Rapid and Continuous Hydrodynamically Controlled Fabrication of Biohybrid Microfibers

Daniele, Michael A.; North, Stella H.; Naciri, Jawad; Howell, Peter B.; Foulger, Stephen H.; Ligler, Frances S.; Adams, André A.

doi:10.1002/adfm.201202258

Cited by 54 publications

(67 citation statements)

References 38 publications

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“…Such a technique provides excellent manipulation on microflow jets, 17, [29][30][40][41][42] showing great potential for manufacturing microfibers with controllable separated external or internal knots. 17, [43][44][45][46][47] By using a microfluidic chip combined with a digital fluid controller and pneumatic valves, spider-silk-like calcium alginate (CaAlg) microfibers with controllable external spindle-knots are developed from jet templates for water collection.…”

mentioning

confidence: 99%

“…[27][28][29][30][31][32][33][34][35][36][37] Typically, microfibers with separated spindleknots can be achieved by dip-coating of commercial microfibers into polymer solutions. 1,20,38 Thus, polymer solution drops can form along the microfiber due to the Rayleigh instability, and then spindle-knots are generated after evaporating the solvent of the polymer solution drops.…”

mentioning

confidence: 99%

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Microfluidic Fabrication of Bio-Inspired Microfibers with Controllable Magnetic Spindle-Knots for 3D Assembly and Water Collection

Wang

Liu

et al. 2015

ACS Appl. Mater. Interfaces

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A simple and flexible approach is developed for controllable fabrication of spider-silk-like microfibers with tunable magnetic spindle-knots from biocompatible calcium alginate for controlled 3D assembly and water collection. Liquid jet templates with volatile oil drops containing magnetic Fe3O4 nanoparticles are generated from microfluidics for fabricating spider-silk-like microfibers. The structure of jet templates can be precisely adjusted by simply changing the flow rates to tailor the structures of the resultant spider-silk-like microfibers. The microfibers can be well manipulated by external magnetic fields for controllably moving, and patterning and assembling into different 2D and 3D structures. Moreover, the dehydrated spider-silk-like microfibers, with magnetic spindle-knots for collecting water drops, can be controllably assembled into spider-web-like structures for excellent water collection. These spider-silk-like microfibers are promising as functional building blocks for engineering complex 3D scaffolds for water collection, cell culture, and tissue engineering.

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confidence: 99%

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confidence: 99%

Microfluidic Fabrication of Bio-Inspired Microfibers with Controllable Magnetic Spindle-Knots for 3D Assembly and Water Collection

Wang

Liu

et al. 2015

ACS Appl. Mater. Interfaces

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“…This morphology in turns affect the physical features like coefficient of friction , rigidity, lustre, color, and wicking properties. Such fibers are also being considered for applications in tissue engineering (Daniele et al (2013); Polini et al (2010)). …”

Section: Introductionmentioning

confidence: 99%

Morphology control in polymer blend fibers—a high throughput computing approach

Pokuri¹,

Ganapathysubramanian²

2016

Modelling Simul. Mater. Sci. Eng.

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Fibers made from polymer blends have conventionally enjoyed wide use, particularly in textiles. This wide applicability is primarily aided by the ease of manufacturing such fibers. More recently, the ability to tailor the internal morphology of polymer blend fibers by carefully designing processing conditions has enabled such fibers to be used in technologically relevant applications. Some examples include anisotropic insulating properties for heat and anisotropic wicking of moisture, coaxial morphologies for optical applications as well as fibers with high internal surface area for filtration and catalysis applications. However, identifying the appropriate processing conditions from the large space of possibilities using conventional trialand-error approaches is a tedious and resource-intensive process. Here, we illustrate a high throughput computational approach to rapidly explore and characterize how processing conditions (specifically blend ratio and evaporation rates) affect the internal morphology of polymer blends during solvent based fabrication. We focus on a P S : P M M A system and identify two distinct classes of morphologies formed due to variations in the processing conditions. We subsequently map the processing conditions to the morphology class, thus constructing a "phase diagram" that enables rapid identification of processing parameters for specific morphology class. We finally demonstrate the potential for time dependant processing conditions to get desired features of the morphology. This opens up the possibility of rational stage-wise design of processing pathways for tailored fiber morphology using high throughput computing.a) Corresponding

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“…12. Cells can be incorporated in biocompatible hydrogel prepolymers and survive the fabrication process with high viability 22 .…”

Section: Introductionmentioning

confidence: 99%

“…NRL investigators have demonstrated the following critical technical features [13][14][15][16][17][18][19][20][21] :…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Boyd

Adams

Daniele

et al. 2014

JoVE

Self Cite

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A "sheath" fluid passing through a microfluidic channel at low Reynolds number can be directed around another "core" stream and used to dictate the shape as well as the diameter of a core stream. Grooves in the top and bottom of a microfluidic channel were designed to direct the sheath fluid and shape the core fluid. By matching the viscosity and hydrophilicity of the sheath and core fluids, the interfacial effects are minimized and complex fluid shapes can be formed. Controlling the relative flow rates of the sheath and core fluids determines the crosssectional area of the core fluid. Fibers have been produced with sizes ranging from 300 nm to ~1 mm, and fiber cross-sections can be round, flat, square, or complex as in the case with double anchor fibers. Polymerization of the core fluid downstream from the shaping region solidifies the fibers. Photoinitiated click chemistries are well suited for rapid polymerization of the core fluid by irradiation with ultraviolet light. Fibers with a wide variety of shapes have been produced from a list of polymers including liquid crystals, poly(methylmethacrylate), thiol-ene and thiol-yne resins, polyethylene glycol, and hydrogel derivatives. Minimal shear during the shaping process and mild polymerization conditions also makes the fabrication process well suited for encapsulation of cells and other biological components.

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Rapid and Continuous Hydrodynamically Controlled Fabrication of Biohybrid Microfibers

Cited by 54 publications

References 38 publications

Microfluidic Fabrication of Bio-Inspired Microfibers with Controllable Magnetic Spindle-Knots for 3D Assembly and Water Collection

Microfluidic Fabrication of Bio-Inspired Microfibers with Controllable Magnetic Spindle-Knots for 3D Assembly and Water Collection

Morphology control in polymer blend fibers—a high throughput computing approach

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

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