Ramelteon administration enhances novel object recognition and spatial working memory in mice

Kudara, Mikuru; Kato-Ishikura, Eriko; Ikegaya, Yuji; Matsumoto, Nobuyoshi

doi:10.1016/j.jphs.2023.04.002

Cited by 6 publications

(1 citation statement)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The NOR test was performed in a roofless opaque box (40 cm × 40 cm × 50 cm) equally divided into four quadrants, incorporating the modified method of Kudara et al and Abdalla et al. , It was separated into three phases: habituation, learning training, and testing. Twenty-four hours before learning training, mice were placed in a box without objects to acclimate for 10 min.…”

Section: Materials and Methodsmentioning

confidence: 99%

Dual Action of Reduced Allergenicity and Improved Memory of Instant Soybean Powder Hydrolysates

Ding,

Huang,

Yang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

Section: Materials and Methodsmentioning

confidence: 99%

Dual Action of Reduced Allergenicity and Improved Memory of Instant Soybean Powder Hydrolysates

Ding,

Huang,

Yang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

Folic acid ameliorated the scopolamine-induced memory impairment in mice and the neuroprotective mechanisms

Xu,

Yang,

et al. 2024

Food Bioscience

View full text Add to dashboard Cite

Low Atmospheric Oxygen Attenuates Alpha Oscillations in the Primary Motor Cortex of Awake Rats

Kawamura,

Yoshimoto,

Ikegaya

et al. 2024

Biological & Pharmaceutical Bulletin

Self Cite

View full text Add to dashboard Cite

Oxygen is pivotal for survival of animals. Their cellular activity and cognitive behavior are impaired when atmospheric oxygen is insufficient, called hypoxia. However, concurrent effects of hypoxia on physiological signals are poorly understood. To address this question, we simultaneously recorded local field potentials in the primary motor cortex, primary somatosensory, and anterior cingulate cortex, electrocardiograms, electroolfactograms, and electromyograms of rats under acute hypoxic conditions (i.e., 5.0% O 2 ). Exposure to acute hypoxia significantly attenuated alpha oscillations alone in the primary motor cortex, while we failed to find any effects of acute hypoxia on the oscillatory power in the somatosensory cortex or anterior cingulate cortex. These area-and frequency-specific effects by hypoxia may be accounted for by neural innervation from the brainstem to each cortical area via thalamic relay nuclei. Moreover, we found that heart rate and respiratory rate were increased during acute hypoxia and high heart rate was maintained even after the oxygen level returned to the baseline. Altogether, our study characterizes a systemic effect of atmospheric hypoxia on neural and peripheral signals from physiological viewpoints, leading to bridging a gap between cellular and behavioral levels.

show abstract

Ramelteon administration enhances novel object recognition and spatial working memory in mice

Cited by 6 publications

References 67 publications

Dual Action of Reduced Allergenicity and Improved Memory of Instant Soybean Powder Hydrolysates

Dual Action of Reduced Allergenicity and Improved Memory of Instant Soybean Powder Hydrolysates

Folic acid ameliorated the scopolamine-induced memory impairment in mice and the neuroprotective mechanisms

Low Atmospheric Oxygen Attenuates Alpha Oscillations in the Primary Motor Cortex of Awake Rats

Contact Info

Product

Resources

About