Raman fingerprinting of single dielectric nanoparticles in plasmonic nanopores

Kerman, Sarp; Chang, Cheng Jen; Li, Yang; Roy, W. Van; Lagae, Liesbet; Dorpe, Pol Van

doi:10.1039/c5nr05341b

Cited by 36 publications

(31 citation statements)

References 51 publications

(153 reference statements)

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“…[ 29,128–131 ] To meet this demand, nano‐aperture POTs have been combined with Raman spectroscopy. [ 132,133 ] Kerman et al experimentally demonstrated the detection and identification of single dielectric nanoparticles trapped in plasmonic nanopores. Raman tweezers comprised of gold coated plasmonic nanopores with intensely confined local fields are capable of trapping and identifying a 20 nm polystyrene nanoparticles with a single SERS peak at 785 cm −1 ( Figure a).…”

Section: Biosensing With Plasmonic Nanoaperture Tweezersmentioning

confidence: 99%

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Novel Plasmonic Nanocavities for Optical Trapping‐Assisted Biosensing Applications

Koya

Cunha

Guo

et al. 2020

Advanced Optical Materials

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However, due to the intrinsic low optical response of small objects, there has been a clear trade-off between the size of a material and its response to light. [5] Recently, plasmonic nanostructures have emerged as leading platforms to enhance the weak optical signals of low dimensional materials including quantum dots (QDs), [6] small molecules, [7,8] and 2D monolayers. [9] The plasmonic enhancement of linear and nonlinear optical processes capitalizes on the near-and far-field properties of metallic (e.g., gold and silver) nanostructures. [10] One of the defining features of plasmonic nanostructures is their potential to confine light into deep subwavelength volumes, which has opened a new door to trap and manipulate dielectric, metallic, and biological nano-objects. [11] Moreover, metallic nanostructures are characterized by their capability to amplify the intensity of optical fields by orders of magnitude. The enhancement of local field intensity is attributed to the resonance of plasmon polaritons arising from the coupling of external electromagnetic fields to the collective oscillations of the conduction electrons. [12] A small perturbation (or change in the refractive index) of the near field zone of plasmonic nanostructures leads to significant shift in the plasmon polariton resonance wavelength, which has important implications for surface-enhanced sensing and spectroscopic applications. [13,14] Thus, for the ad-hoc enhancement of optical Plasmonic nanocavities have proved to confine electromagnetic fields into deep subwavelength volumes, implying their potentials for enhanced optical trapping and sensing of nanoparticles. In this review, the fundamentals and performances of various plasmonic nanocavity geometries are explored with specific emphasis on trapping and detection of small molecules and single nanoparticles. These applications capitalize on the local field intensity, which in turn depends on the size of plasmonic nanocavities. Indeed, properly designed structures provide significant local field intensity and deep trapping potential, leading to manipulation of nano-objects with low laser power. The relationship between optical trappinginduced resonance shift and potential energy of plasmonic nanocavity can be analytically expressed in terms of the intercavity field intensity. Within this framework, recent experimental works on trapping and sensing of single nanoparticles and small molecules with plasmonic nanotweezers are discussed. Furthermore, significant consideration is given to conjugation of optical tweezers with Raman spectroscopy, with the aim of developing innovative biosensors. These devices, which take the advantages of plasmonic nanocavities, will be capable of trapping and detecting nanoparticles at the single molecule level.

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Section: Biosensing With Plasmonic Nanoaperture Tweezersmentioning

confidence: 99%

Section: Biosensing With Plasmonic Nanoaperture Tweezersmentioning

confidence: 99%

Novel Plasmonic Nanocavities for Optical Trapping‐Assisted Biosensing Applications

Koya

Cunha

Guo

et al. 2020

Advanced Optical Materials

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“…A plasmonic nanoslit is an optically engineered elongated nanopore structure, which has been studied in depth by Chen et al [9,10,14,43,59,[75][76][77][78] As shown in Figure 4e, a nanoslit coated with Au locates at the bottom of an inverted triangular cavity, with periodic shallow grooves on both sides of the cavity to optimize the field enhancement inside the nanoslit. The nanoslit cavity works as a primary antenna to confine SPPs in the cavity, whereas the periodic grooves work as Bragg mirror nanoantennas to reflect the leakage of SPPs back into the nanoslit cavity, or are designed to collect electromagnetic energy from a wide area.…”

