Randomized controlled clinical trial on bleaching sensitivity and whitening efficacy of hydrogen peroxide versus combinations of hydrogen peroxide and ozone

Abstract

The clinical efficacy regarding bleaching sensitivity and tooth shade lightening using a standard hydrogen peroxide (H2O2) bleaching gel was compared with the additional use of ozone either before or after application of H2O2. Using computer-generated tables, 45 participants were randomly allocated into three groups (n = 15 each) in this investigator-driven, single-centre trial. In Group 1, upper anterior teeth were bleached using ozone (produced via a healOzone X4 device) for 60 seconds, then 38% H2O2 for 20 minutes; in Group 2, 38% H2O2 application (20 min) was followed by ozone (60 s); air produced by the healOzone machine (60 s) followed by 38% H2O2 (20 min) was used in Group 3 (control). Bleaching sensitivity was evaluated via visual analogue scales, and a treatment-blinded reader objectively recorded tooth shades using a colorimeter before and 24 hours after bleaching (at α = 0.05). The H2O2/ozone combination did not result in pain sensations, while both ozone/H2O2 and H2O2 alone increased bleaching sensitivity (p < 0.001). Teeth achieved lighter shades (higher L*/lower b* values) after bleaching in all groups (p < 0.001), while Ozone boosted lighter tooth shades, irrespective of its use before or after H2O2 (p < 0.05). Due to the complimentary effects, applying ozone after H2O2 seems preferable for bleaching.

Tooth whitening: From the established treatments to novel approaches to prevent side effects

“…74 It has shown that the whitening efficacy of hydrogen peroxide is enhanced with application of ozone, without an increase of tooth hypersensitivity. 82 The same happens when nitrogen-doped titanium dioxide is combined with low concentrations of oxidant agents. 83 Other compounds like strontium chloride and potassium nitrate combined with fluoride do not interfere with the whitening effect, but they improve the process reducing the morphological changes in the enamel.…”

“…Besides, these kinds of dentifrices have potential activity against Streptococcus mutants . It has shown that the whitening efficacy of hydrogen peroxide is enhanced with application of ozone, without an increase of tooth hypersensitivity . The same happens when nitrogen‐doped titanium dioxide is combined with low concentrations of oxidant agents .…”

Particular device producing ozonated water to treat dentinal sensitivity: a pilot study

“…Antimicrobial activity was tested also tested on less studied bacterial species [21,22,23]. Another interesting application of ozonated water is the use at a cosmetic level for dental bleaching.…”

Utilização Da Ozonioterapia Em Odontologia/ Use of Ozoniotherapy in Dentistry

“…Concentração não descrita. Aplicação de ozônio para cada dente foi realizado duas vezes, nos dias 3 e 8, após o tratamento periodontal Al-Omiri et al, Jordânia (2018) 33 Avaliar a eficácia clínica em relação à sensibilidade ao clareamento usando um gel clareador padrão de peróxido de hidrogênio (H2O2) comparada com o uso adicional de ozônio antes ou após a aplicação desse peróxido.…”