Randomized trial of one versus two transcervical insertions of quinacrine pellets for sterilization

Agoestina, T; Hoesni, R.Hasan M; Purwara, Benny Hasan; Santoso, Budi; Siswanto, Padjar; Dasuki, Djaswadi; Samsulhadi, A; Surya, Gede Putu

doi:10.1016/s0015-0282(02)02957-6

Cited by 6 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Quinacrine was widely used historically as an antimalarial drug, has found use in treating other diseases, and is now used in women for voluntary nonsurgical sterilization [Benagiano, 2001;Clarke et al, 2001]. The transcervical insertion of quinacrine pellets causes inflammation of the endometrium and occlusion of the fallopian tubes [Agoestina et al, 2002]. This application in developing countries has generated controversy [Cooley, 2000;Benagiano, 2001] and renewed interest in its genetic toxicology [Krishnaja and Chauhan, 2000;Clarke et al, 2001].…”

Section: Discussionmentioning

confidence: 99%

“…The genotoxicity of acridines has been studied in phage, bacteria, fungi, insects, plants, cultured mammalian cells, and mammals [Ferguson and Denny, 1991]. The recent use of the former antimalarial drug quinacrine in women as a means of nonsurgical sterilization [Benagiano, 2001;Agoestina et al, 2002] has generated renewed interest in the genetic toxicology of this compound [Krishnaja and Chauhan, 2000;Clarke et al, 2001].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Frameshift mutations induced by three classes of acridines in the lacZ reversion assay in Escherichia coli: Potency of responses and relationship to slipped mispairing models

Hoffmann

Calciano

Lawless

et al. 2003

Environ and Mol Mutagen

View full text Add to dashboard Cite

The frameshift mutagenicity of 9-aminoacridine (9AA) was compared with that of quinacrine, the acridine mustards ICR-191 and quinacrine mustard (QM), and the nitroacridine Entozon in the lacZ reversion assay in Escherichia coli. As intercalating agents, 9AA and quinacrine cause mutations through noncovalent associations with DNA. Mustards and nitroacridines form covalent adducts in DNA and give rise to different spectra of mutations. Quinacrine and 9AA most effectively induced -1 frameshifts in a run of guanine residues, with 9AA being the more potent mutagen. They also induced +G frameshifts. The acridine mustard ICR-191 was a stronger mutagen than 9AA, owing largely to its potent induction of +G frameshifts. QM induced +G frameshifts more strongly than did its nonreactive counterpart quinacrine. The nitroacridine Entozon differed from the other acridines in being a potent inducer of -2 frameshifts, but it was less effective in inducing +/-1 frameshifts. Quinacrine, although a simple intercalator, induced all five kinds of frameshift mutations detected in the assay, as did the acridine mustards. Although +A and -A frameshifts were induced, adenine runs were less susceptible to acridine mutagenesis than guanine runs. The patterns of frameshift mutagenicity in the lacZ assay are similar to those in an assay based on the reversion of mutations in the tetracycline-resistance gene of the plasmid pBR322. The similarity suggests that the responses reflect the inherent bacterial mutagenicity of the compounds in the local sequence context and are not highly dependent on the broader sequence context. The results are interpreted with respect to slipped mispairing models of frameshift mutagenesis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Frameshift mutations induced by three classes of acridines in the lacZ reversion assay in Escherichia coli: Potency of responses and relationship to slipped mispairing models

Hoffmann

Calciano

Lawless

et al. 2003

Environ and Mol Mutagen

View full text Add to dashboard Cite

show abstract

“…Evidence from a randomized controlled trial [8] indicates that a dual application of two pellets of 252 mg quinacrine into the uterine cavity 1 month apart is superior to a single pellet delivery. The procedure is reported to have a failure rate of 1-2%, although the rates for ectopic pregnancy and serious complications are equal to or less than those for transabdominal sterilization [7,9,10].…”

Section: Chemical Methodsmentioning

confidence: 99%

Transcervical sterilization

Abbott¹

2007

Current Opinion in Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

show abstract

Transcervical sterilization

Abbott

2005

Best Practice & Research Clinical Obstetrics & Gynaecol

View full text Add to dashboard Cite

The transcervical approach to permanent female sterilization has been studied for more than 150 years. Methods for accessing the tubes via this approach include blind, radiological and visual (hysteroscopic) techniques. Modalities for occluding the fallopian tubes include thermal, chemical and mechanical means. Some combination of the approach and the occlusive method define all known procedures. Initial attempts at transcervical sterilization were not widely adopted due to an inability to occlude the tube reliably, resulting in pregnancy and/or high morbidity from the procedure. Quinacrine sterilization is a procedure that is widely used in the developing world, but this has not been taken up by the developed world. There are limitations in diagnosing tubal occlusion with this technique. New methods for transcervical sterilization include the Essure and the Adiana procedures. These methods involve hysteroscopic placement of devices that rely on both mechanical occlusion and stimulation of tissue ingrowth to effect tubal occlusion. These new devices can be delivered to more than 90% of tubes, have very high success rates of pregnancy prevention (>99% in studies to date) and are acceptable to patients. Most importantly, they can be fitted under local anaesthesia in an ambulatory setting. The cost advantages of transcervical sterilization have not yet been investigated. It is possible that such a modality for permanent female sterilization may be demonstrated to be highly cost-effective.

show abstract

Randomized trial of one versus two transcervical insertions of quinacrine pellets for sterilization

Cited by 6 publications

References 12 publications

Frameshift mutations induced by three classes of acridines in the lacZ reversion assay in Escherichia coli: Potency of responses and relationship to slipped mispairing models

Frameshift mutations induced by three classes of acridines in the lacZ reversion assay in Escherichia coli: Potency of responses and relationship to slipped mispairing models

Transcervical sterilization

Transcervical sterilization

Contact Info

Product

Resources

About