Randomized placebo-controlled clinical study on enhancement of Medha (intelligence quotient) in school going children with Yahstimadhu granules

Abstract

Introduction:Optimal intelligence is a vital essentiality in day-to-day life, especially in children who have to build up their life in an apt manner. Yashtimadhu (Glycyrrhiza glabra Linn) is a time tested classical drug indicated for promotion of mental health mentioned in Ayurveda which may also help children to attain optimal intelligence.Aim:To evaluate the role of Yashtimadhu (Glycyrrhiza glabra Linn.) granules in enhancement of Medha (intelligence quotient [IQ]).Materials and Methods:The study was conducted on healthy school going children aged 14–16 years. Total 94 children were registered and divided into two groups. Yashtimadhu granules was administered in Group A and Wheat flour in the form of granules in Group B, the duration of treatment was 12 weeks with follow up of additional 12 weeks. Objective parameters included assessment of functional aspects of Buddhi (psychological faculty for reasoning and logic) along with the assessment of IQ, Quality of life parameters and general health condition.Results:Yashtimadhu granules showed statistically highly significant results in improving functional aspects of Buddhi, IQ, several aspects of quality of life parameters and health. The number needed to treat (NNT) with Yashtimadhu granules for children achieving an IQ score of 90 and above was 3.38, suggesting one in every 3.38 patients had achieved this target and for children achieving an IQ score of 110 and above the NNT was 6.66.Conclusion:Yashtimadhu granules was safe throughout the course of study and indeed possessed a significant efficacy in improving Medha (IQ).

Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model

“…Indian Ayurvedic system classifies plants with neuroprotective properties as Medhya Rasayana , which includes, Yashtimadhu, Glycyrrhiza glabra ; Mandukaparni, Centella asiatica and, Guduchi, Tinospora cordifolia [ 4 , 5 ]. Yashtimadhu powder is prepared from licorice root is known for its potential as neuroprotective, memory enhancer, and immunomodulatory effects [5] , [6] , [7] , [8] . The data explored the cellular toxicity of rotenone and neuroprotection by Yashtimadhu.…”

Comparative Study of Efficacy of Jatamansi (Nardostachys jatamansi DC) and Imipramine in Generalized Anxiety Disorder (G.A.D.): A Randomized Controlled Double Blind Clinical Trial

“…Various herbs mentioned in the Ayurveda proved its potential to work on anxiety. Various researches validated of Bramhi (Bacopa monniera) [4], Vacha (Acorus calamus) [5,6,7] Jatamansi (Nardostachys jatamansi) [8], Mandukparni (centella aciatica) [9], Tagar (Velerenial velchii), Kawa(Piper methystium), Ashwagandha (Withenia somnifera), Shunthi (Zinziber officinale) [10] Kaitarya (Myricanagi) [11], Chorak (Angelica glauca), Hingu (Ferula narthex) [12], Yashtimadhu (Glycerriza glabra) [13] are effective CNS acting herbs with the anxiolytic activities.…”

Clinical Assessment of Herbal Formulation in Reducing Oxidative Stress Causing Spermatogenetic Disorders Using the Ros, D- Roms and Mda Tests

“…Liqourice also contains glucose, sucrose, resins, mannite, asparagines and fats. [17][18][19][20] Hence, an Ayurvedic formulation having equal amounts of roots of Sida cordifolia Linn. and Glycyrrhiza glabra Linn.…”