Rapid and sensitive method for the determination of sertraline in human plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS)

Analysis of second-generation antidepressant drug, sertraline and its active metabolite, N-desmethyl sertraline in human plasma by a sensitive and selective liquid chromatography–tandem mass spectrometry method

“…SER as a single analyte has been determined with high sensitivity (0.1-0.5 ng/mL) in human plasma by GC-MS [7] and LC-MS/MS [8][9][10] methods. Several methods for the simultaneous determination of SER along with other antihypertensive drugs are presented using capillary electrophoresis [11], GC-MS [12][13][14][15][16], HPLC with fluorescence [17], diode array [18,19] and UV detection [20][21][22][23][24][25][26] and LC-MS/MS [27][28][29][30].…”

In-tube solid-phase microextraction coupled to liquid chromatography (in-tube SPME/LC) analysis of nontricyclic antidepressants in human plasma

“…Mirtazapine is the only antidepressant that increases noradrenergic and serotonergic neurotransmission through a blockade of central ␣2-adrenergic auto-and hetero-receptors. Duloxetine is a dual inhibitor of norepinephrine and serotonin uptake; it is a less potent inhibitor of dopamine reuptake [1,2]. The chemical structures of these antidepressants are shown in Depression is diagnosed on the basis of abnormal positive effects (anhedonia) and negative effects (low mood, helplessness, coping deficit, fatigue), and associated physiological abnormalities include hyperactivity of the hypothalamicpituitary-adrenal (HPA) endocrine system and autonomic nervous system.…”

Rapid analysis of sertraline, fluvoxamine, and paroxetine in serum specimens by LC-MS-MS using a new polymer column

“…Although there are a number of reports [9][10][11][12][13][14][15][16][17][18] dealing with detection of SSRI drugs by LC-MS-MS, the present combination with the new polymer column has never been reported. The column provides function for both drug extraction and LC separation; crude serum or plasma samples can be injected without any complicated pretreatment.…”

“…However, a death due to overdose of citalopram, one of the SSRI drugs, was reported in 2005 [2]. SSRI drugs have been analyzed by gas chromatography-mass spectrometry (GC-MS) with derivatization [3], high-performance liquid chromatography [4,5], liquid chromatography (LC)-MS [6][7][8], and LC-MS-MS [9][10][11][12][13][14][15][16][17][18]. In this study, we combined an LC-MS-MS instrument with a new polymer column, which enables direct injection of crude biological samples without complicated pretreatments and without a column switching system.…”