Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring

Hartmann, Alexander; Hartmann, Christiane; Secci, Riccardo; Hermann, Andreas; Fuellen, Georg; Walter, Michael

doi:10.3389/fgene.2021.686320

Cited by 54 publications

(29 citation statements)

References 142 publications

(201 reference statements)

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“…Owing to the complexity of the aging process and no universally acceptable single-measurement biomarker of aging is presently known ( 45 ), the evidence from several findings, in both animal and human liver specimens, has indicated the presence of specific aging hallmarks in the diseases involving the hepatic compartments; thus, the liver is regarded as an important organ for use in evaluating the aging biomarkers ( 45 – 47 ). D-Gal-induced aging in mice can cause hepatic cell swelling, necrosis, inflammatory cell infiltration, and other pathological changes, leading to liver damage ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice

Tung

Yen

et al. 2022

Front. Nutr.

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This study aimed to examine the chemical and anti-aging properties of chicken essence (CE) prepared with Sesamum indicum, Angelica acutiloba, and Zingiber officinale (HCE). HCE was analyzed for nutritional and phytochemical composition, and its anti-aging effects were investigated on the D-galactose (Gal)-induced aging mice. Results showed that HCE possessed significantly higher calories and contents of valine and total phenols than CE; it also contained significant amounts of ferulic acid, sesamin, and sesamolin. HCE significantly decreased MDA and NO levels in serum and liver and increased liver GSH levels in the D-Gal-induced mice. HCE greatly enhanced SOD and CAT activities in serum and liver, and liver GPx activity, as well as upregulating SIRT1 expression and downregulating TNF-α, IL-1β, IL-6, iNOS, Cox-2, and MCP-1 expression in liver tissues. This study demonstrates that HCE was effective in suppressing the aging process through enhancing antioxidant and anti-inflammatory activities and modulating the aging-related gene expression.

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Section: Discussionmentioning

confidence: 99%

Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice

Tung

Yen

et al. 2022

Front. Nutr.

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“…Biological age aims to account for interindividual heterogeneity in health and can markedly contrast chronological age. In the past recent decades, extensive research efforts have been made to formulate reliable predictors of biological age (8,38). To this aim, advances in molecular biology have identified associations between patient fitness or frailty and omics data, such as DNA methylation, gene expression profiles, and protein glycosylation (39)(40)(41)(42).…”

Section: Discussionmentioning

confidence: 99%

Association of Biological Age with Tumor Microenvironment in Patients with Esophageal Adenocarcinoma

Ravensbergen

Holstein

Hagenaars

et al. 2022

Preprint

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Biological age-related adaptations have been shown to modulate the non-malignant cells comprising the tumor microenvironment (TME). In the current work, we studied the association between biological age and TME characteristics in patients with esophageal adenocarcinoma. We comparatively assessed intratumoral histologic stroma quantity, tumor immune cell infiltrate, and blood leukocyte and thrombocyte count in 72 patients stratified in 3 strata of biological age (younger <70 years, fit older ≥70 years, and frail older adults ≥70 years), as defined by a geriatric assessment. Frailty in older adults was predictive of decreased intratumoral stroma quantity (B = -14.66% stroma,P= 0.022) relative to tumors in chronological-age-matched fit older adults. Moreover, in comparison to younger adults, frail older adults (P= 0.032), but not fit older adults (P= 0.302), demonstrated a lower blood thrombocyte count at the time of diagnosis. Lastly, we found an increased proportion of tumors with a histologic desert TME phenotype in frail older adults. Our findings provide a biological underpinning for the clinical relevance of assessing frailty in patients with esophageal adenocarcinoma, further justifying the need for standardized geriatric assessment in geriatric cancer patients.

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“…Mortality is perhaps the most fundamental aspect of aging, but it also has the disadvantage of taking a long time to measure. A desire to more rapidly determine an individual's biological age (as opposed to their chronological age), and to gain deeper insight into the biological mechanisms of aging, has led to the development of dozens of biomarkers of aging 79 . These biomarkers, or aging clocks, run the gamut from phenotypic observations of traits such as grip strength and conventional medical blood tests to advanced (epi)genetic tests.…”

Section: Can We Succeed Where Gilgamesh Failed?mentioning

confidence: 99%