Randomized Crossover Study of Effect of Resistance Training on Glycemic Control, Muscular Strength, and Cholesterol in Type I Diabetic Men

Abstract

The goal of this study was to evaluate a program of resistance weight training on cardiovascular risk factors, blood glucose management, and overall strength in diabetic subjects. A randomized crossover design was performed on eight male type I (insulin-dependent) diabetic subjects (mean +/- SD age 31 +/- 3.5 yr, height 176 +/- 5.6 cm, body wt 80 +/- 15 kg, duration of diabetes 12.3 +/- 9.8 yr, and insulin dose 24 U NPH/day and 21 U regular/day). The program consisted of heavy-resistance weight training 3 days/wk for 10 wk, concentrating on the strengthening of major muscle groups through progressive resistance. Blood tests included total cholesterol, triglycerides, very-low-density lipoprotein and high-density lipoprotein cholesterol, and HbA1c. These tests were repeated at three time points during the program. Field-strength testing was performed before and after training. An improvement was seen in the squat (93.6% increase, P less than 0.0001) and bench press (58% increase, P less than 0.005). HbA1c and triglyceride levels showed no change during the resting portion of the experiment but showed a significant change with the training program: HbA1c 6.9 +/- 1.4 vs 5.8 +/- 0.9% (P = 0.05) and triglyceride 5.044 +/- 1.06 vs. 4.628 +/- 0.88 mM (P = 0.01). Self-monitored glucose (taken pre- and postexercise) showed a decrease from 7.85 +/- 3.13 to 7.05 +/- 2.91 mM (P = 0.0001). Very-low-density lipoprotein cholesterol and triglycerides did not change after training. Analysis of variance showed no significant differences over time from the three time points with regard to reductions in cardiovascular risk factors or HbA1c.(ABSTRACT TRUNCATED AT 250 WORDS)

Physical Activity Capture Technology With Potential for Incorporation Into Closed-Loop Control for Type 1 Diabetes

“…In addition, glucose lowering is rapid with aerobic exercise. 16,17 However, only 4 studies have studied the impact of both aerobic and anaerobic training in the same patients with T1D. [18][19][20][21] Reports from these studies to date have not provided estimates of rate of change in plasma or interstitial fluid glucose in the same individual with aerobic and resistance activity under otherwise comparable dietary and insulin managements conditions.…”

Exercício aeróbico ou com pesos melhora o desempenho nas atividades da vida diária de mulheres idosas

“…The scientific evidence has been well-established, demonstrating the benefits of the regular practice of resistance exercises in the apparently healthy population 5,6 and even in those individuals with non-transmissible chronic 7 orinfecto-contagious diseases 8,9 . The classical studies point benefits such as decrease of body adiposity 10 , increase of muscle strength 11 , increase of the individual myocyte size 12 , decrease of the number of falls 13 , increase of bone mineral density 14 , shorter time of gastrointestinal transit 15 , improvement of the glycolized hemoglobin response 16 , besides increase of functional capacity 17 . Even though, the aerobic exercises still have been more frequently recommended.…”

Physical Activity Across the Lifespan

“…The recent physical activity guidelines weigh the evidence across many health outcomes, including all-cause mortality, cardiorespiratory health, metabolic health, energy balance, musculoskeletal health, functional health, cancer, and mental health. For example, studies of the impact of increased physical activity for individuals with Type I or Type II diabetes indicate reduced macrovascular complications for those with Type II (e.g., Hu et al, 2004), yet any exercise prescription in Type I diabetes must address the issue of avoiding exercise-induced hypoglycemia (Durak, Jovanovic-Peterson, & Peterson, 1990). In the area of cardiorespiratory health, exercise training has been found to be an effective secondary preventive measure for those with established peripheral arterial disease (e.g., Killewich, Macko, Montgomery, Wiley, & Gardner, 2004;Tsai et al, 2002).…”