Randomized, Double-Blind, Placebo-Controlled Trial of Sildenafil (Viagra®) for Erectile Dysfunction After Rectal Excision for Cancer and Inflammatory Bowel Disease

Lindsey, Ian; George, Bruce; Kettlewell, M. G. W.; Mortensen, Neil

doi:10.1007/s10350-004-6287-9

Cited by 109 publications

(74 citation statements)

References 16 publications

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“…Psychological evaluation and support of the patient and his or her partner are mandatory, resulting in enhancing the response to pharmacologic therapy (Eveno, Lamblin, Mariette, & Pocard, 2010). Among the medications available, the efficacy of sildenafil was demonstrated in a study where 32 patients were randomized to medical treatment or placebo after rectal resection (Lindsey et al, 2002). Erectile potency improved in 80% of patients treated with sildenafil compared with 17% of patients treated with placebo (Lindsey et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…A number of investigations report on the expanded role of using a vacuum erection device (VED) as combined therapy with a PDE5i for penile rehabilitation after RP (Kohler et al, 2007;Pahlajani et al, 2010). The ability of PDE5i and VED to aid in the return of erections after nerve-sparing RP has been established and may benefit rectal cancer patients with ED after surgery (Lindsey, George, Kettlewell, & Mortensen, 2002;Traa, De Vries, Roukema, & Den Oudsten, 2012). Penile rehabilitation, defined as the use of any drug or device after radical resection for rectal cancer to maximize the recovery of sexual function, is warranted.…”

Section: Research-article2016mentioning

confidence: 99%

See 1 more Smart Citation

Phosphodiesterase-5 Inhibitors and Vacuum Erection Device for Penile Rehabilitation After Laparoscopic Nerve-Preserving Radical Proctectomy for Rectal Cancer: A Prospective Controlled Trial

et al. 2016

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The current study sought to clarify the role of phosphodiesterase type 5 inhibitors (PDE-5i) and a vacuum erection device (VED) in penile rehabilitation after laparoscopic nerve-preserving radical proctectomy (LNRP) for rectal cancer. Participants were assigned to one of the following arms-no-intervention, nightly use of sildenafil 25 mg for 3 months after surgery, or concurrent use of nightly sildenafil 25 mg/day for 3 months and a vacuum erection device (VED) 10 to 15 minutes/day for 3 months-in a nonrandomized fashion. All participants had a follow-up of over 12 months prospectively, and patients had baseline, 3-, 6-, and 12-month assessment based on the International Index of Erectile Function-5 (IIEF-5). Seventy-one cases were included in final analyses. In the no-intervention group, the mean baseline IIEF-5 score of 21.9 decreased rapidly to 5.0 at 3 months (p < .001), 9.2 at 6 months (p < .001), and stayed at 10.9 at 12 months (p < .001). In the single therapy group, the mean baseline IIEF-5 score of 22.4 decreased dramatically to 9.0 at 3 months (p < .001), 14.9 at 6 months (p = .005), and stayed at 15.1 at 12 months (p = .005). In the combined therapy group, the mean baseline IIEF-5 score of 23.0 decreased slightly to 15.0 at 3 months (p = .005), 18.0 at 6 months (p = .038), and maintained at 18.7 at 12 months (p = .163). Findings suggested an over 50% decline in the quality of erection function of the patients after LNRP. The early use of PDE-5i alone or combined use of PDE-5i and VED after LNRP maintained erectile function at 12 months.

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Section: Discussionmentioning

confidence: 99%

Section: Research-article2016mentioning

confidence: 99%

Phosphodiesterase-5 Inhibitors and Vacuum Erection Device for Penile Rehabilitation After Laparoscopic Nerve-Preserving Radical Proctectomy for Rectal Cancer: A Prospective Controlled Trial

et al. 2016

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“…In general there is a good response in 87% of patients, but the effect of such a drug is dependent on, at least partially, intact cavernous nerves to produce nitric oxide. Erectile function was satisfactorily improved by use of sildenafil (Viagra) only in 79% of male patients with ED after rectal excision for either rectal cancer or inflammatory bowel disease [35,36].…”

Section: Resultsmentioning

confidence: 99%

Impact of Total Mesorectal Excision on Bladder and Sexual Function in Rectal Cancer

Dar¹,

Parray²,

Bhat³

et al. 2017

Cancer Surg

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“…106 Rectal excision and renal failure Rectal excision is associated with ED, probably by damaging the pelvic parasympathetic nerve. 107 Sildenafil was effective in 79% of patients with ED after rectal excision for cancer or inflammatory bowel disease. 107 In 41 patients with end-stage kidney failure and ED, but no diabetes, sildenafil…”

Section: Urogenitalmentioning

confidence: 96%

“…107 Sildenafil was effective in 79% of patients with ED after rectal excision for cancer or inflammatory bowel disease. 107 In 41 patients with end-stage kidney failure and ED, but no diabetes, sildenafil…”

Section: Urogenitalmentioning

confidence: 96%

Do vardenafil and tadalafil have advantages over sildenafil in the treatment of erectile dysfunction?

Doggrell

2006

Int J Impot Res

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Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70 years of age. Sildenafil, vardenafil and tadalafil have all been shown to be similarly effective in the treatment of men with ED of vary etiologies, to have similar adverse effects profiles, and to improve quality-oflife by similar amounts. As these phosphodiesterase 5 (PDE5) inhibitors all increase the hypotensive effects of nitrates, they are not suitable for use in patients taking nitrates for the treatment of ischaemic heart disease. All three inhibitors must be used with caution in patients taking a 1 -adrenoceptors antagonists for benign prostatic hyperplasia. Although nonarteritic anterior ischaemic neuropathy has been reported in some users of the PDE5 inhibitors, there is no conclusive evidence that PDE5 inhibitors cause this rare effect. Tadalafil has a longer half-life than sildenafil or vardenafil, and a longer duration of action than sildenafil and vardenafil. Most preference studies have shown tadalafil to be preferred, but there are serious limitations to some of these studies. One approach to treatment is to give each patient a short-and long-acting agent, and for individuals to decide their preference.

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Randomized, Double-Blind, Placebo-Controlled Trial of Sildenafil (Viagra®) for Erectile Dysfunction After Rectal Excision for Cancer and Inflammatory Bowel Disease

Cited by 109 publications

References 16 publications

Phosphodiesterase-5 Inhibitors and Vacuum Erection Device for Penile Rehabilitation After Laparoscopic Nerve-Preserving Radical Proctectomy for Rectal Cancer: A Prospective Controlled Trial

Phosphodiesterase-5 Inhibitors and Vacuum Erection Device for Penile Rehabilitation After Laparoscopic Nerve-Preserving Radical Proctectomy for Rectal Cancer: A Prospective Controlled Trial

Impact of Total Mesorectal Excision on Bladder and Sexual Function in Rectal Cancer

Do vardenafil and tadalafil have advantages over sildenafil in the treatment of erectile dysfunction?

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