Recent Advances in 3D Printing of Biomedical Sensing Devices

Ali, Md. Azahar; Hu, Chunshan; Yttri, Eric A.; Panat, Rahul

doi:10.1002/adfm.202107671

Cited by 78 publications

(57 citation statements)

References 212 publications

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“…There are multiple implications of this work. First, like recent work using additive manufacturing [28], this HDCF array assembly machine demonstrates another alternative to traditional silicon array fabrication. While this work utilized CF, it could likely be extended to fabrication in other geometries and with other electrode materials not amenable to lithography such as tungsten.…”

Section: Discussionmentioning

confidence: 93%

Automated assembly of high-density carbon fiber electrode arrays for single unit electrophysiological recordings

Dong

Chen

Patel

et al. 2022

Preprint

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Objective: Carbon fiber (CF) is good for chronic neural recording due to the small diameter (7 μm), high Young's modulus, and low electrical resistance, but most high-density carbon fiber (HDCF) arrays are manually assembled with labor-intensive procedures and limited by the accuracy and repeatability of the operator handling. A machine to automate the assembly is desired. Approach: The HDCF array assembly machine contains: 1) a roller-based CF extruder, 2) a motion system with three linear and one rotary stages, 3) an imaging system with two digital microscope cameras, and 4) a laser cutter. The roller-based extruder automatically feeds single CF as raw material. The motion system aligns the CF with the array backend then places it. The imaging system observes the relative position between the CF and the backend. The laser cutter cuts off the CF. Two image processing algorithms are implemented to align the CF with the support shanks and circuit connection pads. Main results: The machine was capable of precisely handling 6.8 μm carbon fiber electrodes. Each electrode was placed into a 12 μm wide trenches in a silicon support shank. Two HDCF arrays with 16 CF electrodes populated on 3 mm shanks (with 80 μm pitch) were fully assembled. Impedance measurements were found to be in good agreement with manual assembled arrays. One HDCF array was implanted in the motor cortex in an anesthetized rat and was able to detect single unit activity. Significance: This machine can eliminate the manual labor-intensive handling, alignment and placement of single carbon fiber during assembly, providing a proof-of-concepts towards fully automated HDCF array assembly and batch production.

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Section: Discussionmentioning

confidence: 93%

Automated assembly of high-density carbon fiber electrode arrays for single unit electrophysiological recordings

Dong

Chen

Patel

et al. 2022

Preprint

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“…Strong and portable products are required by the aircraft industry and healthcare industries. Matrix hybrid composites are attracting a lot of interest in today's society because they offer excellent mechanical and long-term durability, as well as other thermos electrical structures [124].…”

Section: Recent Advances In Manufacturingmentioning

confidence: 99%

3d Printing: A Review on the Transformation of Additive Manufacturing

KUMAR

SINGH

et al. 2022

Int J App Pharm

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3D printing and nanotechnology have been two of the most important tools in the development of personalized medical treatments. More recently, their alliance has developed in an effort to create new, flexible, multidisciplinary, and/or medical and drug-wise products. Therefore, a comprehensive review of scientific studies, including 3D printing and nanomaterials on the development of new pharmaceutical methods and medical applications for the treatment and prevention of diseases, is presented here with the help of secondary research from most recent articles. 3D printing, also known as additive manufacturing, has held the power of building a new class of active nanocomposites. With the ability to print a layer of complex 3D objects by layer, additional production of nanomaterials can be used in new ways to significantly control architectural structures of all sizes. The high efficiency of embedded nanomaterials can further extend the power of nanocomposites to structures such as gradients in thermal conductivity, converted photonic emissions, and increased energy and reduced weight. According to the survey done by annual industry, around 50% of the market of 3d printing in the industrial sectors is credited to created prototypes by means of photopolymers. While, Formlabs, Stratasys, HP, Desktop Metal, Ultimaker, Carbon, EOS, Nanoscribe and Markforged are among the top additive manufacturers. This work is hereby an effort to focus on different techniques, merits and demerits, applications, recent advances, relation with nanotechnology along with future aspects.

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“… 24 On the whole, 3D printing has revolutionized the manufacturing sector through its ability to create hierarchical complex architectures, controlled microstructures, and material combinations, 25 all of which have benefited the biosensor area. 26 , 27 …”

Section: Introductionmentioning

confidence: 99%

N protein‐based ultrasensitive SARS‐CoV‐2 antibody detection in seconds via 3D nanoprinted, microarchitected array electrodes

Ali

Zhang

et al. 2022

Journal of Medical Virology

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Rapid detection of antibodies to SARS-CoV-2 is critical for COVID-19 diagnostics, epidemiological research, and studies related to vaccine evaluation. It is known that the nucleocapsid (N) is the most abundant protein of SARS-CoV-2 and can serve as an excellent biomarker due to its strong immunogenicity. This paper reports a rapid and ultrasensitive 3D biosensor for quantification of COVID-19 antibodies in seconds via electrochemical transduction. This sensor consists of an array of threedimensional micro-length-scale electrode architecture that is fabricated by aerosol jet 3D printing, which is an additive manufacturing technique. The micropillar array is coated with N proteins via an intermediate layer of nano-graphene and is integrated into a microfluidic channel to complete an electrochemical cell that uses antibodyantigen interaction to detect the antibodies to the N protein. Due to the structural innovation in the electrode geometry, the sensing is achieved in seconds, and the sensor shows an excellent limit of detection of 13 fm and an optimal detection range of 100 fm to 1 nM. Furthermore, the sensor can be regenerated at least 10 times, which reduces the cost per test. This work provides a powerful platform for rapid screening of antibodies to SARS-CoV-2 after infection or vaccination.

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Recent Advances in 3D Printing of Biomedical Sensing Devices

Cited by 78 publications

References 212 publications

Automated assembly of high-density carbon fiber electrode arrays for single unit electrophysiological recordings

Automated assembly of high-density carbon fiber electrode arrays for single unit electrophysiological recordings

3d Printing: A Review on the Transformation of Additive Manufacturing

N protein‐based ultrasensitive SARS‐CoV‐2 antibody detection in seconds via 3D nanoprinted, microarchitected array electrodes

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