Rapid custom prototyping of soft poroelastic biosensor for simultaneous epicardial recording and imaging

Abstract

The growing need for the implementation of stretchable biosensors in the body has driven rapid prototyping schemes through the direct ink writing of multidimensional functional architectures. Recent approaches employ biocompatible inks that are dispensable through an automated nozzle injection system. However, their application in medical practices remains challenged in reliable recording due to their viscoelastic nature that yields mechanical and electrical hysteresis under periodic large strains. Herein, we report sponge-like poroelastic silicone composites adaptable for high-precision direct writing of custom-designed stretchable biosensors, which are soft and insensitive to strains. Their unique structural properties yield a robust coupling to living tissues, enabling high-fidelity recording of spatiotemporal electrophysiological activity and real-time ultrasound imaging for visual feedback. In vivo evaluations of custom-fit biosensors in a murine acute myocardial infarction model demonstrate a potential clinical utility in the simultaneous intraoperative recording and imaging on the epicardium, which may guide definitive surgical treatments.

Approaching intrinsic dynamics of MXenes hybrid hydrogel for 3D printed multimodal intelligent devices with ultrahigh superelasticity and temperature sensitivity

“…However, the ambiguity in the response mechanism of MXenes based hydrogel sensors inhibits the deep understanding and further employment of multicomponent polymer hydrogel composites 28 – 30 . Moreover, the fabrication method, processing cost of sensors and multi-functionalization of flexible sensing integration systems remain challenging fields, which further impede the development of specific application scenarios as well 31 , 32 .…”

Recent Advances in 3D Printing of Biomedical Sensing Devices

“…[ 64 ] An implanted soft biosensor was fabricated using DIW for simultaneous epicardial recording of electrocardiography (ECG) signals from the murine heart as shown in Figure 3d. [ 65 ] In addition, the capability of introducing multiple printheads and even printhead array in DIW enables the one‐step high‐speed multi‐material fabrication, which further enhances the possibility of mass production of highly customized biomedical devices. [ 66,67 ] Being inspired by this µm‐resolution printing technique, several devices such as 3D periodic structures, [ 68 ] 3D microvascular networks, [ 69 ] photonic structures [ 70 ] with 3D metal electrodes, [ 71 ] and drug‐delivery devices [ 72 ] have been demonstrated.…”

“…c) Schematic representation of direct ink write (DIW) 3D printer. [ 65 ] d) A picture of implanted soft biosensor used for simultaneous epicardial recording of ECG signal from murine. [ 65 ] e) SLA‐based 3D printing wherein the manufacture of a microfluidic device is taken for demonstration.…”

“…[ 65 ] d) A picture of implanted soft biosensor used for simultaneous epicardial recording of ECG signal from murine. [ 65 ] e) SLA‐based 3D printing wherein the manufacture of a microfluidic device is taken for demonstration. [ 23 ] f) Set up of a two photon polarization (2PP) with associated optical circuitry.…”

A novel biomimetic nanomedicine system with anti-inflammatory and anti-osteoporosis effects improves the therapy efficacy of steroid-resistant nephrotic syndrome

“…As a powerful driver in biomedical development, nanotechnology has shown great promise in the fields of early diagnosis, treatment, prevention of disease and bioengineering [ 21 – 23 ]. Nanomaterials loaded with traditional drugs can reduce the dosage of drugs and lead to targeted slow release [ 24 ].…”