Chemistry is one of the subjects that is quite difficult for students to accept, especially in the introduction to the periodic table of elements, which are not small in number. So there is a need to develop interactive learning media to increase students' interest in learning. This study aims to create an educational game learning media based on the Scramble game that students can use to understand chemistry subjects, especially in introducing the chemical periodic table. The development method used is the Research and Development (R&D) method with a 4D development model (Define, Design, Develop, and Disseminate). In the testing phase, several data were obtained: validation by four experts, including validation by media experts & material experts, and questionnaires by 6 Class X high school students as respondents. Instrumentation validation is calculated using the System Usability Scale (SUS) instrument testing. The calculation of the data for filling out the questionnaire got good results, which means that the learning media of Scramble-based educational games with the introduction of the chemical periodic table material is very appropriate and can be easily understood by students. The calculation results show that making a Scramble-based educational game learning media about the chemical periodic table in Chemistry subjects at SMA Muhammadiyah 1 Surakarta is appropriate and feasible to be used as a learning medium.