Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

Alves, Rubina; Grimalt, Ramón

doi:10.1097/dss.0000000000000665

Cited by 194 publications

(220 citation statements)

References 35 publications

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“…Various studies in the literature indicated that PRP stimulates a number of active features such as growth rate, hair count, hair density, hair shaft diameter, hair root strength, anagen hair, telogen hair, terminal hair density, epidermal keratinocytes, hair follicular bulge cells, and lead to increase in small blood vessels in hair follicle, prevents dermal papilla apoptosis, extent anagen phase, and enhances hair regrowth [70][71][72][73][74]. The carrier which contains dalteparin/protamine micro particles (DP MP) (low-molecular-weight heparin) was used to enhance the efficiency of PRP.…”

Section: The Mechanism Of Platelet-rich Plasma In Androgenetic Alopeciamentioning

confidence: 99%

Cosmetic Procedures in the Treatment of Alopecia

Kartal¹,

Altunel²,

Gençler³

2017

Hair and Scalp Disorders

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Alopecia has a significant negative impact on the quality of life. Unfortunately, there is no satisfactory cure for most types of alopecia. Alopecia is divided into cicatricial and noncicatricial types. Androgenetic alopecia, alopecia areata, and telogen effluvium are common forms of noncicatricial alopecias. In order to treat or improve the appearance, various procedures that are being applied for different types of alopecia including mesotherapy, microneedling, platelet-rich plasma, low-level light therapy, and stem-cell therapy with variable outcomes are reviewed in this chapter.

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Section: The Mechanism Of Platelet-rich Plasma In Androgenetic Alopeciamentioning

confidence: 99%

Cosmetic Procedures in the Treatment of Alopecia

Kartal¹,

Altunel²,

Gençler³

2017

Hair and Scalp Disorders

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“…PRP is a biological product defined as a portion of the plasma fraction of autologous blood with a platelet concentration above the baseline (before centrifugation) [22]. As such, PRP contains not only a high level of platelets but also the full complement of clotting factors, the latter typically remaining at their normal, physiologic levels [23].…”

Section: Definitionmentioning

confidence: 99%

A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

Alves

Grimalt

2017

Skin Appendage Disord

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516

416

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Platelet-rich plasma (PRP) is currently used in different medical fields. The interest in the application of PRP in dermatology has recently increased. It is being used in several different applications as in tissue regeneration, wound healing, scar revision, skin rejuvenating effects, and alopecia. PRP is a biological product defined as a portion of the plasma fraction of autologous blood with a platelet concentration above the baseline. It is obtained from the blood of patients collected before centrifugation. The knowledge of the biology, mechanism of action, and classification of the PRP should help clinicians better understand this new therapy and to easily sort and interpret the data available in the literature regarding PRP. In this review, we try to provide useful information for a better understanding of what should and should not be treated with PRP.

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“…The currently available treatments for AGA are sometimes perceived as having limited effectiveness; therefore, the identification of new therapies for this pathology is of utmost importance [102,103]. New possible offline treatments for AGA, such as topical finasteride, injectable dutasteride, laser therapy and PRP, have recently emerged and have been claimed to have hair growth-promoting or anti-hair loss effects.…”

Section: Emerging Treatmentsmentioning

confidence: 99%

Androgenetic Alopecia: a Review and Emerging Treatments

Alves¹

2017

CRDOA

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Androgenetic Alopecia (AGA) is the most common noncicatricial alopecia that leads to the progressive miniaturization of the hair follicle. Scalp terminal hairs are converted into vellus hairs, primarily due to two factors: genetic predisposition and hormonal stimulation.The incidence and prevalence of AGA increases with age. The onset of AGA is gradual, and when this pathology progresses, the anagen phase shortens and the telogen phase remains constant. The shedding area varies from patient to patient and is usually most marked at the vertex in men, while women with AGA generally lose hair diffusely over the crown.Topical minoxidil and oral finasteride (5-alpha-reductase type II inhibitor) are the gold-standard therapies for AGA and are currently the only Food and Drug Administration (FDA)-approved drugs for the treatment of AGA.The currently available treatments for AGA are sometimes perceived as having limited effectiveness; therefore, the identification of new therapies for this pathology is of utmost importance.This article aims to review the pathogenesis, diagnosis of AGA and all the new emerging treatments for this entity in order to prevent its progression and improve the results of this pathology.

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Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

Abstract: Application of PRP showed a positive effect on AGA and could be regarded as an adjuvant therapy for AGA.

Cited by 194 publications

References 35 publications

Cosmetic Procedures in the Treatment of Alopecia

Cosmetic Procedures in the Treatment of Alopecia

A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

Androgenetic Alopecia: a Review and Emerging Treatments

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