Randomized control trial of quinine and artesunate in complicated malaria

Abstract

Artesunate is a much better drug than quinine in complicated malaria in terms of rapid coma resolution, fever clearance, parasite clearance and better tolerability.

Malaria Chemotherapeutics Part I: History of Antimalarial Drug Development, Currently Used Therapeutics, and Drugs in Clinical Development

“…A study on 80 children with complicated malaria conducted in India showed the superiority of artesunate (42) over quinine (1). [183] In a recent study conducted in various regions of Asia, intravenous artesunate was significantly superior to the standard i.v. regime with quinine in the treatment of adult severe malaria.…”

Artemisinin derivatives Versus quinine for severe malaria in children: A systematic review and meta-analysis

“…Seven trials reported fever clearance time, though three (8,11,12) presented data in a format that precluded meta-analysis; the remainder (9,(15)(16)(17) showed comparable results between all three artemisinin derivatives and quinine. All trials reported coma recovery time, though three (8,11,12) could not be included in meta-analysis.…”

“…The trials examined mortality, clinical outcomes (fever clearance time, coma recovery time, neurological sequelae), parasite clearance and some side effects. (Table II) was low for three trials (11,12,14), moderate for another three (8,10,17) and high for four trials (9,13,15,16). Only one trial(11) provided a sample size calculation.…”

“…Table I summarizes the trial characteristics. Two trials compared quinine with artesunate (8,9), six with artemether(10-15), and two with arteether (16,17). Four trials recruited only participants with cerebral malaria (10,11,13,14).…”

A Convenient Synthesis of Some Coumarin Derivatives Using SnCl2 · 2H2O as Catalyst

“…Coumarins constitute an important class of compound due to their presence as an important constituent of natural products [1] as well as their variety of medicinal applications such as anti-inflammatory [2], anti-convulsant [3], anti-viral [4], anticoagulent [5], antioxidant [6], antibacterial [7], antifungal [8], anti-HIV [9], anti-carcinogenic material [10] and as antihistamine [11]. Besides the wide spectrum biological applications of coumarin and its derivatives the chemical literature also embodies their some applications from the material view point such as cosmetics [12], optical brightening agents [13], and laser dyes [14].…”