Raised Serum Levels of Tumour Necrosis Factor in Parasitic Infections

Scuderi, Phillip E.; Lam, KitS.; Ryan, KennethJ.; Petersen, Eskild A.; Sterling, KarenE.; Finley, PaulR.; Ray, C. George; Slymen, DonaldJ.; Salmon, SydneyF.

doi:10.1016/s0140-6736(86)92007-6

Cited by 418 publications

(126 citation statements)

References 13 publications

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“…It is possible that the production of TNF may also have a role in the defence against infections. The activity of the material against parasites in vitro and the observation that serum TNF levels are elevated in some parasitic infections (Scuderi et al, 1986) would support this suggestion.…”

Section: Tnfmentioning

confidence: 75%

“…It has diverse biological effects in other experimental systems including killing of tumour cells in vitro (Old, 1985), inhibition of the activity of lipoprotein lipase (cachectin activity) (Beutler & Cerami, 1987); mediation of some of the lethal effects of endotoxin in animals (Beutler et al, 1985), stimulation of granulocytes and fibroblasts (Old, 1985;Beutler & Cerami, 1987;Vilcek et al, 1986), damage to endothelial cells (Sato et al, 1986), bone resorption (Bertolini et al, 1986), antiviral activity (Mestan et al, 1986;Wong & Goeddel, 1986) and cytotoxic effects against malarial parasites (Taverne et al, 1981(Taverne et al, ,1984. Raised serum TNF levels are associated with some infections in man (Scuderi et al, 1986;Waage et al, 1987). Macrophageproduced TNF (which we have studied) is sometimes referred to as TNF alph-a to distinguish it from lymphocytotoxin, a closely related lymphocyte-product which may be called TNF beta (Pennica et al, 1984).…”

mentioning

confidence: 99%

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Tumour necrosis factor in man: Clinical and biological observations

Selby

Hobbs²,

Viner³

et al. 1987

Br J Cancer

198

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Summary Eighteen patients with advanced cancer have been treated intravenously with human recombinant tumour necrosis factor (rhTNF). The drug produced febrile reactions at all doses although these were preventable by steroids and indomethacin. Doses at or above 9 x 105 units (400 pg)m-2 were associated with hypotension, abnormal liver enzymes, leucopenia and mild renal impairment in a substantial proportion of patients. RhTNF was cleared from plasma with a half life of -20 minutes but non-linear pharmacokinetics were seen with decreased clearance at higher doses. In 3 patients, all with lymphoma, improvements in their tumours were recorded.RhTNF was noted to produce rapid increases in serum C-reactive protein concentrations. Endogenous TNF levels were not found to be elevated in 72 cancer patients.TNF deserves further therapeutic evaluation and these observations support its biological importance as an endogenous pyrogen, mediator of acute phase protein responses, and a mediator of endotoxic shock.

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Section: Tnfmentioning

confidence: 75%

mentioning

confidence: 99%

Tumour necrosis factor in man: Clinical and biological observations

Selby

Hobbs²,

Viner³

et al. 1987

Br J Cancer

198

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“…TNF-K secretion was measured by modi¢cation of an enzymelinked immunosorbent assay (ELISA), as described earlier [23]. For the ELISA, 96-well plates were coated with 6.25 ng/well of murine monoclonal Ab with speci¢city for murine TNF-K. Before use and between subsequent steps in the assay, coated plates were washed twice with phosphate-buufered saline (PBS) containing 0.05% (v/v) Tween-20 and twice with PBS alone.…”

Section: Assay Of Tnf-k Secretionmentioning

confidence: 99%

Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF‐α secretion, and NF‐κB‐dependent gene expression in RAW 264.7 macrophages

et al. 2000

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Flavonoids are potent antioxidants and have been associated with lowering the risk of cardiovascular diseases. In this study, the effect of flavonoids (monomers, dimers and a trimer) as well as French maritime pine bark extract, Pycnogenol, on NO production, tumor necrosis factor-K K (TNF-K K) secretion and nuclear factor (NF)-U UB activity was compared. Monomers and dimers repressed NO production, TNF-K K secretion and NF-U UB-dependent gene expression induced by interferon Q Q, whereas the trimeric procyanidin C2 and Pycnogenol enhanced these parameters. In addition, in unstimulated RAW 264.7 macrophages, both procyanidin C2 and Pycnogenol increased TNF-K K secretion in a concentration-and timedependent manner. These results demonstrate that procyanidins act as modulators of the immune response in macrophages.z 2000 Federation of European Biochemical Societies.

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“…L'hypothèse est basée sur la capacité d'inhibition de la lipoprotéine lipase par le Tumor Necrosis Factor, augmentée pendant l'accès palustre (Scuderi et al, 1986;Beutler & Cérami, 1987;Semb et ai, 1987;Grau et al, 1989). …”

Section: Variations Dans Les Taux De Lipides Plasma-tiques En Fonctiounclassified

Variations dans les taux de lipides plasmatiques en fonction de l'infection àPlasmodium Falciparumà São Tomé

et al. 1996

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Changes in lipid plasma levels during malaria attacks have been proposed for use in diagnosis or to assess the severity of the disease. In order to analyse the plasma levels of cholesterol, triglycerides, HDL-C et LDL-C, we compared, in an endemic area (Sao Tome island), two groups of patients children infected with Plasmodium falciparum (simple malaria attack and cerebral malaria) with a control group of asymptomatic children. No correlation between lipid plasma levels and disease severity was found. Cortelations between lipids and parasitemia or anemia were analysed. The mechanism of plasma lipid changes during attack ate discussed.KEYWORDS : malaria, Plasmodium falciparum, cholesterol, triglycerides, HDL, LDL, anemia. Résumé : Les variations des niveaux des lipides plasmatiques pendant l'accès ont suggéré l'utilisation de leur dosage comme test diagnostique ou comme indicateur de la sévérité de la maladie. Dans le but d'évaluer le changement des cholestérol total (CT), triglycérides (TG), HDL-cholestérol (HDL-C) et LDL-cholestérol pendant l'accès palustre en région endémique (île de São Tomé), on a sélectionné deux groupes d'enfants infectés par

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Raised Serum Levels of Tumour Necrosis Factor in Parasitic Infections

Cited by 418 publications

References 13 publications

Tumour necrosis factor in man: Clinical and biological observations

Tumour necrosis factor in man: Clinical and biological observations

Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF‐α secretion, and NF‐κB‐dependent gene expression in RAW 264.7 macrophages

Variations dans les taux de lipides plasmatiques en fonction de l'infection àPlasmodium Falciparumà São Tomé

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