Randomized blinded challenge study to assess association between Moraxella bovoculi and Infectious Bovine Keratoconjunctivitis in dairy calves

Gould, Stacie A; Dewell, Reneé D.; Tofflemire, Kyle L.; Whitley, R. David; Millman, Suzanne T.; Opriessnig, Tanja; Rosenbusch, Ricardo F.; Trujillo, Jessie D.; O’Connor, Annette M.

doi:10.1016/j.vetmic.2013.01.038

Cited by 58 publications

(58 citation statements)

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“…bovis as the major causal agent of IBK (Henson and Grumbles, 1960;Lepper and Barton, 1987;O'Connor et al, 2012;Gould et al, 2013). Nevertheless, the disease is clearly multifactorial; outbreaks are influenced by co-infections with other bacteria, such as Mor.…”

Section: Discussionmentioning

confidence: 99%

“…) bovis is considered to be the major causative agent of IBK, since it is the bacterium most frequently isolated from clinical cases (Lepper and Barton, 1987;Alexander, 2010;O'Connor et al, 2012) and is the only pathogen proven to reproduce IBK in challenge models (Henson and Grumbles, 1960;Vogelweid et al, 1986;Gould et al, 2013). However, Mor.…”

Section: Introductionmentioning

confidence: 99%

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Point prevalence of infection with Mycoplasma bovoculi and Moraxella spp. in cattle at different stages of infectious bovine keratoconjunctivitis

Schnee

Heller

Schubert

et al. 2015

The Veterinary Journal

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Point prevalence of infection with Mycoplasma bovoculi and Moraxella spp. in cattle at different stages of infectious bovine keratoconjunctivitis

Schnee

Heller

Schubert

et al. 2015

The Veterinary Journal

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“…9,10 Although a 2007 report of Moraxella bovoculi 11 isolated from eyes of calves affected with IBK has led to increased diagnoses of Mor bovoculi from ocular swabs of cattle with clinical IBK, experimental challenge studies have failed to demonstrate a role for Mor bovoculi in causing corneal ulcers associated with IBK. 12 Nevertheless, the identification of both a cytotoxin in Mor bovoculi 13 and more recently of a putative pilin gene 14 warrant further investigations into the role that Mor bovoculi may play in IBK. It is possible that Mor bovoculi may play a similar role to other pathogens such as Mycoplasma spp and infectious bovine rhinotracheitis (IBR; bovine herpesvirus) that induce ocular pathology and may assist in Mor bovis-associated ocular colonization or spread.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, studies published to date have not proven a direct causal role for Mor bovoculi in IBK. 12 Colonization of the eyes of cattle by Mor bovis 19,20 and Mor bovoculi (JAA; personal observation) can occur in the absence of clinical disease and both organisms can be cultured from the eyes of healthy cattle. Exactly what other intrinsic factors are that might play a role in stimulating otherwise commensal Moraxella spp.…”

Section: Introductionmentioning

confidence: 99%

Infectious Bovine Keratoconjunctivitis (Pinkeye)

Angelos

2015

Veterinary Clinics of North America: Food Animal Practice

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Key Points• Effective treatment of pinkeye requires accurate diagnosis• Antibiotic treatment can the shorten healing time• Multiple routes of antibiotic delivery can be effective• Efforts to develop herd preventive strategies must involve considerations of risk factors Video of classical signs of Infectious bovine keratoconjunctivitis accompanies this article. AbstractAs with many livestock diseases, the most successful efforts to control (Infectious bovine keratoconjunctivitis) IBK include multiple facets of disease control including the host, the environment, herd management, and ongoing surveillance even after the immediate crisis has Discussions of IBK control programs with producers should take into consideration all aspects of the disease including the host immune response and reduction of potential risk factors. Outline Key PointsAbstract Introduction

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“…It has been established that this is the Moraxella spp. most prevalent and the most frequent species isolated from IBK cases [25], although its causal role in IBK is still under debate [1,18,26].…”

Section: Discussionmentioning

confidence: 99%

Virulence genes in Moraxella spp. isolates from infectious bovine keratoconjunctivitis cases

Sosa

Umpiérrez

Acquistapace

et al. 2015

J Infect Dev Ctries

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Introduction: Infectious bovine keratoconjunctivitis (IBK) is an important ocular disease which affects cattle worldwide. To advance towards IBK effective prevention and treatment strategies, it is important to define the distribution and genetic diversity of potential virulence factors present in M. bovis and M. bovoculi. The objective of this work was to identify and to analyze Moraxella spp. potential virulence factor genes in a collection of clinical isolates. Methodology: The presence and diversity of virulence factors in a collection of Moraxella spp. strains isolated since 1983 to 2009 in Uruguay was analyzed by PCR using primers for partial amplification of tolC, omp79, plb, fur and mbxA. The selection criterion of these genes was based on the fact that they encode virulence factors which could be present and conserved within strains, an important issue for the development of vaccines. Results: Differences in PCR amplification were observed within tolC (84%), omp79 (80%), plb (76%) and fur (44%) in M. bovis strains, whereas mbxA was amplified in all M. bovis and M. bovoculi strains. Regarding genetic diversity, the tolC nucleotide sequences were the less diverse within all M. bovis and mbxA were the less diverse within all M. bovis and M. bovoculi strains. Conclusions: PCR amplifications suggest the occurrence of differences between both Moraxella species, related to evaluated genes within Moraxella spp. strains and suggests that both species may have different pathogenic attributes. MbxA and the outer membrane protein TolC might be considered for future studies to develop new vaccines against IBK.

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Randomized blinded challenge study to assess association between Moraxella bovoculi and Infectious Bovine Keratoconjunctivitis in dairy calves

Cited by 58 publications

References 10 publications

Point prevalence of infection with Mycoplasma bovoculi and Moraxella spp. in cattle at different stages of infectious bovine keratoconjunctivitis

Point prevalence of infection with Mycoplasma bovoculi and Moraxella spp. in cattle at different stages of infectious bovine keratoconjunctivitis

Infectious Bovine Keratoconjunctivitis (Pinkeye)

Virulence genes in Moraxella spp. isolates from infectious bovine keratoconjunctivitis cases

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