RANTES gene mRNA expression and its −403 G/A promoter polymorphism in coronary artery disease

Bazzaz, Javad Tavakkoly; Amiri, Parvin; Tajmir-Riahi, Mohammad; Javidi, Daryoosh; Khojasteh-Fard, Maryam; Taheri, Zahra; Tabrizi, A Sharif; Keramatipour, Mohammad; Amoli, Mahsa M.

doi:10.1016/j.gene.2011.07.019

Cited by 13 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diverse genotyping methods were used, including single-strand conformation polymorphism (SSCP), TaqMan, SNaPshot, restriction fragment length polymorphisms (RFLP), and polymerase chain reaction with sequence-specific primers (PCR-SSP). The definition of cases varied among studies, but most employed coronary angiography for diagnosis of CAD [9], [11]–[13], [17]. Five studies recruited population-based controls and three [9], [12], [13] recruited patients without CAD as controls.…”

Section: Resultsmentioning

confidence: 99%

RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies

Jia

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

ObjectiveThe G-403A polymorphism in RANTES gene may be involved in the development of coronary artery disease (CAD) through increasing RANTES-mediated leukocyte trafficking and activation. However, studies investigating the relationship between G-403A polymorphism and CAD yielded contradictory and inconclusive results. In order to shed some light on these inconsistent findings, a meta analysis was performed to clarify the role of G-403A polymorphism of RANTES gene in the susceptibility of CAD.MethodsA systemic literature search of PubMed and EMBASE was conducted from their inception to March 23, 2012, to retrieve related studies. In addition, Conference Proceedings Citation Index-Science was searched, authors of relevant studies were contacted, and reference lists of the included studies and their related citations in PubMed were reviewed for additional pertinent studies.ResultsA total of 8 eligible studies were identified, with a total of 4252 CAD cases and 2150 controls. There was no evidence of significant association between G-403A polymorphism and CAD risk in any genetic model or pairwise comparisons (additive model: OR = 1.046, 95% CI = 0.883–1.239, I2 = 65.9%; recessive model: OR = 1.140, 95% CI = 0.774–1.678, I2 = 53.1%; dominant model: OR = 1.000, 95% CI = 0.820–1.21), I2 = 62.6%; AA vs GG: OR = 1.141, 95% CI = 0.734–1.773, I2 = 61.2%; GA vs GG: OR = 0.993, 95% CI = 0.800–1.232, I2 = 64.6%). Subgroup analysis and meta regression indicated that ethnicity and genotyping method accounted for the significant heterogeneity among studies. In the stratified analysis by ethnic group, G-403A polymorphism was found to be associated with increased CAD risk in Caucasian population whereas its protective role was observed in Asian population in some but not all comparisons.ConclusionData from the current meta-analysis do not support the existence of a relationship between G-403A polymorphism and the development of CAD, and large sample size study employing unified genotyping method is needed to further evaluate the influence of G-403A polymorphism on susceptibility of CAD.

show abstract

Section: Resultsmentioning

confidence: 99%

RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies

Jia

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In a study of Iranian population, no significant difference in allele and genotype frequencies of RANtES−403 polymorphism was observed between coronary atherosclerosis (CAD) patients and healthy controls [11]. In current Table 2 Male 0 (0) 0 (0) 25 (100) a study we have found a significant difference for distribution of genotype AA+gA between males MD patients compared to the controls indicating a gender specific role for RANtES−403A allele in MD.…”

Section: Discussionmentioning

confidence: 50%

“…RANtES gene encodes a 8 KD protein which is a subfamily of chemotactic cytokines [4] and it codes for a chemotactic protein attracting inflammatory cells such as memory t cells (CD4+, CD45RO+), stimulated t cells (CD8+, CD4+), natural killer cells [5], basophils, eosinophils [6], dendritic cells, mast cells [7], monocytes [8], and microglia [9]. RANtES gene expression has been determined in many inflammatory diseases [10,11]. Several studies have suggested an association between −403g>A polymorphism in the promoter region of RANtES gene with some inflammatory disease such as asthma, sarcoidosis and atherosclerosis [12].…”

