Randomized, controlled trial of low molecular weight heparin vs. no deep vein thrombosis prophylaxis for major colon and rectal surgery in Asian patients

Ho, Yik‐Hong; Seow‐Choen, Francis; Leong, A. F. P. K.; Eu, Kong‐Weng; Nyam, D. C. N. K.; Teoh, M. K.

doi:10.1007/bf02237127

Cited by 70 publications

(82 citation statements)

References 22 publications

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“…These results are comparable to those of a prospective cohort study evaluating the safety of FPX for the prevention of VTE in Japanese patients undergoing CRC surgery, which reported incidences of 0.81 and 9.5%, respectively [10]. In several studies evaluating the safety of LMWH for the prevention of VTE after CRC surgery, the incidence of major bleeding and minor bleeding was reported to be 0.89-2.7% and 4.5-8.0%, respectively [13,14,15], similar to our results. These results suggest that FPX is comparable to LMWH in terms of prevention of symptomatic VTE and postoperative bleeding in patients undergoing CRC surgery.…”

Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Fondaparinux for Prophylaxis of Venous Thromboembolism after Colorectal Cancer Resection: A Propensity Score Matched Analysis

et al. 2015

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Background/Aims: The aim of this study was to examine the safety and efficacy of fondaparinux (FPX) for venous thromboembolism (VTE) prophylaxis after colorectal cancer surgery. Methods: Records of 953 patients with colorectal cancer who underwent resection between 2006 and 2013 were reviewed. Patients were divided into two groups: the FPX group (n = 362), treated with subcutaneous FPX plus intermittent pneumatic compression (IPC) and the IPC group (n = 591), treated with IPC alone. The incidence of symptomatic VTE, major bleeding, minor bleeding, and other postoperative complications were compared using propensity score matching. Results: Symptomatic VTE occurred only in one patient (0.2%) in the IPC group. In the FPX group, the incidence of major and minor bleeding was 0.55% (2 of 362) and 9.4% (34 of 362), respectively. After propensity score matching, there were no differences between the two groups in the incidence of symptomatic VTE, major bleeding, and other common postoperative complications. Only the incidence of minor bleeding was significantly higher in the FPX group compared to the IPC group. Conclusion: FPX is potentially an effective form of VTE prophylaxis; it is safe in terms of both postoperative bleeding and other common complications after colorectal cancer surgery.

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Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Fondaparinux for Prophylaxis of Venous Thromboembolism after Colorectal Cancer Resection: A Propensity Score Matched Analysis

et al. 2015

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“…To our knowledge, only five small open studies have evaluated a prophylactic method in Asian patients. 18,[31][32][33][34] These studies were small in size and the beneficial effect of treatment was in general not statistically significant, but all showed that prophylaxis could reduce the rate of venous thromboembolism to some extent. Although these data should be confirmed in larger well-conducted multicenter studies, we believe that there is no reason why the benefit of thromboprophylaxis, well documented in the West, 4 should not also be achieved in Asian patients.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of post-operative venous thromboembolism in Asian patients. Results of the SMART venography study

Leizorovicz¹

2007

Haematologica

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“…The autopsy prevalence of PE was lower in Japanese (0.7%) compared with North Americans (15%) [7]. Among Asians in Singapore, DVT prevalence among hospitalized patients (15.8 per 10,000 admissions) [8] and incidences following total knee replacement (14%) [9], major colorectal surgery (3%) [10] and cranial procedures (5%) [11] were lower compared with Caucasian data. This has led to the suggestion that DVT after stroke in Asians is not common.…”

Section: Introductionmentioning

confidence: 99%

Deep Vein Thrombosis following Ischemic Stroke among Asians

et al. 2006

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Background: Deep vein thrombosis (DVT) is perceived as uncommon among Asian stroke patients. However, there is a paucity of published data, and thus, we studied the frequency, characteristics and prognosis of DVT following ischemic stroke in Asian patients with lower limb paresis. Methods: Doppler ultrasound scans of the lower limbs were performed at days 7–10 and 25–30 after stroke onset. The functional status of patients was assessed at 6 months using the modified Rankin scale. Results: DVT was detected in 30% of patients at days 7–10 and in 45% of patients at days 25–30. Most thromboses were distal. There were significant associations of age and degree of weakness with the presence of DVT at days 25–30, but not at days 7–10. DVT in the first month after stroke was associated with poorer outcome at 6 months. Conclusions: DVT following ischemic stroke among Asians is common and associated with poor functional outcome.

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Randomized, controlled trial of low molecular weight heparin vs. no deep vein thrombosis prophylaxis for major colon and rectal surgery in Asian patients

Abstract: Deep venous thrombosis prophylaxis is needed in Asian patients undergoing major colorectal surgery.

Cited by 70 publications

References 22 publications

Safety and Efficacy of Fondaparinux for Prophylaxis of Venous Thromboembolism after Colorectal Cancer Resection: A Propensity Score Matched Analysis

Safety and Efficacy of Fondaparinux for Prophylaxis of Venous Thromboembolism after Colorectal Cancer Resection: A Propensity Score Matched Analysis

Epidemiology of post-operative venous thromboembolism in Asian patients. Results of the SMART venography study

Deep Vein Thrombosis following Ischemic Stroke among Asians

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