Randomized, Double‐Blind, Placebo‐Controlled, Clinical Trial of D‐α‐Tocopherol (Vitamin E) as Add‐on Therapy in Uncontrolled Epilepsy

Raju, Garuda Butchi; Behari, Madhuri; Prasad, Kameshwar; Gk, Ahuja

doi:10.1111/j.1528-1157.1994.tb02446.x

Cited by 35 publications

(19 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, clinical trials have yielded conflicting results for the effect of α-tocopherol as an adjunctive antiepileptic agent. Ogunmekan and Hwang (1989) reported that α-tocopherol supplementation significantly reduced seizures; however, Raju et al (1994) did not show any significant difference between α-tocopherol and placebo. Although both trials were done in refractory epileptic patients, Ogunmekan and Hwang (1989) enrolled child patients, whereas Raju et al (1994) enrolled adult patients.…”

Section: Antioxidant Strategy For Seizurementioning

confidence: 91%

“…Ogunmekan and Hwang (1989) reported that α-tocopherol supplementation significantly reduced seizures; however, Raju et al (1994) did not show any significant difference between α-tocopherol and placebo. Although both trials were done in refractory epileptic patients, Ogunmekan and Hwang (1989) enrolled child patients, whereas Raju et al (1994) enrolled adult patients. Moreover, the duration of α-tocopherol supplementation was limited to 3 months (Raju et al, 1994), which may be too short for precise evaluation of the effect of α-tocopherol.…”

Section: Antioxidant Strategy For Seizurementioning

confidence: 91%

“…Although both trials were done in refractory epileptic patients, Ogunmekan and Hwang (1989) enrolled child patients, whereas Raju et al (1994) enrolled adult patients. Moreover, the duration of α-tocopherol supplementation was limited to 3 months (Raju et al, 1994), which may be too short for precise evaluation of the effect of α-tocopherol. Thus, the effects of α-tocopherol must be examined for a longer time period.…”

Section: Antioxidant Strategy For Seizurementioning

confidence: 99%

See 2 more Smart Citations

Role of oxidative stress in epileptic seizures

Shin

Jeong

Chung

et al. 2011

Neurochemistry International

363

218

View full text Add to dashboard Cite

Oxidative stress resulting from excessive free-radical release is likely implicated in the initiation and progression of epilepsy. Therefore, antioxidant therapies aimed at reducing oxidative stress have received considerable attention in epilepsy treatment. However, much evidence suggests that oxidative stress does not always have the same pattern in all seizures models. Thus, this review provides an overview aimed at achieving a better understanding of this issue. We summarize work regarding seizure models (i.e., genetically epilepsy-prone rats, kainic acid, pilocarpine, pentylenetetrazol, and trimethyltin), oxidative stress as an etiologic factor in epileptic seizures (i.e., impairment of antioxidant systems, mitochondrial dysfunction, involvement of redox-active metals, arachidonic acid pathway activation, and aging), and antioxidant strategies for seizure treatment. Combined, this review highlights pharmacological mechanisms associated with oxidative stress in epileptic seizures and the potential for neuroprotection in epilepsy that targets oxidative stress and is supported by effective antioxidant treatment.

show abstract

Section: Antioxidant Strategy For Seizurementioning

confidence: 91%

Section: Antioxidant Strategy For Seizurementioning

confidence: 91%

Section: Antioxidant Strategy For Seizurementioning

confidence: 99%

See 1 more Smart Citation

Role of oxidative stress in epileptic seizures

Shin

Jeong

Chung

et al. 2011

Neurochemistry International

363

218

View full text Add to dashboard Cite

show abstract

“…2007;Joshi et al, 1999;Peled et al, 2001;Peterson et al, 1976;Pfeiffer and LaMola. 1983;Raju et al, 1994;Sullivan et al, 1990;Tamai et al, 1988;Gaby, 2007;Torres et al, 1999;Trimble et al, 1980;Turner et al, 1977). Several different nutrients (and two hormones) may also be beneficial in selected patients with epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Role of certain nutritional supplements and biological regulators in the epilepsy

Asif¹

2013

TANG [HUMANITAS MEDICINE]

View full text Add to dashboard Cite

Certain dietary contents, biological supplements might influence the occurrence or treatment of epilepsy. Some studies have found that the supplementation with individual nutrients reduced seizure frequency or improved other aspects of health in patients with epilepsy. Potentially beneficial dietary interventions include treating blood glucose dysregulations. Identifying and avoiding allergenic foods, and avoiding suspected triggering agents such as alcohol, aspartame, and monosodium glutamate. The Atkins diet (very low in carbohydrates) is a less restrictive type diet that may be effective in some cases. Nutrients that may reduce seizure frequency include vitamin B6, magnesium, vitamin E, manganese, taurine, dimethylglycine, and omega-3 fatty acids. Administration of thiamine may improve cognitive function in patients with epilepsy. Supplementation with folic acid, vitamin B6, biotin, vitamin D, and L-carnitine may be needed to prevent or treat deficiencies resulting from the use of anticonvulsant drugs. Vitamin K1 has been recommended near the end of pregnancy for women taking anticonvulsants. Melatonin may reduce seizure frequency in some cases, and progesterone may be useful for women with cyclic exacerbations of seizures. In most cases, nutritional therapy is not a substitute for anticonvulsant medications. However, in selected cases, depending on the effectiveness of the interventions, dosage reductions or discontinuation of medications may be possible. However, nutrient supplementation may be necessary to prevent or reverse the effects of certain deficiencies that frequently result from the use of antiepileptic drugs.

show abstract

“…It delayed the onset of seizures in the intracerebral ferrous chloride model, but not in the animal models commonly used to screen for anticonvulsant drug actions. However, a double‐blind placebo‐controlled, cross‐over trial (Raju et al, 1994) with vitamin E as add‐on therapy in 43 patients with uncontrolled epilepsy demonstrated no efficacy with regard to seizure control.…”

Section: Vitamins and Other Nutrients In Patients With Epilepsy (Tablmentioning

confidence: 99%

Nutritional supplements, foods, and epilepsy: Is there a relationship?

2008

View full text Add to dashboard Cite

Summary Anecdotal reports suggest that certain foods and dietary contents might influence the occurrence of seizures. However, the existing data are scanty and sometimes controversial. Some studies have found that the supplementation with individual nutrients reduced seizure frequency or improved other aspects of health in patients with epilepsy, while other studies have failed to confirm those findings. Nutrient supplementation may be necessary to prevent or reverse the effects of certain deficiencies that frequently result from the use of antiepileptic drugs (AEDs). However, the potential benefits of nutrient supplementation in patients with epilepsy must be weighed against reports that large doses of certain nutrients can interfere with the action of some AEDs. This paper reviews dietary and nutritional considerations in patients with epilepsy and also the relationship between foods, dietary elements, and seizures.

show abstract

Randomized, Double‐Blind, Placebo‐Controlled, Clinical Trial of D‐α‐Tocopherol (Vitamin E) as Add‐on Therapy in Uncontrolled Epilepsy

Cited by 35 publications

References 22 publications

Role of oxidative stress in epileptic seizures

Role of oxidative stress in epileptic seizures

Role of certain nutritional supplements and biological regulators in the epilepsy

Nutritional supplements, foods, and epilepsy: Is there a relationship?

Contact Info

Product

Resources

About