Randomised controlled trial showed that neonates received better pain relief from a higher dose of sucrose during venepuncture

Kristoffersen, Laila; Malahleha, Moelo; Duze, Zama; Tegnander, Eva; Kapongo, Ndaye; Støen, Ragnhild; Follestad, Turid; Eik‐Nes, S. H.; Bergseng, Håkon

doi:10.1111/apa.14567

Cited by 9 publications

(9 citation statements)

References 28 publications

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“…1 Newborns commonly experience pain due to a variety of reasons. 2,3 For example, in the first 3e4 days of life, they are subjected to routine invasive procedures such as vitamin K1 injections, 4 checking the anus for patency, 5 hepatitis B vaccination, 6 tuberculosis vaccination, 7 and neonatal screening tests. 8,9 Scientific evidence demonstrates that although newborns lack the ability to express their discomfort and stress in words, they tend to experience the pain at a higher intensity than older children and adults.…”

Section: Introductionmentioning

confidence: 99%

Analgesic effect of non-nutritive sucking in term neonates: A randomized controlled trial

Vu-Ngoc

Uyen

Thinh

et al. 2020

Pediatrics & Neonatology

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Section: Introductionmentioning

confidence: 99%

Analgesic effect of non-nutritive sucking in term neonates: A randomized controlled trial

Vu-Ngoc

Uyen

Thinh

et al. 2020

Pediatrics & Neonatology

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“…The exact amount of each solution was not measured in this study; however, it was likely approximately 0.1 mL based on the report of Mokhnach et al [5]. In many studies supporting the pain-relieving effects of sucrose or human milk, at least 0.2 mL to 2 mL of solution was administered [9,15,19,20]. In addition, a single dose of the solution was administered just once 2 minutes prior to the examination; thus, its effect may not have lasted long enough to span the 2~3 minutes of the examination.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study found that a minimum amount of 0.1 mL of 24% sucrose was effective in reducing pain in preterm and newborn infants undergoing a single heel lance [7,8]. In another recent study, 0.5 mL of 24% sucrose demonstrated better pain-relieving effects than 0.2 mL of the same solution in infants at a gestational age of 28 weeks and weight >1,000 g undergoing venipuncture [9]. However, these studies employed painful, tissue-damaging procedures that are quite short-lasting.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Pain-relieving Effects of Human Milk, Sucrose, and Distilled Water during Examinations for Retinopathy of Prematurity: A Randomized Controlled Trial

Jang¹,

Lee²,

Jo³

et al. 2019

Child Health Nurs Res

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Purpose: This study compared the pain-relieving effects of human milk, sucrose, and distilled water during examinations for retinopathy of prematurity. Methods: Forty-five preterm infants were randomly assigned to receive a pacifier dipped in one of three solutions: human milk (n=14), 24% sucrose (n=15), or distilled water (n=16), 2 minutes before an eye examination. Their pain score, pulse rate, and oxygen saturation were measured at three time points: 5 minutes before the examination, 30 seconds after speculum introduction, and 2 minutes after the examination. Results: The infants' mean gestational age and weight at birth were 33.1±2.1 weeks and 1,842±470 g, respectively. There were no between-group differences in pain relief during the eye examination. The pain score significantly increased both during (p<.001) and after the examinations (p=.003). Oxygen saturation decreased during the examinations (p<.001); however, the infants in the 24% sucrose group showed higher oxygen saturation (p=.047) during the examinations than the infants in the other groups. Conclusion: Sucking on a pacifier dipped in human milk or 24% sucrose did not reduce the pain associated with eye examinations in preterm infants. Pacifiers dipped in sucrose can be used to maintain better oxygen saturation during these examinations.

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“…[26] It was showed that, neonates received better pain relief from 0.5 ml than 0.2 ml sucrose during venipuncture which support our results as we used the same dose. [27] 5. CONCLUSION…”

Section: Discussionmentioning

confidence: 99%

Role of sucrose, pacifier and their combination as pain reliever among preterm neonates during painful procedures

Yousef

Zaki

Ali

2019

JNEP

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Background/Objective: The role of sucrose and/or non-nutritive sucking (NNS) has been evaluated for relieving procedural pain in newborn infants with satisfactory results however there was a controversy regarding the synergestic effect of their combination.}Methods: This quasi-experimental study was conducted in the neonatal intensive care unit in Assiut University Children Hospital including 120 preterm neonates who were divided into 4 groups (20 neonates each). Control group received routine hospital care; sucrose group received oral sucrose solution (OS); pacifier group received pacifier; and last group received oral sucrose solution and pacifier during painful procedures. All were assessed regarding socio-demographic and clinical data in addition to application of Premature Infant Pain Profile (PIPP) scale to assess the levels of pain and mean pain scores pre and post-intervention.Results: The 4 groups were similar regarding soci-demographic and clinical data. The application of the OS and/or pacifier, led to significant improvement of the levels of pain and reduction of the mean score of pain among preterm neonates during painful procedures. In addition, combined pacifier and OS was superior to OS alone and comparable to pacifier alone regarding their effect on the reduction of pain level and mean score of pain.Conclusions: OS and pacifier are effective as pain reliever during painful procedures among preterm neonates. Combined OS and pacifier is superior to OS and pacifier alone.

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Randomised controlled trial showed that neonates received better pain relief from a higher dose of sucrose during venepuncture

Abstract: We showed that neonates received better pain relief from 0.5 mL than 0.2 mL sucrose during venepuncture but not after the needle was removed.

Cited by 9 publications

References 28 publications

Analgesic effect of non-nutritive sucking in term neonates: A randomized controlled trial

Analgesic effect of non-nutritive sucking in term neonates: A randomized controlled trial

Comparison of the Pain-relieving Effects of Human Milk, Sucrose, and Distilled Water during Examinations for Retinopathy of Prematurity: A Randomized Controlled Trial

Role of sucrose, pacifier and their combination as pain reliever among preterm neonates during painful procedures

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