Randomized, placebo‐controlled, double‐blind trial of clobetasol propionate 0.05% in the treatment of oral lichen planus

Abstract

It is possible to report that clobetasol, at this dosage, has been more effective than a placebo at provoking symptoms improvement in subjects affected by atrophic-erosive oral lesions.

Failure of rituximab in refractory erosive lichen planus

“…ELP may be associated with considerable morbidity and quality of life impairment, and can lead to severe complications such as vaginal and oesophageal stenosis or squamous cell carcinoma . High‐potency topical corticosteroids are considered first‐line treatment options for ELP; however, the use of systemic therapies, such as oral corticosteroids, retinoids, hydroxychloroquine or immunosuppressive agents [including methotrexate, mycophenolate mofetil (MMF), ciclosporin and tacrolimus], is often necessary in recalcitrant cases. Rituximab (RTX), an anti‐CD20 monoclonal antibody, is approved for the treatment of rheumatoid arthritis (RA), B‐cell lymphoma and antineutrophil cytoplasmic antibody‐associated vasculitis.…”

Efficacy and safety of Tripterygium wilfordii Hook. f. for oral lichen planus: Evidence from 18 randomized controlled trials

“…Although there is no international standard to assess the overall effectiveness of OLP treatment, clinical trials are commonly based on pain assessments or measurements of erosion areas to elucidate effectiveness (Liu et al, 2013). (Arduino et al, 2018;Carbone, Goss, Carrozzo, Castellano, & Gandolfo, 2003). TGs can reduce the viscosity and clotting of blood, promote the recovery of local microcirculation, inhibit the proliferation of T cells, and reduce the level of leukocyte interleukin.…”

Clinical Management Protocol for Dental Implants Inserted in Patients with Active Lichen Planus. Part II 4‐Year Follow‐Up

“…LP is a chronic disease and patients are expected to deal with the manifestations, rather than to expect complete recovery. Corticosteroids are the first line of defense against OLP, not only as a treatment but also as a method of maintenance, as corticosteroids possess anti‐inflammatory and immunosuppressive roles. The anti‐inflammatory role is through inhibition of two main inflammatory products: leukotriens and prostaglandins.…”

“…OLP is a T cell‐mediated autoimmune disorder of uncertain etiology . Beside immune dysregulation many etiological factors may be also involved, including traumatic insults, medication, dental materials, and stress . It commonly affects buccal mucosa, tongue, and gingiva …”

“…Corticosteroids are the main treatment for symptomatic OLP . Topical steroids are considered first‐line treatment because they are more effective treating superficial inflammation, specially in EOLP . Other treatment modalities are being tried to increase the efficacy and decrease the complications of corticosteroids.…”