Raman detector of carbon isotopes

Popov, E. E.; Polishchuk, Anton; Grigorenko, Konstantin; Chubchenko, Ian; Vitkin, Vladimir

doi:10.1117/12.2556262

Cited by 2 publications

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“…The Raman gas analyzer used is the same as in our recent works [ 25 , 32 ]. In this study, we specified some extra characteristics of the device to estimate its ability to conduct the UBT for the Helicobacter pylori identification.…”

Section: Methodsmentioning

confidence: 99%

Raman Spectroscopy for Urea Breath Test

et al. 2023

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The urea breath test is a non-invasive diagnostic method for Helicobacter pylori infections, which relies on the change in the proportion of 13CO2 in exhaled air. Nondispersive infrared sensors are commonly used for the urea breath test in laboratory equipment, but Raman spectroscopy demonstrated potential for more accurate measurements. The accuracy of the Helicobacter pylori detection via the urea breath test using 13CO2 as a biomarker is affected by measurement errors, including equipment error and δ13C measurement uncertainty. We present a Raman scattering-based gas analyzer capable of δ13C measurements in exhaled air. The technical details of the various measurement conditions have been discussed. Standard gas samples were measured. 12CO2 and 13CO2 calibration coefficients were determined. The Raman spectrum of the exhaled air was measured and the δ13C change (in the process of the urea breath test) was calculated. The total error measured was 6% and does not exceed the limit of 10% that was analytically calculated.

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Section: Methodsmentioning

confidence: 99%

Raman Spectroscopy for Urea Breath Test

et al. 2023

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“…It was possible to shift this range within the interval 530-635 nm. More details can be found in [31].…”

Section: Spectrometermentioning

confidence: 99%

Raman Laser Spectrometer: Application to 12C/13C Isotope Identification in CH4 and CO2 Greenhouse Gases

et al. 2020

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A compact Raman laser gas spectrometer is developed. It comprises a high-power green laser at 532.123 nm as an excitation source and a specially designed gas cell with an internal volume of less than 0.6 cm3 that can withstand gas pressures up to 100 atm. The resolution of the spectrometer is ~1 cm−1. The Raman spectra of chemically pure isotopically enriched carbon dioxide (12CO2, 13CO2) and methane (12CH4, 13CH4) gases are studied. The expected limit of detection (LOD) is less than 100 ppm for the isotopologues of CO2 and less than 25 ppm for those of CH4 (at a gas pressure of 50 atm.), making the developed spectrometer promising for studying the sources of emissions of greenhouse gases by resolving their isotopologue composition. We also show the suitability of the spectrometer for Raman spectroscopy of human exhalation.

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Raman detector of carbon isotopes

Cited by 2 publications

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Raman Spectroscopy for Urea Breath Test

Raman Spectroscopy for Urea Breath Test

Raman Laser Spectrometer: Application to 12C/13C Isotope Identification in CH4 and CO2 Greenhouse Gases

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