Randomized controlled trial of Inquiry-Based Stress Reduction (IBSR) technique for<i>BRCA1</i>/<i>2</i>mutation carriers

Landau, Carla; Lev-Ari, Shahar; Cohen‐Mansfield, Jiska; Tillinger, Efrat; Geva, Ravit; Tarrasch, Ricardo; Mitnik, Inbal; Friedman, Eitan

doi:10.1002/pon.3703

Cited by 12 publications

(29 citation statements)

References 9 publications

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“…In the intervention group, there was an improvement in sleep quality (average 7.48 ± 3.98 to 5.42 ± 3.64) and cancerrelated worries (average 2.08 ± 0.62 to 1.96 ± 0.81), however, these differences were not significant. Clinical distress levels were similar for all the participants (Landau et al, 2014).…”

Section: Clinical Evidence Of Ibsrmentioning

confidence: 77%

Inquiry-Based Stress Reduction: Another approach for questioning stressful thoughts and improving psychological well-being

Rhijn¹,

Mitnik

Lev-Ari

2015

MRAJ

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Section: Clinical Evidence Of Ibsrmentioning

confidence: 77%

Inquiry-Based Stress Reduction: Another approach for questioning stressful thoughts and improving psychological well-being

Rhijn¹,

Mitnik

Lev-Ari

2015

MRAJ

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“…The RNA export factor ALY is elevated in oral squamous cell carcinoma patient specimens [112]. Recent studies indicate that mutation of NXF1 in mice can lead to disruptions in hematopoiesis in a lineage-specific manner [113], and NXF1 has been found to be mutated in chronic lymphocytic leukemia (CLL) patients [114][115][116]. The germinal center associated protein (GANP), a component of the TREX2 complex, is highly elevated in several types of lymphomas [117].…”

Section: Changes In the Npc Associated With Mrna Export And Cancermentioning

confidence: 99%

The Nuclear Pore Complex and mRNA Export in Cancer

Borden

2020

Cancers

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Export of mRNAs from the nucleus to the cytoplasm is a key regulatory step in the expression of proteins. mRNAs are transported through the nuclear pore complex (NPC). Export of mRNAs responds to a variety of cellular stimuli and stresses. Revelations of the specific effects elicited by NPC components and associated co-factors provides a molecular basis for the export of selected RNAs, independent of bulk mRNA export. Aberrant RNA export has been observed in primary human cancer specimens. These cargo RNAs encode factors involved in nearly all facets of malignancy. Indeed, the NPC components involved in RNA export as well as the RNA export machinery can be found to be dysregulated, mutated, or impacted by chromosomal translocations in cancer. The basic mechanisms associated with RNA export with relation to export machinery and relevant NPC components are described. Therapeutic strategies targeting this machinery in clinical trials is also discussed. These findings firmly position RNA export as a targetable feature of cancer along with transcription and translation.

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“…Furthermore, IBSR: The Work of Byron Katie has also recently been shown to be effective in improving psychological symptoms and quality of life in a pilot clinical study by Smernoff et al . in a non-clinical setting [61], and it has also been used in a randomised controlled trial to examine the effect on psychological wellbeing among oncologically-healthy carriers of the BRCA1/2 mutation [62]. Similar interventions can potentially be a cost-effective means to control stress and improve quality of life among the general population [63] (also reviewed in [64]), and have also been shown to create reductions in psychological distress, sleep disturbance and fatigue, as well as increases in positive psychological outcomes, in cancer patients–reviewed in Rouleau et al .…”

Section: Introductionmentioning

confidence: 99%

‘We are the change’ - An innovative community-based response to address self-stigma: A pilot study focusing on people living with HIV in Zimbabwe

MacDonald

Conroy

Chiroro³

et al. 2019

PLoS ONE

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Introduction Self-stigma–negative self-judgements resulting in shame, worthlessness and self-blame–may play a crucial role in emotional reactions and cause emotional distress among many people living with HIV and other chronic illnesses. Furthermore, self-stigma negatively impacts on self-agency, quality of life, adherence to treatment, and access to services. High levels of self-stigma have been reported across many countries, however few programmes or interventions exist to specifically tackle this phenomenon. This paper reports the findings of a pilot study carried out in Zimbabwe using a programme incorporating “Inquiry-Based Stress Reduction (IBSR): The Work of Byron Katie”–a guided form of self-inquiry which helps users to overcome negative thoughts and beliefs. Objectives The primary objective of this uncontrolled pilot study was to examine the potential role of the IBSR intervention in helping people living with HIV to overcome self-stigma and associated states. Methods 23 people living with HIV (17 Female, 6 male, average age 41 years) were recruited from a local HIV support network, via open call for volunteers. All participants received the intervention, consisting of a 12-week facilitated programme using techniques derived from IBSR: The Work of Byron Katie. Qualitative and quantitative data were collected and analysed pre- and post-programme. Results After taking part in the intervention, participants reported significant improvements in factors including self-stigma (1-month follow-up vs baseline Z = 2.1, p = 0.039; 3-month follow-up vs baseline Z = 3.0, p = 0.003, n = 23, Wilcoxon Matched Pairs Signed Rank Test) and depression (1mo vs baseline Z = 3.7, p = <0.001; 3mo vs baseline Z = 3.3, p = 0.001). Qualitatively, participants reported improvements including lessened fears around disclosure of their HIV status, reduced feelings of life limitations due to HIV, and greater positive mentality. Improvements persisted at three-month follow-up. Conclusion With further development and larger comparative studies to confirm effects, the IBSR programme could become a novel tool to enable people living with HIV to support themselves in overcoming self-stigma.

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Randomized controlled trial of Inquiry-Based Stress Reduction (IBSR) technique forBRCA1/2mutation carriers

Cited by 12 publications

References 9 publications

Inquiry-Based Stress Reduction: Another approach for questioning stressful thoughts and improving psychological well-being

Inquiry-Based Stress Reduction: Another approach for questioning stressful thoughts and improving psychological well-being

The Nuclear Pore Complex and mRNA Export in Cancer

‘We are the change’ - An innovative community-based response to address self-stigma: A pilot study focusing on people living with HIV in Zimbabwe

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