2022
DOI: 10.1038/s43587-022-00333-6
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Randomization, design and analysis for interdependency in aging research: no person or mouse is an island

Abstract: Investigators traditionally use randomized designs and corresponding analysis procedures to make causal inferences about the effects of interventions, assuming independence between an individual's outcome and treatment assignment and the outcomes of other individuals in the study. Often, such independence may not hold. We provide examples o f i nt erdependency in model organism studies and human trials and group effects in aging research and then discuss methodologic issues and solutions. We group methodologic… Show more

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