Raman Spectroscopy for Clinical Oncology

Abstract

Cancer is one of the leading causes of death throughout the world. Advancements in early and improved diagnosis could help prevent a significant number of these deaths. Raman spectroscopy is a vibrational spectroscopic technique which has received considerable attention recently with regards to applications in clinical oncology. Raman spectroscopy has the potential not only to improve diagnosis of cancer but also to advance the treatment of cancer. A number of studies have investigated Raman spectroscopy for its potential to improve diagnosis and treatment of a wide variety of cancers. In this paper the most recent advances in dispersive Raman spectroscopy, which have demonstrated promising leads to real world application for clinical oncology are reviewed. The application of Raman spectroscopy to breast, brain, skin, cervical, gastrointestinal, oral, and lung cancers is reviewed as well as a special focus on the data analysis techniques, which have been employed in the studies.

Multimodal Imaging Spectroscopy of Tissue

“…As described above, near-infrared Raman scattering has been used for the in vivo detection of cancer with high molecular sensitivity (108). However, as Raman scattering is a weak process, the acquisition times of single spectra are in the range of seconds to tens of seconds.…”

Raman spectroscopy in cervical cancers: An update

“…[32,[34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] In 1998, a fiberoptic in vivo Raman study of cervix to delineate precancer lesions from the normal cervix was reported. [39] In this study, in vivo Raman spectra of cervix could be acquired in 90 s. Authors concluded that the increase in the laser power could reduce the integration time to less than 20 s for measuring in vivo Raman spectra of cervix.…”

Raman Microscopy and Associated Techniques for Label-Free Imaging of Cancer Tissue

“…Another statistical method, partial least squares, was used to assign a chemical composition to cancerous tissue in 2005 (19), from a known database of constituents. Because spectroscopy is not the main thrust of this review, the reader is directed toward a review of Raman spectroscopy for cancer diagnosis (20). Most Raman spectroscopy cancer diagnosis is performed on ex vivo tissue but has also been extended to blood serum (21).…”