Rapid detection of antibiotic residues in animal products using surface-enhanced Raman Spectroscopy: A review

Girmatsion, Mogos; Mahmud, Abdu; Abraha, Bereket; Xie, Yunfei; Cheng, Yuliang; Yu, Hang; Yao, Weirong; Guo, Yahui; Qian, He

doi:10.1016/j.foodcont.2021.108019

Cited by 60 publications

(23 citation statements)

References 89 publications

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“…SERS has a strong application potential and high practical value in the field of food safety evaluation because of its technical advantages, such as fast detection, resistance to water interference, and its ability to provide fingerprint structure information of the target [119]. However, this method also has many limitations and deficiencies when applied in detecting complex sample matrices.…”

Section: Future Trendsmentioning

confidence: 99%

A Review of Detection of Antibiotic Residues in Food by Surface-Enhanced Raman Spectroscopy

Liang

Peng

et al. 2021

Bioinorganic Chemistry and Applications

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Antibiotics, as veterinary drugs, have made extremely important contributions to disease prevention and treatment in the animal breeding industry. However, the accumulation of antibiotics in animal food due to their overuse during animal feeding is a frequent occurrence, which in turn would cause serious harm to public health when they are consumed by humans. Antibiotic residues in food have become one of the central issues in global food safety. As a safety measure, rapid and effective analytical approaches for detecting these residues must be implemented to prevent contaminated products from reaching the consumers. Traditional analytical methods, such as liquid chromatography, liquid chromatography mass spectrometry, and capillary electrophoresis, involve time-consuming sample preparation and complicated operation and require expensive instrumentation. By comparison, surface-enhanced Raman spectroscopy (SERS) has excellent sensitivity and remarkably enhanced target recognition. Thus, SERS has become a promising alternative analytical method for detecting antibiotic residues, as it can provide an ultrasensitive fingerprint spectrum for the rapid and noninvasive detection of trace analytes. In this study, we comprehensively review the recent progress and advances that have been achieved in the use of SERS in antibiotic residue detection. We introduce and discuss the basic principles of SERS. We then present the prospects and challenges in the use of SERS in the detection of antibiotics in food. Finally, we summarize and discuss the current problems and future trends in the detection of antibiotics in food.

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Section: Future Trendsmentioning

confidence: 99%

A Review of Detection of Antibiotic Residues in Food by Surface-Enhanced Raman Spectroscopy

Liang

Peng

et al. 2021

Bioinorganic Chemistry and Applications

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“…The researchers compared the detection effect of this method and ultra-highperformance liquid chromatography-mass spectrometry (UHPL-LC/MS) on the same sample. The test results show that the data obtained by the two monitoring methods are similar, which proves that the time-resolved fluorescence immunoassay method can accurately detect streptomycin residues in milk [45].…”

Section: Immunoassaymentioning

confidence: 64%

“…Yuanze and Jie et al used TIME-RESOLVED FLUOROIMMUNOASSAY to quantify the residual streptomycin in milk. This method uses a europium (EU3+) chelate-labeled secondary antibody as a tracer, and trichloroacetic acid is used to deproteinize milk samples [45]. The results showed that the detection limit of streptomycin in milk was 1.8mG/KG, the sample recovery rate was 86.2-96.3%, and the relative standard deviation was less than 11%.…”

Section: Immunoassaymentioning

confidence: 99%

Hazards and Detection Techniques of Veterinary Drug Residues in Animal-Origin Food

Chen

2021

E3S Web Conf.

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Veterinary drugs originally used to diagnose, prevent, control and treat animal diseases. However, now some of them can also be mixed into livestock feed as growth promoters. Although most countries have specified animal-derived veterinary drug residue standards, such as the maximum residue limit, withdrawal period and prohibition of some veterinary drugs as growth promoters, there are still some animal-derived products with illegal amount of drug residues. Consequently, long-term intake of products with excessive residues will result in irreversible impacts on human health, livestock industries and natural environment. To minimize these risks, the techniques of drug residues detection plays an important role in guarding food safety of animal products. Moreover, Veterinary drug residue detection technology, according to the author's opinion, can be divided into instrumental method, immunoassay method, biomolecular technology and bio-sensor technology. The purpose of this article is to collect and summarize the existing journal literature current about status, hazards and detection techniques of animal-origin veterinary drug residues so that ordinary readers can briefly understand the research status of the residue detection techniques, farmers can understand the importance of regulating and suitable handling of veterinary drugs, and relevant researchers may know about the emphasized difficulties that need to be overcome in drug residue detection techniques.

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“…In addition, a selection of the most relevant developments is discussed in more detail herein. The development of SERS-based methods for antimicrobial detection and quantification initially began as a method to determine contaminants in food and the environment [47,48]; antibiotic detection in milk is one of the more commonly reported areas, due to contamination resulting from animals undergoing therapy. Although studies that provided data on real biofluids have been prioritized for this review, it should be noted that the goal of a simple and effective method for analyzing antibiotics in complex matrices, such as milk or honey, is analogous to TDM, and therefore, there is much to be gained in learning from the approaches pursued in those assays.…”

Section: Sers Applications For Tdm Of Antimicrobial Agentsmentioning

confidence: 99%

The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial Agents

2022

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The rapid quantification of antimicrobial agents is important for therapeutic drug monitoring (TDM), enabling personalized dosing schemes in critically ill patients. Highly sophisticated TDM technology is becoming available, but its implementation in hospitals is still limited. Among the various proposed techniques, surface-enhanced Raman scattering (SERS) stands out as one of the more interesting due to its extremely high sensitivity, rapidity, and fingerprinting capabilities. Here, we present a comprehensive review of various SERS-based novel approaches applied for direct and indirect detection and quantification of antibiotic, antifungal, and antituberculosis drugs in different matrices, particularly focusing on the challenges for successful exploitation of this technique in the development of assays for point-of-care tests.

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Rapid detection of antibiotic residues in animal products using surface-enhanced Raman Spectroscopy: A review

Cited by 60 publications

References 89 publications

A Review of Detection of Antibiotic Residues in Food by Surface-Enhanced Raman Spectroscopy

A Review of Detection of Antibiotic Residues in Food by Surface-Enhanced Raman Spectroscopy

Hazards and Detection Techniques of Veterinary Drug Residues in Animal-Origin Food

The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial Agents

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