Section: Several Kinds Of Plasmonic Nanoporesmentioning

confidence: 99%

“…[9] As for temporal resolution, new functionalities offered by laser or plasmonics make it possible to control the translocation mechanism of molecules. The translocation time of analytes can be tuned from microseconds to seconds, [10][11][12][13][14] which dramatically improves the temporal resolution. In addition, the unique sensitivity and specificity of optical signals will complement the limitations of traditional electrical signals.…”

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confidence: 99%

Electro‐Optical Detection of Single Molecules Based on Solid‐State Nanopores

Tong

et al. 2020

Small Structures

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Solid-state nanopore-based biosensors have received considerable attention in the past two decades and are promising for the next-generation single-molecule detection and sequencing platforms. Typically, the sensor is comprised of a thin inorganic membrane that separates two chambers containing an ion conductive solution. A nanoscale pore is drilled in the membrane as the only channel connecting the two chambers (cis chamber and trans chamber). The charged molecules are driven through the nanopore by an electric field applied across the membrane. At the same time, as the molecules block a fraction of the ionic current that flows through the pore, there will be a set of current pulses. The characteristics of the pulses, such as dwell time (duration of the pulses) and current blockages, give us a wealth of information about the passing analytes. Typically, excluded volumes, charges, capture rates, configurations, dynamics, and possible interactions of the analyte molecules can be concluded from electrical signals. Biological nanopores have been commercially used for DNA sequencing. [1] However, for solid-state nanopores, there are still challenges that need to be addressed for commercial use: specifically, spatial resolution, temporal resolution, and reproducibility. To achieve the identification of nucleotides during a stepwise displacement of DNA through the nanopores, our sensors must have a spatial resolution of 0.34 nm, considering the distance between adjacent base pairs of a double-stranded DNA chain. [2] Such a spatial resolution is a real challenge for nanofabrication of solid-state pores. Temporal resolution depends on the maximum bandwidth of the platforms and translocation speed of the analyte molecules. Limited temporal resolution leads to anomalously low event rates and distorted signals of proteins. [3] Signal reproducibility is another problem for solid-state nanopores compared with their biological counterparts. Biological nanopores, such as α-hemolysin [4] and mycobacterium smegmatis porin A, [5] serve as reliable sensors with excellent signal reproducibility because of the same genetically encoded structure. In comparison, due to the nonuniformity of the fabrication process or other unknown reasons, each solid-state nanopore is slightly different from one to another. In addition, there are other limitations for conventional solid-state nanopore sensors, such as low throughput, background noise, and lack of external handles to manipulate the analytes. Several strategies have been proposed to address these challenges, among which the combination of solid-state nanopores and optical detection has obvious advantages. Introducing a synchronized optical detection would help to improve the spatial resolution of solid-state nanopore platforms. Optical detection, in particular fluorescence [6] and surface-enhanced Raman spectroscopy (SERS), [7,8] has been widely used for

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“…They measured two color codes and presented the ability to read single nucleotide base but with 10% identification error. Others suggested the application of plasmonic structures for unzipping method with a report of simulation results [88,89]. In their report, surface-enhanced Raman signal could separate the information of different nucleotides along DNA strand.…”

Section: Optical Detectionmentioning

confidence: 99%

Speculation of Nano-gap Sensor for DNA sequencing technology: A Review on Synthetic Nanopores

Pungetmongkol

2018

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Nano-gap sensor is the next generation of single molecule analysis that consumes less resources, costs, times and spaces. The ultimate goal of this technology is rendering the ability to determine any living genetic code in several seconds using this portable device. In principle, DNA decryption was determined by tracking electrical signal change when DNA is passed through either natural or synthetic nanometer size gap. This review focuses on the synthetic nanopore, which is more robust, reliable and manageable with ease. Biological nanopore has been researched in parallel; however, the device reproducibility is a controversial issue. The history and development toward the future of this prospect technology will be elaborated attentively. The main limitation of nanopore sensor device is the controlling of DNA translocation dynamic through tiny pore. Many attempts had been tried and the synopsis will be contemplated in the review. Nonetheless, the present results of DNA sequencing have not been satisfied, the development of nanogap sensor is promising for genomic sequencing and molecular biology.

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Raman fingerprinting of single dielectric nanoparticles in plasmonic nanopores

Cited by 36 publications

References 51 publications

Novel Plasmonic Nanocavities for Optical Trapping‐Assisted Biosensing Applications

Novel Plasmonic Nanocavities for Optical Trapping‐Assisted Biosensing Applications

Electro‐Optical Detection of Single Molecules Based on Solid‐State Nanopores

Speculation of Nano-gap Sensor for DNA sequencing technology: A Review on Synthetic Nanopores

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