Randomized controlled trial comparing laparoscopic ovarian diathermy with clomiphene citrate as a first-line method of ovulation induction in women with polycystic ovary syndrome

Amer, Saad; Li, Tin‐Chiu; Metwally, Mostafa; Emarh, Mohamed; Ledger, William

doi:10.1093/humrep/den325

Cited by 67 publications

(37 citation statements)

References 30 publications

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“…15 Miscarriage rate following LOD in our series was similar to the previously reported figures. 25,26 Of the five multiple pregnancies reported in our cohort none occurred after spontaneous conception and their frequency was similar to what was previously described (0% -10%). 15 Laparoscopic ovarian diathermy is not a curative treatment for PCOS, but is associated with long-term beneficial effects.…”

Section: Discussionsupporting

confidence: 90%

Short and Long-Term Efficacy of Laparoscopic Ovarian Diathermy in Women with Polycystic Ovary Syndrome

Luz¹,

Barros²,

Aguiar³

et al. 2016

Acta Med Port

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Introduction:Polycystic ovary syndrome is the most frequent cause of anovulatory infertility and management involves a multistep approach. Laparoscopic ovarian diathermy is accepted as a second-line treatment of patients who failed to respond to clomiphene citrate. The aims of this study were to determine the efficacy of this technique at short and long-term and to perform an analysis of predictive factors of spontaneous pregnancy. Material and Methods:This retrospective study involved 76 women who underwent laparoscopic ovarian diathermy between 2004 and 2013 in a university hospital. Main outcomes were cycle regularity and pregnancy. Short-term outcomes recorded during followup in our centre were reviewed and long-term outcomes were evaluated by a telephone interview to all women whose surgery was undertaken more than three years ago. Clinical and biochemical data were analysed as predictive factors of spontaneous conception in patients without other infertility factors.Results: Menstrual cycle regularity was initially achieved in 53 (70%) women and in the long-term follow-up subgroup, 52% (12/23) had regular periods. In general, 53 (70%) women conceived and 77 pregnancies were achieved, 60% of which were spontaneous. The only prognostic factor found to be significantly associated with spontaneous conception was a shorter duration of infertility (< 3 years) (p < 0.05). Discussion: Laparoscopic ovarian diathermy showed pregnancy rates comparable to other ovulation induction treatments with the advantage of having a long lasting beneficial effect in menstrual regularity and fertility. Conclusion: Laparoscopic ovarian diathermy is a safe and effective treatment option for anovulatory infertility in women with polycystic ovary syndrome.

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Section: Discussionsupporting

confidence: 90%

Short and Long-Term Efficacy of Laparoscopic Ovarian Diathermy in Women with Polycystic Ovary Syndrome

Luz¹,

Barros²,

Aguiar³

et al. 2016

Acta Med Port

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“…In IVM, immature oocytes are collected without exposing them to gonadotropin stimulation (9). Compared with IVF, IVM is simpler, less costly, and more importantly avoids the risk of OHSS.…”

mentioning

confidence: 99%

Effects of ovarian puncture for in vitro maturation on subsequent in vitro fertilization cycle in women with polycystic ovaries

Agdi

Zarei

Al-Sannan

et al. 2010

Fertility and Sterility

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“…Laparoscopic ovarian drilling improves ovulation rates likely through destruction of theca cells in the ovary that produce androgens resulting in increased FSH levels and reduced LH levels conducive to normal follicular development. As a first line treatment, randomised trials have shown similar results for ovulation, conception and live birth rates when compared with up to 6 cycles of clomiphene [42] and has a likely ongoing success rate without the risk of multiple pregnancy from clomiphene.…”

Section: Laparoscopic Ovarian Drillingmentioning

confidence: 93%

Fertility Treatment for Women with PCOS

Langdon¹,

Pontré²,

Hart³

2017

Testes and Ovaries - Functional and Clinical Differences and Similarities

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Polycystic ovarian syndrome is the commonest cause of anovulatory infertility. This chapter will explore fertility treatment options for this condition including the risks, benefits and success rates for different treatment methods. The importance of close patient monitoring with hormone levels and pelvic ultrasounds to ensure mono-ovulation and to avoid ovarian hyperstimulation syndrome will be highlighted.

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Randomized controlled trial comparing laparoscopic ovarian diathermy with clomiphene citrate as a first-line method of ovulation induction in women with polycystic ovary syndrome

Abstract: LOD is not superior to CC as a first-line method of OI in women with PCOS. The trial is registered with ClinicalTrials.gov with an identifier number NCT00220545.

Cited by 67 publications

References 30 publications

Short and Long-Term Efficacy of Laparoscopic Ovarian Diathermy in Women with Polycystic Ovary Syndrome

Short and Long-Term Efficacy of Laparoscopic Ovarian Diathermy in Women with Polycystic Ovary Syndrome

Effects of ovarian puncture for in vitro maturation on subsequent in vitro fertilization cycle in women with polycystic ovaries

Fertility Treatment for Women with PCOS

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