Randomized Controlled Trial on the Effects of Tualang Honey and Hormonal Replacement Therapy (HRT) on Cardiovascular Risk Factors, Hormonal Profiles and Bone Density Among Postmenopausal Women: A Pilot Study

Hussain, Nik Hazlina Nik; Sulaiman, Siti Amrah; Hassan, Intan Idiana; Kadir, Azidah Abdul; Nor, Norhayati Mohd; Ismail, Suzylawati; Yaacob, Lili Husniati; Zakaria, Rahimah; Shafie, Nazlah Shaniza; Haron, Juhara; Musa, Kamarul Imran

doi:10.5539/jfr.v1n2p171

Cited by 15 publications

(16 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean duration of menopause was 12.13, with a range between 3 and 44 years. In a previous study, the mean duration of menopause was 5.8 years (20). The present study revealed that postmenopausal women are at increased risk of long-term effects such as osteoporosis.…”

Section: Discussionsupporting

confidence: 59%

Bone Health Status among Postmenopausal Women in Malaysia

Nurumal

Isa

Hatta

et al. 2019

International Journal of Women’s Health and Reproduction Scienc

View full text Add to dashboard Cite

Objectives: The study has evaluated bone health status among post-menopausal women in a public hospital of Malaysia. Materials and Methods: A total of 116 post-menopausal women, who met the criteria, participated in this study. The purposive sampling method was used to achieve the criteria of participants. Results: This cross-sectional study revealed that more than half of the respondents (52.6%, n=61) had osteopenia; whereas, 47.4% (n=55) of the respondents had osteoporosis. There was a significant correlation between the age and menopausal years with the bone health status (i.e. P=0.004 and P=0.028, respectively) in postmenopausal women. Conclusions: Menopausal women experienced deterioration of bone mineral density (BMD) with advancing age and menopausal years.

show abstract

Section: Discussionsupporting

confidence: 59%

Bone Health Status among Postmenopausal Women in Malaysia

Nurumal

Isa

Hatta

et al. 2019

International Journal of Women’s Health and Reproduction Scienc

View full text Add to dashboard Cite

show abstract

“…The present finding of lower level of serum LH in the J 80 compared to J 20 , HJ 20 and HJ 80 implied that high intensity jumping exercise without honey supplementation may have elicited negative effects on serum LH. This result implies that honey, a high concentrated source of energy with 313 calories per 100 g and antioxidants such as flavonoids and phenolic acid [ 24 ] may have potential to elicit beneficial effects on reduction of adverse effect induced by high intensity jumping exercise.…”

Section: Discussionmentioning

confidence: 99%

“…Chepulis and Starkey [ 23 ] reported that honey feeding alone has shown its beneficial effects on bone mineral density in animals. Additionally, two previous studies have shown that honey has similar effects with hormone replacement therapy on bone densitometry [ 24 ] and prevents uterine atrophy in postmenopausal state [ 25 ]. Nevertheless, these previous studies did not report the underlying mechanisms that could explain the increase in bone mass by honey feeding.…”

Section: Introductionmentioning

confidence: 99%

Effects of honey supplementation combined with different jumping exercise intensities on bone mass, serum bone metabolism markers and gonadotropins in female rats

Mosavat

Ooi

Mohamed

2014

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundThe effects of high and low jumping exercise intensities combined with honey on bone and gonadotrophins were investigated in eighty four 9 week-old female rats.MethodsThe experimental groups were 20 or 80 jumps per day combined with or without honey supplementation (HJ20, HJ80, J20 and J80), honey supplementation (H), sedentary without supplementation control (C), and baseline control (C0) groups.ResultsStudy results showed that HJ80 elicited greatest beneficial effects on tibial and femoral mass, serum total calcium and alkaline phosphatase concentrations. There were significantly (p < 0.05) lower levels of serum follicle stimulating hormone concentrations in H, J20, J80 compared to C, with exception of HJ20 and HJ80. Serum luteinizing hormone concentrations were significantly (p < 0.05) greater in HJ20, HJ80 and J20 compared to J80.ConclusionsIt appears that high intensity jumping exercise combined with honey supplementation resulted more discernable effects on bone. Meanwhile, honey may protect against the adverse effects induced by jumping exercise on gonadotropins in female rats.

show abstract

“…Ariefdjohan et al [10] reported that honey has the potential to increase calcium absorption after 2 days of acute feeding in rats. In addition, Hussain et al [11] reported that honey has similar effects with hormone replacement therapy on bone densitometry in postmenopausal women. Therefore, it was hypothesized that honey may play a role in increasing bone health.…”

mentioning

confidence: 99%

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Tavafzadeh¹,

Ooi

Chen³

et al. 2015

JESO

View full text Add to dashboard Cite

Open Access Research Articleactivity is through modification in bone turnover which occurs through two fundamentally different processes, i.e. modeling and remodeling with the activities of osteoblast and osteoclast cells in the mechanisms of bone formation and bone resorption [3]. A number of biochemical assays have been described for measuring serum and urinary concentration of markers of bone metabolism [4] that allow a good estimation of bone metabolic processes and have been established as useful parameters in assessing changes in bone turnover. To date, the mechanisms by which combined exercise and dietary intake lead to changes in bone metabolism are not fully understood.Nutritional supplementation is another main factor associated with bone health and development. Aoe et al. [5] reported that as compared to drugs that have a rapid effect, administration of nutrients related to bone metabolism is relatively safe and inexpensive. To date, the effects of different types of supplementation such as calcium, vitamin D, milk, soy and soy protein on bone mass, turnover and mineral density have been reported [6][7][8][9]. One of the nutrients that has long tradition of use within various medical systems and prescribed for variety of uses from ancient time is honey. Ariefdjohan et al. [10] reported that honey has the potential to increase calcium absorption after 2 days of acute feeding in rats. In addition, Hussain et al. [11] reported that honey has similar effects with hormone replacement therapy on bone densitometry in postmenopausal women. Therefore, it was hypothesized that honey may play a role in increasing bone health.Tualang honey is a wild, multi floral honey produced by Apis dorsata bees that form hives on the branches of giant trees named Tualang in the Malaysian rainforest, and it has been reported recently that ovariectomized rats that received Tualang honey showed greater improvements in trabecular bone structure than rats receiving calcium [12], implying the beneficial effects of Tualang honey supplementation on bone. Nevertheless to date, administration of Tualang honey in combination with exercise on bone health and antioxidant status in rats has not been investigated, thus the present study was proposed. AbstractPurpose: To investigate the effects of combined jumping exercise and honey supplementation on bone metabolism and antioxidant status in female rats.

show abstract

Randomized Controlled Trial on the Effects of Tualang Honey and Hormonal Replacement Therapy (HRT) on Cardiovascular Risk Factors, Hormonal Profiles and Bone Density Among Postmenopausal Women: A Pilot Study

Cited by 15 publications

References 40 publications

Bone Health Status among Postmenopausal Women in Malaysia

Bone Health Status among Postmenopausal Women in Malaysia

Effects of honey supplementation combined with different jumping exercise intensities on bone mass, serum bone metabolism markers and gonadotropins in female rats

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Contact Info

Product

Resources

About