Rapid detection and quantification of paracetamol and its major metabolites using surface enhanced Raman scattering

Abstract

Paracetamol (also known as acetaminophen) is an over the counter (OTC) drug that is commonly used as an analgesic for mild pain, headache, cold and flu. While in the short...

Office paper and laser printing: a versatile and affordable approach for fabricating paper-based analytical devices with multimodal detection capabilities

“…The literature shows that the useful therapeutic concentration range of Par in plasma and serum samples is 2.5–25 μg mL −1 . 62 Paracetamol produces analgesia by altering serotonin-dependent neurotransmission in the central nervous system, resulting in altered peripheral pain mechanisms. However, doses higher than 70 μg mL −1 of paracetamol can cause acute hepatotoxicity by metabolizing a benzoquinone that is highly toxic to hepatocytes.…”

Lectin-conjugated nanotags with high SERS stability: selective probes for glycans

“…Aggregation-based SERS biosensors has been used for quantification of small analyte molecules in the solution. For example, AlMasoud et al 28 have quantified paracetamol by monitoring the SERS intensity of a mixture of AuNPs and target analyte. The presence of paracetamol led to aggregation of AuNPs, where SERS intensity of paracetamol was proportional to the concentration of paracetamol.…”

Analysis of friction ridge evidence for trace amounts of paracetamol in various pharmaceutical industries by Raman spectroscopy

“…Studies conducted to date using Raman spectroscopy have not focused on the influence of additives on the Raman scattering spectrum of paracetamol, nor have they analyzed in depth the background effect of the external environment. Studies by other authors primarily focused on the differentiation of paracetamol, ibuprofen, and other analgesics, representing a basic interpretation from the perspective of Raman analysis [18][19][20][21].…”