Raloxifene enhances peri-implant bone healing in osteoporotic rats

Ramalho-Ferreira, Gabriel; Faverani, Leonardo Pérez; Prado, Felippe Bevilacqua; Garcia, Idelmo Rangel; Okamoto, Roberta

doi:10.1016/j.ijom.2015.02.018

Cited by 51 publications

(44 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study of implant bioactivity in low-quality bone tissue, as performed in this research, is not related to the treatment of osteoporosis through medications that reverse this condition, such as anti-resorptive and selective estrogen receptor modulators (SERMs). Previous studies have shown that systemic treatment assisted in the molecular responses of bone tissue biology [36,44]. Thus, even in very critical bone metabolism situations, such as the OVX group, the PEO coating demonstrated reparative characteristics favorable to osseointegration.…”

Section: Discussionmentioning

confidence: 96%

Comparison between Plasma Electrolytic Oxidation Coating and Sandblasted Acid-Etched Surface Treatment: Histometric, Tomographic, and Expression Levels of Osteoclastogenic Factors in Osteoporotic Rats

Momesso

Santos

et al. 2020

Materials

View full text Add to dashboard Cite

Plasma electrolytic oxidation (PEO) has been a promising surface coating with better mechanical and antimicrobial parameters comparing to conventional treatment surfaces. This study evaluated the peri-implant bone repair using (PEO) surface coatings compared with sandblasted acid (SLA) treatment. For this purpose, 44 Wistar rats were ovariectomized (OVX-22 animals) or underwent simulated surgery (SS-22 animals) and received implants in the tibia with each of the surface coatings. The peri-implant bone subsequently underwent molecular, microstructural, bone turnover, and histometric analysis. Real-time PCR showed a higher expression of osteoprotegerin (OPG), receptor activator of nuclear kappa-B ligand (RANKL), and osteocalcin (OC) proteins in the SLA/OVX and PEO/SS groups (p < 0.05). Computed microtomography, confocal microscopy, and histometry showed similarity between the PEO and SLA surfaces, with a trend toward the superiority of PEO in OVX animals. Thus, PEO surfaces were shown to be promising for enhancing peri-implant bone repair in ovariectomized rats.

show abstract

Section: Discussionmentioning

confidence: 96%

Comparison between Plasma Electrolytic Oxidation Coating and Sandblasted Acid-Etched Surface Treatment: Histometric, Tomographic, and Expression Levels of Osteoclastogenic Factors in Osteoporotic Rats

Momesso

Santos

et al. 2020

Materials

View full text Add to dashboard Cite

show abstract

“…Next, Gel, Chi, Gel, BMP2 were also consecutively deposited on titanium substrates or rods with the same condition. The procedure was repeated until the desired multilayered films of [(Gel/Chi/Gel/CT)/(Gel/ Chi/Gel/BMP2)] 4 were deposited onto TC4 substrates, which were denoted as TC4/LBL/CT/BMP2. The TC4 substrates or rods modified only with Chi/Gel polyelectrolyte multilayers were denoted as TC4/LBL, and those functionalized with Chi/Gel polyelectrolyte multilayers containing the CT agent were denoted as TC4/LBL/CT.…”

Section: Fabrication and Characterization Of Polyelectrolyte Multilaymentioning

confidence: 99%

“…Especially for the patients with osteoporotic fractures, titanium implants were more prone to failure on account of the decreased bone mass and strength, altered microstructure, and reduced regenerative capacity of the patients . Previous study have confirmed that the osseointegration on the contact surface between an implant and bone tissue would be severely inhibited after implantation in osteoporotic animal models …”

Section: Introductionmentioning

confidence: 99%

“…3 Previous study have confirmed that the osseointegration on the contact surface between an implant and bone tissue would be severely inhibited after implantation in osteoporotic animal models. 4 Over the past few decades, major efforts have been devoted to improving the osseointegration through surface engineering of titanium and its alloys, thus to effectively cure the osteoporotic fractures. The typical strategies could be primarily divided into two types.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhancement of local bone remodeling in osteoporotic rabbits by biomimic multilayered structures on Ti6Al4V implants

