Randomised controlled trial of atenolol and pindolol in human pregnancy: effects on fetal haemodynamics.

Abstract

24 Orfan N, Patterson R, Dykewicz MS. Severe angioedema related to ACEinhibitors in patients with a history of idiopathic angioedema. jAMA 1990;264: 1287-9. 25 Sears M. Epidemiological trends in bronchial asthma. In: Kaliner MA, Barnes PJ, Persson CG, eds. Asthma. Its pathology and treatment. Conclusion-The hypotensive effect was similar with both drugs, but only the 13 blocker atenolol had significant effects on fetal haemodynamics, although within normal ranges. The implications of these findings can be only speculative, but negative fetal consequences of 1 adrenoceptor blockade cannot be excluded.

Antihypertensive Medications in Management of Gestational Hypertension-Preeclampsia

“…Thirty-five trials compared 1 antihypertensive with another, applying the same dBP treatment goals to women in both treatment groups. 16,33,[82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97] There was a tendency for ''less tight'' control to be associated with a lower risk of SGA infants (,10th percentile) compared with ''tight'' control (odds ratio [OR] 0.84 [0.65-1.09]). 77,78 The between-trial heterogeneity in outcome, which was not fully explained by antihypertensive type, was explored by metaregression analysis.…”

Randomised controlled trial of methyldopa and isradipine in preeclampsia – effects on uteroplacental and fetal hemodynamics

“…Different effects of antihypertensive drugs can be expected on fetal heart rate and on uteroplacental and fetal hemodynamics. In a randomised control study atenolol (cardioselective ßi-adrenoceptor blocker) and pindolol (nonselective ß-blocker with intrinsic sympathomimetic activity) were compared [14]. FHR decreased and pulsatility index increased in central fetal circulation and volume blood flow decreased with atenolol but not with pindolol [14].…”

HYPERTENSION IN PREGNANCY: Current Concepts of Preeclampsia

“…The presence of these adverse affects may also be confounded by associated maternal disease. Atenolol has adverse effects on uteroplacental and fetal hemodynamics (31), as well as on fetal growth; its use should be avoided in pregnancy (32).…”