Randomized controlled clinical trials on agents used for chemical plaque control

Paraskevas, S.P.

doi:10.1111/j.1601-5037.2005.00145.x

Cited by 71 publications

(54 citation statements)

References 80 publications

(126 reference statements)

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“…However, it has adverse effects when used for a prolonged period of time, such as staining the teeth, changes in taste and increase in the formation of supragingival biofi lm. Th erefore, its use is limited to situations in which mechanical oral hygiene is compromised 5 .…”

mentioning

confidence: 99%

Herbal mouthwash based on Libidibia ferrea: microbiological control, sensory characteristics, sedimentation, pH and density

Venâncio

Rodrigues

Souza

et al. 2015

Rev. odontol. UNESP

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Introduction Phytotherapy is the study of herbal medicines and their applicability to cure diseases in general, being a therapeutic method which can be used for the prevention and treatment of mouth diseases. Among the herbal studied, the Libidibia ferrea, known as jucá or ironwood, is widely used in folk medicine by presenting anti-inflammatory, analgesic, antimicrobial and antipyretic therapeutic properties. Objective To evaluate in vitro pharmacological stability of the Libidibia ferrea extract’s mouthwash (INPA - 228 022). Material and method It was held the mouthwash microbiological control by determining the total number of microorganisms and Salmonella sp, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus; stability characteristics (color, odor, brightness and consistency), sedimentation test (centrifuge), the pH measurement (pH meter) and density evaluation (pycnometer) were analyzed. Result The mouthwash showed to be absent from microorganisms and no changes were observed in the organoleptics and sedimentation characteristics. The average pH values were 6.21, 6.15 and 5.85 at 0, 30 and 60 days, respectively, and 1.029, 1.033 and 1.035 g/ mL density values, respectively, without interfering with the final characteristic of the formulation. Conclusion The mouthwash presented pharmacological stability and quality conditions.

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confidence: 99%

Herbal mouthwash based on Libidibia ferrea: microbiological control, sensory characteristics, sedimentation, pH and density

Venâncio

Rodrigues

Souza

et al. 2015

Rev. odontol. UNESP

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“…A Propomax® testada neste estudo utiliza própolis verde derivado da Baccharis dracunculifolia (Park et al, 2002), uma planta nativa do sudeste e sul do Brasil, também conhecida como própolis verde e contém como principais componentes bioativos a artepilina C e ácidos cumarínicos que são respectivamente relacionados às suas propriedades antibacteriana e antiinflamatória (Moura et al, 2009). O efeito antiinflamatório é obtido com modulação das citocinas e enzimas, supressão da produção de prostaglandinas, leucotrienos, histamina e TGF-β1 (Moura et al;2009;Galvão et al, 2007).…”

Section: Discussionunclassified

“…Desse modo, o uso de antimicrobianos locais e/ou sistêmicos como adjuntos para eliminar periodontopatógenos pode ser indicado como preventivo ou auxiliar no tratamento da DP (Haffajee et al, 2003b) Clorexidina (Paraskevas, 2005), Cloreto de cetilpiridínio (Alves et al, 2012), Triclosan (Davies et al, 2004) e outras substâncias químicas são utilizadas como auxiliares na inibição da formação de placa bacteriana com o intuito de impedir o desenvolvimento da DP. O digluconato de clorexidina a 0,2% ou 0,12% é um agente antimicrobiano de amplo espectro, e tem tido destaque por seu baixo custo e alta substantividade (Calderini et al, 2013), principalmente quando usado em uma superfície dentária que foi previamente limpa, dessa forma atuando como preventivo na progressão da DP (Brecx, 1997).…”

Section: Introductionunclassified

Resultados da aplicação tópica do extrato de própolis na redução da progressão da doença periodontal

Ribeiro

Gualberto

Silva

et al. 2015

Rev. bras. plantas med.

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RESUMO:Agentes químicos têm sido usados para auxiliar na inibição da formação do biofilme e impedir desenvolvimento da doença periodontal (DP). O objetivo deste estudo foi avaliar radiograficamente a ação do extrato de própolis na progressão da DP induzida em ratos. Foram utilizados 48 ratos Wistar, divididos em 4 grupos (n=12): Controle, Pincel, Própolis e Clorexidina. Os grupos foram subdivididos para análise aos 7 e 21 dias. A progressão da DP foi avaliada radiograficamente pela distância entre a junção cemento-esmalte e a crista óssea alveolar na face mesial do 1º molar inferior. A perda óssea foi significativamente menor nos animais do grupo própolis em ambos os períodos (p ≤ 0,01). Concluiu-se por análise radiográfica que a aplicação tópica do extrato de própolis interfere reduzindo a progressão da doença periodontal induzida por ligadura em ratos, demonstrando a importância desse composto como substância auxiliar no tratamento periodontal.Palavras-Chave: Periodontia, Própolis, Radiografia.ABSTRACT: Results of topical application of propolis extracts in reducing progression of periodontal disease. Chemical agents have been used to assist on inhibiting biofilm formation and on preventing the development of periodontal disease (PD). The aim of this study was to radiographically evaluate the action of propolis extract on the progression of PD induced in rats. 48 Wistar rats were divided into 4 groups (n = 12): Control, Brush, Propolis and Chlorhexidine. The groups were subdivided for analysis at 7 and 21 days. The progression of the periodontal disease was radiographically assessed by the distance between the cement-enamel junction and the alveolar bone crest mesial of the 1st molar. Bone loss was significantly lower in the Propolis group in both periods (p ≤ 0.01). By radiographic analysis, it is concluded that the topical application of propolis extract interferes by reducing the progression of ligature-induced periodontal disease in rats, demonstrating the importance of this compound as an auxiliary substance in periodontal treatment.

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“…[13] The four day plaque re-growth crossover study design was chosen for the present endeavour as it has been employed in numerous investigations and can be described as an established method for assessing the plaque inhibitory activity of formulation per se and determines the relative efficacy of different formulations. [10,[14][15][16][17] .…”

Section: Discussionmentioning

confidence: 99%

The Plaque Inhibitory Effect of Aloe Vera Mouthrinse in A Four Day De Novo Plaque Formation Model- A Randomized, Double Blind Crossover Study

Daing¹,

Sawai²,

Bhardwaj³

et al. 2016

IOSR

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Randomized controlled clinical trials on agents used for chemical plaque control

Cited by 71 publications

References 80 publications

Herbal mouthwash based on Libidibia ferrea: microbiological control, sensory characteristics, sedimentation, pH and density

Herbal mouthwash based on Libidibia ferrea: microbiological control, sensory characteristics, sedimentation, pH and density

Resultados da aplicação tópica do extrato de própolis na redução da progressão da doença periodontal

The Plaque Inhibitory Effect of Aloe Vera Mouthrinse in A Four Day De Novo Plaque Formation Model- A Randomized, Double Blind Crossover Study

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