Huang

Luo

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

To enhance long-term survival of titanium implants in patients with osteoporosis, chitosan/gelatin multilayers containing bone morphogenetic protein 2(BMP2) and an antiosteoporotic agent of calcitonin (CT) are deposited on the Ti6Al4V (TC4) implants through layer-by-layer (LBL) electrostatic assembly technique. Here, the obtained titanium alloy implant (TC4/LBL/CT/BMP2) can regulate the release of loaded calcitonin and BMP2 agents in a sustaining manner to accelerate the bone formation and simultaneously inhibit bone resorption. In vitro results show that the bone-related cells on TC4/LBL/CT/BMP2 present the lowest production level of tartrate resistant acid phosphatase (TRAP) but the highest (p < 0.05) level of alkaline phosphatase (ALP) activity, osteocalcin production, mineralization capacity and osteoblast-related gene expression among all groups after treatment for 7 or 21 days, respectively. Besides, in vivo studies of micro-CT analysis, routine histological and immunohistochemical analysis also collectively demonstrate that the TC4/LBL/CT/BMP2 implant can dramatically promote the formation and remodeling of new bone in osteoporotic rabbits after implantation for 30 days and 90 days, respectively. In vivo push-out testing further confirms that the TC4/LBL/CT/BMP2 implant has the highest (p < 0.01) interfacial shear strength and favorable bone-implant osseointegration. Overall, this study establishes a simple and profound methodology to fabricate a biofunctional TC4 implant for the treatment of local osteoporotic fractures in vivo. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1437-1451, 2016.

show abstract

“…[5][6][7] Over the course of the past few years, major strides have been made in TiO 2 -nanosystem surface modification, due to a lot of significant progress in electrochemistry, catalysis, energetics, and corrosion. [8][9][10] Many researchers have applied electrochemical anodization technique to create TiO 2 nanotubes or nanopores on the surface of biomaterials to stimulate cell proliferation, cell adhesion, or mineralization of osteoblasts in vitro, and have achieved some good results.…”

mentioning

confidence: 99%

The synergistic effect of TiO<sub>2</sub> nanoporous modification and platelet-rich plasma treatment on titanium-implant stability in ovariectomized rats

Jiang

et al. 2016

IJN

View full text Add to dashboard Cite

For several decades, titanium and its alloys have been commonly utilized for endosseous implantable materials, because of their good mechanical properties, chemical resistance, and biocompatibility. But associated low bone mass, wear and loss characteristics, and high coefficients of friction have limited their long-term stable performance, especially in certain abnormal bone-metabolism conditions, such as postmenopausal osteoporosis. In this study, we investigated the effects of platelet-rich plasma (PRP) treatment and TiO 2 nanoporous modification on the stability of titanium implants in osteoporotic bone. After surface morphology, topographical structure, and chemical changes of implant surface had been detected by scanning electron microscopy (SEM), atomic force microscopy, contact-angle measurement, and X-ray diffraction, we firstly assessed in vivo the effect of PRP treatment on osseointegration of TiO 2 -modified implants in ovariectomized rats by microcomputed tomography examinations, histology, biomechanical testing, and SEM observation. Meanwhile, the potential molecular mechanism involved in peri-implant osseous enhancement was also determined by quantitative real-time polymerase chain reaction. The results showed that this TiO 2 -modified surface was able to lead to improve bone implant contact, while PRP treatment was able to increase the implant surrounding bone mass. The synergistic effect of both was able to enhance the terminal force of implants drastically in biomechanical testing. Compared with surface modification, PRP treatment promoted earlier osteogenesis with increased expression of the RUNX2 and COL1 genes and suppressed osteoclastogenesis with increased expression of OPG and decreased levels of RANKL. These promising results show that PRP treatment combined with a TiO 2 -nanomodified surface can improve titanium-implant biomechanical stability in ovariectomized rats, suggesting a beneficial effect to support the success of implants in osteoporotic bone.

show abstract

Raloxifene enhances peri-implant bone healing in osteoporotic rats

Cited by 51 publications

References 28 publications

Comparison between Plasma Electrolytic Oxidation Coating and Sandblasted Acid-Etched Surface Treatment: Histometric, Tomographic, and Expression Levels of Osteoclastogenic Factors in Osteoporotic Rats

Comparison between Plasma Electrolytic Oxidation Coating and Sandblasted Acid-Etched Surface Treatment: Histometric, Tomographic, and Expression Levels of Osteoclastogenic Factors in Osteoporotic Rats

Enhancement of local bone remodeling in osteoporotic rabbits by biomimic multilayered structures on Ti6Al4V implants

The synergistic effect of TiO<sub>2</sub> nanoporous modification and platelet-rich plasma treatment on titanium-implant stability in ovariectomized rats

Contact Info

Product

Resources

About