Rapid detection of hydrazine in almost wholly water solution and in living cells with a new colorimetric and fluorescent turn-on probe

Abstract

Detection of hydrazine is of particular interest given its toxicity and high levels of use. In this paper, a new fluorescent probe was developed for rapid detection of hydrazine. This probe is chemically masked with a 2-fluoro-5-nitro-benzoic ester motif as a new reaction site for hydrazine. More importantly, unlike most hydrazine probes in the literature that need to use high levels of organic solvents, this probe displays a fast colorimetric and fluorescent turn-on response for hydrazine with high selectivity and sensitivity in almost wholly water solution under mild conditions. The detection limit of this probe for hydrazine is about 0.10 µM (~3 ppb) with a linear range of 0-20 µM. Further investigation showed that this probe could be used to develop an easy-to-prepare and easy-to-detect paper test strip for cheap and effective visual detection of hydrazine. In addition, this probe can be used to image hydrazine in living cells.

Covalent Organic Frameworks Doped with Different Ratios of OMe/OH as Fluorescent and Colorimetric Sensors

“…synthesized DQ‐COF with redox activity for detecting and removing hydrazine. In addition, methods to detect pH and N 2 H 4 also include indicator, [26] fluorescent probe, [27,28] carbon dot, [29] ion‐sensitive field effect transistor, [30] and ultraviolet spectrophotometry [31] . However, the use of COFs as fluorescence sensors to detect pH and N 2 H 4 is still rare.…”

A paper-based inkjet-printed PEDOT:PSS/ZnO sol-gel hydrazine sensor

“…Conventional analytical techniques are used for hydrazine detection, such as spectrophotometry, chromatography, or electrochemical methods [9][10][11]. However, most of the commercial tools are extremely complex and exhibit low precision, although the electrochemical method of hydrazine detection offers simplicity, low cost, and rapid processes [12]. In addition, electrochemical digital signal read-out platforms are more robust than spectrophotometric detection methods and the detection system is suitable for miniaturization.…”

Recent Developments in Fluorometric and Colorimetric Chemodosimeters Targeted towards Hydrazine Sensing: Present Success and Future Possibilities

“…Feng et al . reported a new sensing scheme for hydrazine, which was based on a nucleophilic substitution followed by addition‐elimination in aryl ester (Figure ).…”