Rapid detection of basic drugs in biological materials employing field desorption mass spectrometry

Goenechea, S.; Goebel, K. J.; Heinen, H. J.

doi:10.1007/bf00482274

Cited by 6 publications

(1 citation statement)

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“…In den letzten Jahren sind zur l.)berwindung dieser Probleme eine ganze Reihe verschiedener, allerdings experimentell aufwendiger, haupts~ichlich massenspektrometrischer Megteclmlken entwickelt worden, die jedoch oft nut bei ganz speziellen Fragestellungen eindeutige Ergebnisse liefern; stellvertretend sei bier nur die Feld-Desorptions-Massenspektrometrie (FD-MS) genannt [1][2][3][4].…”

Section: W Gielsdorf Und P Farrowunclassified

FAB (Fast Atom Bombardment)-Massenspektrometrie

Gielsdorf

Farrow²

1982

Z Rechtsmed

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The FAB (Fast Atom Bombardment)-mass spectrometric ionization technique, which has now been available for about 1 year, has been successfully employed in forensic toxicology. The mass spectral behaviour of some representative drug-glucuronides (Codeine, p-Nitrophenol and 2-Phenyl-1-propanol) were studied by positive- and negative-ion-FAB-MS. The presented promising results may be of some interest, not only for the analytical toxicologist.

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Section: W Gielsdorf Und P Farrowunclassified

FAB (Fast Atom Bombardment)-Massenspektrometrie

Gielsdorf

Farrow²

1982

Z Rechtsmed

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Negative ion field desorption mass spectrometry by clustering with anions

Zwinselman

Fokkens

Nibbering

et al. 1981

Biol. Mass Spectrom.

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It is shown that under field desorption conditions some less volatile or non‐volatile compounds such as oligosaccharides, sulphonic acids and fatty acids can be ionized below the threshold of field electron emission by clustering with anions. In all cases the sample, together with polyethylene oxide 4000, is dissolved in water. The source of the clustering anion is provided either by a small amount of a salt added to this solution (sugars) or by the compounds themselves (sulphonic and fatty acids). The solution is applied to unactivated and/or slightly activated 10 μm tungsten wire cathodes. Suitable clustering ions for the sugars appear to be [Cl]−, [NO3]− and to a lesser extent [Br]− and [I]−. Most of the sulphonic acids studied give rise to the formation of [Mn—H]− ions (n⩽5), but their potassium salts yield only unclustered sulphonate anions. However, the addition of a small amount of LiCl to the mixture of benzene sulphonic acid and polyethylene oxide 4000 promotes the formation of clustered anions, [(M—H)2Li]− being by far the most abundant if activated cathodes are used. This addition of some LiCl is essential in the case of fatty acids: without LiCl no anions may be desorbed at all from activated wires, but with the presence of LiCl both [M—H]− and the most abundant [(M—H)2Li]− anions are easily generated.

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Mass spectrometry

Jones¹

1984

Analytical Methods in Human Toxicology

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Rapid detection of basic drugs in biological materials employing field desorption mass spectrometry

Cited by 6 publications

References 2 publications

FAB (Fast Atom Bombardment)-Massenspektrometrie

FAB (Fast Atom Bombardment)-Massenspektrometrie

Negative ion field desorption mass spectrometry by clustering with anions

Mass spectrometry

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