Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration.

Collum, L. M. T.; Benedict-Smith, A.; Hillary, Irene B.

doi:10.1136/bjo.64.10.766

Cited by 97 publications

(29 citation statements)

References 12 publications

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“…Asiklovir dendritik korneal keratitlerde etkin tedavi sağlamaktadır. 10 Kortikosteroidlerin epitelyal herpetik keratitlerde kullanılması kontrendikedir. 11 Ancak diskiform keratitlerin tedavisinde kortikosteroid kombinasyonuna ihtiyaç duyulmaktadır.…”

Section: Discussionunclassified

LASİK Sonrası Geç Dönem Diskiform Endoteliyitis

Oruçoğlu¹,

Ali²

2013

Tjo

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Sum maryClinical and imaging features of the patient with late herpetic keratouveitis after LASIK were investigated. A 25-year-old male patient applied with a chief complaint of blurred vision and photophobia in the left eye. He had a history of herpetic keratitits and elsewhere underwent LASIK procedure in 2005. Oral and topical acyclovir treatments were started a week ago when his complaints started. His corrected distance visual acuity was 0.2 and intraocular pressure was 14 mmHg on the left eye. Slit-lamp revealed deep central disciform edema, keratic precipitates, and 2 positive cells in the anterior chamber. Although the patient had myopic LASIK ablation, the central corneal thickness was 652 microns. Scheimpflug imaging was drawing attention to the thickening of the posterior cornea and the keratic precipitates. Sagital and anterior elevation maps were not affected, however, posterior elevation map showed marked central flattening. Asphericity value Q was within normal limits anteriorly (Q=-0.14) and it was in oblate appearance posteriorly (Q=+5.24). In addition to the antiviral medications, a topical dexamethasone treatment was started. The vision improved to 0.6, and the edema was markedly reduced after 4 days of treatment. Scheimpflug imaging parameters were significantly improved. (Turk J Ophthalmol 2013; 43: 282-5)

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Section: Discussionunclassified

LASİK Sonrası Geç Dönem Diskiform Endoteliyitis

Oruçoğlu¹,

Ali²

2013

Tjo

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“…is sensitive to ACV: experimental (Schaeffer, 1978; in vitro. Pavan-Langston, 1978; animal) and clinical data (Collum, 1980) have shown that ACV has a greater therapeutic effect than I.D.U. even with I.D.U.…”

Section: Discussionmentioning

confidence: 99%

Analysis of HSV isolated from patients with unilateral and bilateral herpetic keratitis

et al. 1985

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Restriction enzyme analysis was utilized to investigate 11 HSV isolates from patients with herpetic keratitis. The electrophoretic profiles of the DNAs indicate that the isolates belong to HSV-1 and are epidemiologically unrelated. Two of the isolates, derived from a patient with simultaneous bilateral herpetic keratitis were further characterized by genetic and phenotypic analyses. These studies showed the following: (i) the two recrudescent lesions were caused by the same HSV-1 isolate; (ii) the isolate yielded two different plaque phenotypes; (iii) these plaques showed different sensitivity to I.D.U.

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“…With the advent of new antivirals, particular Acyclovir [1] and BVDU [2], the outlook for herpetic keratitis has improved significantly. One of the manifestations of herpes simplex in the cornea is stromal, or disciform keratitis.…”

Section: Introductionmentioning

confidence: 99%

“…In a general way this is correct [1], but there are patients in whom Acyclovir is contraindicated. This paper describes the use of Acyclovir in patients with tear film disease and why it is desirable that these patients should be treated with systemic Acyclovir in dendritic corneal ulceration rather than local application of the drug.…”

Section: Introductionmentioning

confidence: 99%

The current management of herpetic eye disease

1992

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Herpes simplex disciform keratitis is a difficult condition. The general feeling is that it is an immune disease, mediated by the virus, possibly located in the endothelial cells. It is frequently combined with inflammation in the trabecular meshwork and with uveitis. There is some controversy in relation to treatment and it has been suggested that anti-virals will control herpetic disciform keratitis, particularly if the patient has never had steroids previously. The authors of this paper have, in the past, published data which showed that Acyclovir, with corticosteroid, was necessary in the management of disciform keratitis. The data suggested that Acyclovir on its own was not effective. It remained to be answered whether Acyclovir on its own would be effective in patients who never had steroids for any reason previously. This paper demonstrates clearly that it is necessary, irrespective of whether patients have had steroids in the past or not, to combine corticosteroids with Acyclovir in the management of herpetic disciform keratitis. Acyclovir, on its own, is shown to be ineffective. It has also been suggested that Acyclovir is non-toxic. In a general way this is true, but the authors suggest that Acyclovir ointment does produce a punctate keratitis in patients with tear film disease, and that oral Acyclovir is preferable in such patients.

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Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration.

Cited by 97 publications

References 12 publications

LASİK Sonrası Geç Dönem Diskiform Endoteliyitis

LASİK Sonrası Geç Dönem Diskiform Endoteliyitis

Analysis of HSV isolated from patients with unilateral and bilateral herpetic keratitis

The current management of herpetic eye disease

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