Raman and thermal analysis of indomethacin/PVP solid dispersion enteric microparticles

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

“…For the polymers used, all used polymers matched with published data [15,17,21,[23][24][25][26][27][28][29][30]. While it can be observed for that higher molecular weight chitosan (16 kDa) exhibited more spherical shape.…”

“…FTIR spectra also proved this with the definite disappearance of the only N-H peak of meloxicam (at 3290.3 cm -1 ) for (1:9) ratio, indicating the formation of strong hydrogen bonding while this peak appeared for other ratios. This also was confirmed by SEM analysis, at which the drug was completely incorporated inside chitosan 16 kDa carrier at (1:9) ratio; while free drug appeared around SDs in other ratios [25,27,33].…”

“…PVP made hydrogen bonding with meloxicam mainly through N-H and C=O groups [26]. Also, SEM analysis proved irregular rounded spherical shape [27]. The amorphous form was proved in PXRD [28].…”

“…For FTIR spectra of PVP SDs, there was a disappearance of the three characteristic peaks of meloxicam in the SD of lower meloxicam: PVP ratio. This indicates that PVP and meloxicam have strong hydrogen bonds between them [26,27,31] and precipitation of meloxicam as an amorphous form in PVP prepared SDs. On the other hand, the characteristic peaks of meloxicam appeared in FTIR analysis of PEG SDs confirming its presence as a crystalline form.…”

Estudo da granulação por solidificação de materiais fundidos em leito fluidizado utilizando dispersão sólida de indometacina

“…No caso de soluções sólidas, o tamanho das partículas da droga é reduzido a dimensões moleculares e a velocidade de dissolução é determinada pela velocidade de ser sugerido como uma maneira de estabilizar fases amorfas que poderiam ser protegidas contra recristalização, mantendo as vantagens da amorfização obtidos com ambos os métodos de fusão e solvente para preparar dispersões sólidas (FINI, et al, 2008).…”