore, increasing the flowrate or hematocrit enhances platelet margination. We also investigated the effect of platelet shape and observed a nonmonotonic variation with the highest near-wall concentration corresponding to platelets with a moderate aspect ratio of 0.38. We examine the role of white blood cells (WBCs), whose count is increased notably in T2DM patients. We find that WBC rolling or WBC adhesion tends to decrease platelet margination due to hydrodynamic effects. To the best of our knowledge, such simulations of blood including all blood cells have not been performed before, and our quantitative findings can help separate the effects of hydrodynamic interactions from adhesive interactions and potentially shed light on the associated pathological processes in T2DM such as increased inflammatory response, platelet activation and adhesion, and ultimately thrombus formation.

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“…Sterner et al, observed a connection between raised platelet number and diabetic female gender. He also noted that diabetic nephropathy is related to platelet count and function, so platelet count might be a future prognostic indicator for diabetic complications, opening new study directions [11]. The indirect corelation between mean platelet volume and diabetes duration was not what we expected, since larger platelets are thought to be more active and thrombogenic than normal or smaller ones.…”

Section: Resultsmentioning

confidence: 72%

Determination of Platelet Parameters with Impedance Automated Analyzers in Diabetic Patients with Coronary Artery Disease

Apăvăloaie¹,

Bojan²,

Bădulescu³

et al. 2019

Rev. Chim.

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Atherosclerosis and platelet activity are two important chain factors linked together in the onset and the severity of coronary artery disease. Our study included 60 diabetic patients with ischemic heart disease, all having underwent coronary angiography. In this substudy from a larger epigenetical and genetical study, we phocused on the interrelationship between vessel disease and primary hemostasis. The haematological parameters included were platelet count (PLT), the platelet distribution width (PDW), the mean platelet volume (MPV) and the platelet larger cell ratio (P-LCR). ). The severity of the coronary disease was defined by the number of stenotic/occluded coronary arteries. We demonstrated a positive corelation with the duration of diabetes (p=0.032), as 34% of the patients with a long duration of the diabetes had a higher number of platelets. The mean platelet volume was slightly elevated in diabetic females over 65 years old, compared to younger diabetic men, though not statistically significant (p=0.101). Although the investigated parameters were mostly in the normal range, the fact that for some cathegories of patients they were orientated towards the upper limit, raises some questions for the next studies. Future adjustments of lot number and selection criteria for the following studies are needed. Using the MPV as a prediction test for cardiovascular complications is still a controversial subject, since the scientifical background contains both positive and negative studies on this matter.

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Raised platelet levels in diabetes mellitus complicated with nephropathy

Cited by 12 publications

References 1 publication

Factors associated with diabetic nephropathy in subjects with proliferative retinopathy

Factors associated with diabetic nephropathy in subjects with proliferative retinopathy

Quantifying Platelet Margination in Diabetic Blood Flow

Determination of Platelet Parameters with Impedance Automated Analyzers in Diabetic Patients with Coronary Artery Disease

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