Section: Introductionmentioning

confidence: 99%

Sex-specific association of RANTES gene −403 variant in Meniere’s disease

Yazdani

Mojbafan

Taleba

et al. 2014

Eur Arch Otorhinolaryngol

Self Cite

View full text Add to dashboard Cite

Several studies have shown the correlation between RANTES gene and inflammatory disorders; the aim of the present study was to investigate the association between RANTES promoter gene polymorphism and Meniere's disease (MD) in an Iranian population. In this study patients with MD comprising definite MD (N = 56) and probable MD (N = 15) were selected according to diagnostic criteria of AAO-HNS. The control group (N = 101) were healthy normal subjects who did not have a history of ear disease and vertigo. PCR-RFLP for RANTES -403G>A has been performed. We found a protective role for RANTES -403A allele in male group in our population. None of the male patients with MD were carrier of allele A which was significantly different from the presence of allele A in the male control group (AA+GA vs. GG: p = 0.0004, OR 0.05, 95 % CI 0.001-0.39). This difference was not significant in female group. There was no significant association between RANTES gene polymorphism and the level of hearing loss. our results showed a sex-specific association between RANTES gene polymorphism and MD but more studies are necessary to further assess this association.

show abstract

“…By contrast, Jang et al (2007) have suggested that the -403A allele was associated with lower serum RANTES concentration and described the significant protective effect of the polymorphism on CAD risk in Korean male patients with or without type 2 diabetes (Jang et al, 2007). Most of the studies in this meta-analysis showed no relationship between the polymorphism and CAD risk (Szalai et al, 2001;Park et al, 2007;Vogiatzi et al, 2009;Shi Ying et al, 2010;Tavakkoly-Bazzaz, et al, 2011;Tereshchenko et al, 2011).…”

Section: Discussionmentioning

confidence: 75%

“…RANTES (regulation on activation normal T cell expressed and secreted), also known as C-C ligand 5, belongs to the CC chemokine family (Appay et al, 2001), and its expression has been detected in T cells in atherosclerotic plaques as well as in macrophages, endothelial cells, lymphocytes, and vascular smooth muscle cells, suggesting its role in the development and progression of AS (Szalai et al, 2001;Tavakkoly-Bazzaz et al, 2011). RANTES is coded by the RANTES gene, which is localized to the region q11.2-q12 of chromosome 17.…”

Section: Introductionmentioning

confidence: 99%

Association of the G403A polymorphism in the RANTES gene with coronary artery disease: a meta-analysis

Cui¹,

Ge²,

L³

2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The G403A polymorphism in the RANTES (regulated on activation normal T cell expressed and secreted) gene has a key role in the expression of RANTES, which has been detected in a range of cells in atherosclerotic plaque. However, the association of this polymorphism with the risk of coronary artery disease (CAD) remains controversial. A meta-analysis was performed to assess the association of the G403A polymorphism in the RANTES gene with the risk of CAD. A comprehensive search was conducted to identify all studies published on the association of the RANTES gene G403A polymorphism with CAD risk. The fixed or random-effect pooled measure was adopted based on a heterogeneity test among studies, which was evaluated using I 2 . Potential sources of between-study heterogeneity were explored using meta-regression analysis. Publication bias was estimated with Begg's rank correlation method. Eight articles were included in this meta-analysis, with 4601 CAD cases and 2522 controls. No significant association of RANTES gene G403A polymorphism with CAD was identified in any of the codominant, dominant, recessive, homozygote, or heterozygote inheritance models. No evidence of publication bias 3913 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (3): 3912-3918 (2013) RANTES gene polymorphism and coronary artery disease was detected. The meta-analysis suggested that the A allele of the G403A polymorphism in the RANTES gene has no effect on the risk of CAD. This relationship needs to be confirmed by further studies.

show abstract

RANTES gene mRNA expression and its −403 G/A promoter polymorphism in coronary artery disease

Cited by 13 publications

References 23 publications

RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies

RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies

Sex-specific association of RANTES gene −403 variant in Meniere’s disease

Association of the G403A polymorphism in the RANTES gene with coronary artery disease: a meta-analysis

Contact Info

Product

Resources

About