Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis

Rodríguez-Agurto, Alejandro; Bravo, Manuel; Magán‐Fernández, Antonio; López-Toruño, Ana; Muñoz, Ricardo; Ferrer, Joaquín; Mesa, Francisco

doi:10.1038/s41598-023-33521-4

Cited by 4 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Galán et al modeled an integrated biorefinery for the production of xylitol and sorbitol from lignocellulosic biomass [87]. Xylitol is also used in toothpaste formulations to combat gingivitis and other serious oral problems [88].…”

Section: Xylitol and Sorbitolmentioning

confidence: 99%

Unlocking the Potential of Fermentation in Cosmetics: A Review

Pérez-Rivero

López‐Gómez

2023

Fermentation

View full text Add to dashboard Cite

The cosmetic segment is a rapidly growing industry that has been challenged in recent years due to the origin and impact of its ingredients and manufacturing techniques. With a focus on reducing carbon dioxide emissions and improving the degradability of products, many conventional ingredients are being dismissed to meet more exigent regulations and consumer ethical demands. Biotechnology, and fermentation as the core technology, is a solution to support and drive more sustainable growth for the cosmetic industry. This review presents the latest research and development in fermentation applied to cosmetics and showcases multiple examples throughout all classes of ingredients: from functional compounds, such as oil and surfactants, to multi-faceted molecules with a wide spectrum of formulations and skin benefits derived from their emulsifying, antimicrobial or antioxidant properties. The bottlenecks associated with the commercialization of such ingredients, together with successful examples, are also discussed. The shift towards a bio-based beauty industry requires a combination of technical, regulatory and marketing efforts. Fermentation strategies to better utilize low-cost substrates and optimize microorganisms and processes will reduce overall costs, reducing the price gap with traditional methods of production. The testing, standardization and regulation of these new ingredients need to catch up with the fast research happening in the field. Finally, consumer communication is key to achieve a successful introduction of biotech ingredients in the market.

show abstract

Section: Xylitol and Sorbitolmentioning

confidence: 99%

Unlocking the Potential of Fermentation in Cosmetics: A Review

Pérez-Rivero

López‐Gómez

2023

Fermentation

View full text Add to dashboard Cite

show abstract

“…In this respect, a fresh-from-the-press controlled, doubleblind, and multicenter randomized clinical trial, declared at ClinicalTrials.gov (https: //clinicaltrials.gov/ct2/show/NCT05463484 (accessed on 19 July 2022)) as part of the Stop Dysbiosis Project, has shown statistically significant superior clinical outcomes in oral clinical parameters in patients with oral dysbiosis with the use of a microbiome-boosting toothpaste containing extra virgin olive oil (EVOO), xylitol, and betaine. While the control and placebo groups resulted in significant decreases in pH levels, the tested group kept pH levels at the physiologic value, contributing to oral eubiosis [87]. A low pH has been documented at dysbiotic sites with inflammation or cell destruction [88].…”

Section: Elad Et Al [84] 65%mentioning

confidence: 99%

Oral Mucosa in the Cancer Patient; Putting the Pieces Together. A Narrative Review and New Perspectives.

Reuss,

Alonso-Gamo,

Garcia-Aranda

et al. 2023

Preprint

View full text Add to dashboard Cite

Oral mucosa is a key player in the cancer patient and during cancer treatment. The increasing prevalence of cancer and cancer therapy associated side effects are behind the major role that oral mucosa plays in the oncological patient. Oral mucositis is a debilitating severe complication caused by early toxicity of chemo and/or radiotherapy that can restrict treatment outcome possibilities, even challenging patient’s survival. It has been referred to as the most feared cancer treatment complication. Predictive variables as to who and to what extent will be affected are still unclear. Additionally, oral mucositis is one of the sources of the increasing economic burden of cancer, not only for patients and their families but also for institutions and governments. All efforts should be implemented in the search for new approaches to minimize the apparently ineluctable outburst of oral mucositis along the cancer treatment. New perspectives derived from different approaches in explaining the interrelation between oral mucositis and oral microbiome or the similarities with genitourinary mucosa may help elucidate the biomolecular pathways and mechanisms behind oral mucosa cancer-therapy related toxicity and what is more important its management in order to minimize treatment side effects and to provide enhanced cancer support.

show abstract

“…In this respect, a fresh-from-the-press controlled, double-blind, and multicenter randomized clinical trial, declared at ClinicalTrials.gov ( (accessed on 19 July 2022)) as part of the Stop Dysbiosis Project, has shown statistically significant superior clinical outcomes in oral clinical parameters in patients with oral dysbiosis with the use of a microbiome-boosting toothpaste containing extra virgin olive oil (EVOO), xylitol, and betaine. While the control and placebo groups resulted in significant decreases in pH levels, the tested group kept pH levels at the physiologic value, contributing to oral eubiosis [ 87 ]. A low pH has been documented at dysbiotic sites with inflammation or cell destruction [ 88 ].…”

Section: Measures To Improve Oral Mucosal Resilience In Cancer Treatm...mentioning

confidence: 99%

Oral Mucosa in Cancer Patients—Putting the Pieces Together: A Narrative Review and New Perspectives

Reuss,

Alonso-Gamo,

Garcia-Aranda

et al. 2023

Cancers

View full text Add to dashboard Cite

The oral mucosa is a key player in cancer patients and during cancer treatment. The increasing prevalence of cancer and cancer-therapy-associated side effects are behind the major role that oral mucosa plays in oncological patients. Oral mucositis is a debilitating severe complication caused by the early toxicity of chemo and/or radiotherapy that can restrict treatment outcome possibilities, even challenging a patient’s survival. It has been referred to as the most feared cancer treatment complication. Predictive variables as to who will be affected, and to what extent, are still unclear. Additionally, oral mucositis is one of the sources of the increasing economic burden of cancer, not only for patients and their families but also for institutions and governments. All efforts should be implemented in the search for new approaches to minimize the apparently ineluctable outburst of oral mucositis during cancer treatment. New perspectives derived from different approaches to explaining the interrelation between oral mucositis and the oral microbiome or the similarities with genitourinary mucosa may help elucidate the biomolecular pathways and mechanisms behind oral mucosa cancer-therapy-related toxicity, and what is more important is its management in order to minimize treatment side effects and provide enhanced cancer support.

show abstract

Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis

Cited by 4 publications

References 38 publications

Unlocking the Potential of Fermentation in Cosmetics: A Review

Unlocking the Potential of Fermentation in Cosmetics: A Review

Oral Mucosa in the Cancer Patient; Putting the Pieces Together. A Narrative Review and New Perspectives.

Oral Mucosa in Cancer Patients—Putting the Pieces Together: A Narrative Review and New Perspectives

Contact Info

Product

Resources

About