Randomized Controlled Trial of Polyethylene Glycol versus Oral Sodium Phosphate for Bowel Preparation in Unsedated Colonoscopy

Yan, Dong; Tao, Ke; Chen, Geng; Zhang, Luping; He, Qiang; Xu, Hong

doi:10.1155/2020/6457079

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…( 16) Dong et al (2020) showed no significant difference in Polyethylene glycol and sodium phosphate solution preparations. (17) The present study observed that the male ratio for colonoscopy was higher than the females. Similar results were observed in the previous study.…”

Section: Discussionsupporting

confidence: 41%

Bowel Preparations for Colonoscopy: Current Medical Practices in Pakistani Hospital Settings

Naz¹,

Tasneem²,

Khan³

et al. 2022

PJMHS

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Aim: To evaluate the quality of bowel preparations concerning the Boston Bowel Preparation Score (BBPS) and to analyze the administration, ease, palatability, and side effects of practices. Study design: Cross-sectional study Place and Duration: this study was conducted in Liaquat University of Medical and Health Sciences Jamshoro from October 2021 to March 2022 Methodology: The present study incorporated 132 patients who visited the hospital for a colonoscopy. Patients above 18 years of age were included, whereas patients with surgical procedures were excluded from the study. Participants were evaluated through pre-designed proforma for demography, dietary recommendations, side effects, procedure indications, bowel preparations, and patient ease of the bowel preparations. BBPS was used to access the bowel preparation. A score ≥ 5 was regarded as satisfactory. Results: Out of 132 patients, 73 (55.3%) were males. Seventy-one (53.8%) patients received Polyethylene glycol-based bowl preparation, and sixty-one (46.2%) patients received sodium phosphate-based preparation. Chronic constipation was the most typical cause of colonoscopy. Common side effects were vomiting (12.1%), nausea (1.5%), and bloating (3%). More than half of them responded that the preparations were palatable. A satisfaction rate of 80.3% was observed in patients with both preparations. BBPS of above five was observed in 109 (82.6%) patients. Conclusion: Polyethylene glycol and sodium phosphate preparations have been widely used in clinical practices for cleansing the colon. Sodium phosphate-based preparation was found more effective. Keywords: Bowel cleansing agents, Colonoscopy, Endoscopy, Polyethylene Glycol, Sodium phosphate.

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Section: Discussionsupporting

confidence: 41%

Bowel Preparations for Colonoscopy: Current Medical Practices in Pakistani Hospital Settings

Naz¹,

Tasneem²,

Khan³

et al. 2022

PJMHS

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“…Reviewing the literature, one concludes that polyethylene glycol (PEG) is the most extensively studied synthetic polymer for hydrogel development and application ( Figure S1B ). The hydrophilic polyether, with a repeat unit of –CH 2 CH 2 O–, has low toxicity and numerous biomedical applications [ 5 , 6 , 25 , 26 , 27 , 28 , 29 ]. Insoluble hydrogel networks can be generated by crosslinking PEG end-capped with acrylate groups (PEG-diacrylate (PEGDA)).…”

Section: Introductionmentioning

confidence: 99%

Elucidating the Molecular Mechanisms for the Interaction of Water with Polyethylene Glycol-Based Hydrogels: Influence of Ionic Strength and Gel Network Structure

2021

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The interaction of water within synthetic and natural hydrogel systems is of fundamental importance in biomaterial science. A systematic study is presented on the swelling behavior and states of water for a polyethylene glycol-diacrylate (PEGDA)-based model neutral hydrogel system that goes beyond previous studies reported in the literature. Hydrogels with different network structures are crosslinked and swollen in different combinations of water and phosphate-buffered saline (PBS). Network variables, polyethylene glycol (PEG) molecular weight (MW), and weight fraction are positively correlated with swelling ratio, while “non-freezable bound water” content decreases with PEG MW. The presence of ions has the greatest influence on equilibrium water and “freezable” and “non-freezable” water, with all hydrogel formulations showing a decreased swelling ratio and increased bound water as ionic strength increases. Similarly, the number of “non-freezable bound water” molecules, calculated from DSC data, is greatest—up to six molecules per PEG repeat unit—for gels swollen in PBS. Fundamentally, the balance of osmotic pressure and non-covalent bonding is a major factor within the molecular structure of the hydrogel system. The proposed model explains the dynamic interaction of water within hydrogels in an osmotic environment. This study will point toward a better understanding of the molecular nature of the water interface in hydrogels.

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“…patients in the OSP group. 15 In this study, we observed that the largest number of colonoscopies was performed at the age of 40-60, and most of them were male. It can be concluded from previous studies that men have the highest detection rate of adenoma compared with women of the same age group.…”

Section: Discussionmentioning

confidence: 72%

Sodium phosphate a better choice for bowel preparation before colonoscopy as compared to polyethyleneglycol (PEG).

Tariq¹,

Zaheer

Khan³

et al. 2022

TPMJ

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Objective: To compare the frequency of good to excellent quality of bowel preparation before colonoscopy in PEG versus sodium phosphate. Study Design: Randomized Controlled Trial. Setting: Department of Gastroenterology, Doctors Hospital and Medical Center, Lahore Pakistan. Period: March 2019 to December 2019. Material & Methods: 180 patients was selected by non-probability consecutive sampling and randomly divided in to two groups: group A (4L of polyethylene glycol (PEG) in a split dose fashion, i.e. 2L a day before colonoscopy and 2 L given 4-6 hours before colonoscopy) group B (2 doses of 20ml sodium phosphate 12hours apart before colonoscopy) using random number table. The attending gastroenterologist scored the different segment of colon cleansing by using the Boston Bowel Preparation Scale (BBPS). Data collected is analyzed by Statistical Package of Social Sciences (SPSS). Results: Among 90 patients who used sodium phosphate as bowel cleansing agent, 75 (83.3%) patient showed good to excellent result as compared with 90 patients who used PEG revealed the following result 71 (78.9%). p value was 0.44 revealing that there is no significant difference among both bowel preparation agents. Conclusion: Sodium phosphate can be used as an alternative agent in most of settings where PEG cannot be used either due to patient preference or due to its side effects.

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Randomized Controlled Trial of Polyethylene Glycol versus Oral Sodium Phosphate for Bowel Preparation in Unsedated Colonoscopy

Cited by 8 publications

References 24 publications

Bowel Preparations for Colonoscopy: Current Medical Practices in Pakistani Hospital Settings

Bowel Preparations for Colonoscopy: Current Medical Practices in Pakistani Hospital Settings

Elucidating the Molecular Mechanisms for the Interaction of Water with Polyethylene Glycol-Based Hydrogels: Influence of Ionic Strength and Gel Network Structure

Sodium phosphate a better choice for bowel preparation before colonoscopy as compared to polyethyleneglycol (PEG).

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