2017
DOI: 10.1002/rcm.7926
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Rapid and simple flow injection analysis tandem mass spectrometric method for the quantification of melphalan in a lipid‐based drug delivery system

Abstract: Rationale: The use of the anticancer drug melphalan is limited due to its poor water solubility.To address this limitation, it is incorporated within a novel delivery system using β-cyclodextringemini surfactants (18:1βCDg).Methods: Herein, two fast and simple flow injection analysis/tandem mass spectrometric (FIA-MS/MS) methods are developed for the quantification of melphalan (Mel) within the drug delivery system so that the solubilization efficiency of the system can be assessed. FIA-MS/MS methods are devel… Show more

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Cited by 5 publications
(4 citation statements)
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“…In the present study, the “cooperative interaction” only occurred when Mel was added to the 18:1βCDg. The foregoing solubility results inferred from the 2D NMR results agree with the CIS data herein (Table 1) and with solubility evaluation results reported previously using mass spectrometry [41]. The 1 H NMR CIS data in Table 1 provide evidence of destabilization of the carrier–drug inclusion complex due to hydrophobic effects and conformational motility of the 18:1βCDg at higher carrier loading, as indicated by the downfield shifts of the βCD extracavity (or framework) nuclei (i.e., H 1 , H 6 , and H 4 ).…”
Section: Resultssupporting
confidence: 90%
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“…In the present study, the “cooperative interaction” only occurred when Mel was added to the 18:1βCDg. The foregoing solubility results inferred from the 2D NMR results agree with the CIS data herein (Table 1) and with solubility evaluation results reported previously using mass spectrometry [41]. The 1 H NMR CIS data in Table 1 provide evidence of destabilization of the carrier–drug inclusion complex due to hydrophobic effects and conformational motility of the 18:1βCDg at higher carrier loading, as indicated by the downfield shifts of the βCD extracavity (or framework) nuclei (i.e., H 1 , H 6 , and H 4 ).…”
Section: Resultssupporting
confidence: 90%
“…The phase-solubility relationship describes only the solubilizing effect of the CD on the drug molecule but not the actual formation of inclusion complexes. Based on the phase-solubility diagram of Higuchi and Connors, the solubility evaluation results reported previously using flow-injection mass spectrometry of 18:1βCDg-Mel [41] and the NMR results discussed herein, we propose that the relationship between the solubility of Mel and the concentration of the host (18:1βCDg) follows either A N or A-B S -type model. A N -type model indicates the formation of a host–drug soluble complex with negatively deviating isotherms, whereas the A-B S -type indicates the formation of a complex with limited solubility [43].…”
Section: Resultsmentioning
confidence: 68%
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“…loop injection) has emerged as an effective approach that offers a rapid sample possessing rate, low cost, and method simplicity [31]. It has been successfully applied in the quantitation of several analytes, including pharmaceuticals, environmental contaminants, and endogenous compounds [32,33]. Therefore, FIA-MS/MS methods were developed removing the need for chromatographic separation while relying on the MS separation capabilities.…”
Section: Methods Developmentmentioning
confidence: 99%