Randomized controlled trial to study plaque inhibition in calcium sodium phosphosilicate dentifrices

Abstract

General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Methods:This was an exploratory, single-centre, examiner-blind, randomised, controlled, five treatment period, crossover, plaque re-growth study, with supervised use of study products. Twenty-three healthy adult volunteers were randomized to receive experimental 5% CSPS dentifrice; two marketed 5% CSPS dentifrices; active comparator mouthrinse and negative control dentifrice. At the start of each treatment period, zero plaque was established by dental prophylaxis and study products were dispensed as either dentifrice slurries or mouthrinse, twice daily for the next 4 days. No other forms of oral hygiene were permitted.After 96 hours, supra-gingival plaque was determined by plaque area (direct entry, planimetric method) and TPI. Changes from zero plaque were analysed.Results: For both measures, plaque re-growth at 96 hours was significantly lower following treatment with active comparator mouthrinse and significantly higher following treatment with the experimental 5% CSPS dentifrice, compared to all other treatments. There were no statistically significant differences between the three other treatments, except between the marketed 5% CSPS dentifrices, for overall plaque area. Conclusions:The comparator mouthwash was significantly more effective at preventing plaque accumulation than the dentifrice slurries. The three marketed dentifrices contained sodium lauryl sulphate and were more effective at reducing plaque re-growth than the experimental dentifrice formulated with a tegobetaine/adinol surfactant system. 5 Clinical relevanceThe CSPS containing dentifrices tested in this study showed no significant chemicaltherapeutic anti-plaque benefits compared to a negative control dentifrice. However, sodium lauryl sulphate-containing dentifrices controlled plaque more effectively than a tegobetaine/adinol-containing CSPS dentifrice suggesting that the impact of surfactant selection on anti-plaque activity of formulations warrants further investigation. NHS REC Reference: 12/SW/0294 6

Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching

“…These glasses form an integrated bond with hard tissue through the formation of a carbonated hydroxyapatite layer on tissue surfaces following immersion in physiological solutions 13 . This hydroxyapatite layer, in turn, is generally thought to help protein binding, leading to the formation of a tight bond with the enamel 8 . Therefore, further studies must be conducted to evaluate the dissolution mechanism of NovaMin.…”

A proof of concept study to confirm the suitability of an intra oral scanner to record oral images for the non-invasive assessment of gingival inflammation

“…The acquisition of digital data with IOS represents a novel methodology to unequivocally capture and store source data from the gingival tissues more rapidly than standard non-invasive clinical records with enough detail to enable clinicians to also assess a multitude of other oral health parameters used to evaluate oral health. This addresses the shortcomings of most oral health studies using conventional assessment indices, in that they lack objectivity, comparability and validity [26]. IOS furthermore, may record data at an instant as per observational studies or in sequence, as per intervention studies.…”