Rapid determination of quetiapine in blood by gas chromatography–mass spectrometry. Application to post‐mortem cases

López‐Guarnido, Olga; Tabernero, María Jesús; Hernández, Antonio F.; Rodrigo, Lourdes Sánchez; Bermejo, Ana María

doi:10.1002/jat.2944

Cited by 16 publications

(12 citation statements)

References 32 publications

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“…It shows high sensitivity and has a wide concentration range that includes sub-therapeutic to toxic quetiapine blood levels. The developed method when compared to previously published methods shows similar or better validation results, such as similar [37] or lower LOQ values [6,18,21,32,33] and relative [21,33] or wider linearity range [6,18]. The reliability of the method was also certified by means of a validation study and its successful application for the toxicological investigation of 50 quetiapine-related fatal cases.…”

Section: Discussionmentioning

confidence: 67%

“…A SIM chromatogram of a spiked blood sample with quetiapine at the LOQ concentration (5.00 ng/mL) is shown in Figure 2. The calibration curves were linear (R 2 ≥ 0.991) within the range of 5.00-2000.0 ng/mL, which covers the respective therapeutic and toxic quetiapine levels [18,19]. The absolute recoveries for quetiapine were found to be higher than 81% in all QC levels.…”

Section: Methods Validationmentioning

confidence: 85%

“…Several methods have been already published for the determination of quetiapine in biological samples using LC [37][38][39][40][41] or GC methods [6,18,21,32,33,42,43]. The aim of this work was to investigate quetiapine-related lethal cases to assess the contribution of quetiapine to the cause of death.…”

Section: Discussionmentioning

confidence: 99%

“…Peak quetiapine levels are usually observed in blood within 1-2 h and the levels are dose-dependent with a linear relationship within the range of the clinical daily doses (up to 700 mg) [3,15]. The reported in the literature therapeutic blood quetiapine concentrations range from 20 to 600 ng/mL while concentrations higher than 1800 and 4000 ng/mL have been characterized as toxic and lethal, respectively [18,19]. It is known that quetiapine has an exceptionally wide therapeutic index.…”

Section: Introductionmentioning

confidence: 99%

“…At the request of European Medicines Agency, the EMCDDA undertook a data collection exercise with the early warning System Network to provide the information on quetiapine abuse, misuse and dependency at the national level [31]. During the past decades, quetiapine-related deaths have been reported in Europe, Australia, Canada, and the United States [6,14,18,21,[32][33][34]. In Greece, the number of deaths related to quetiapine was also increased during the past 3 years.…”

Section: Introductionmentioning

confidence: 99%

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A validated GC/MS method for the investigation of quetiapine-related deaths in Greece

Papoutsis¹,

Katselou²,

Nikolaou³

et al. 2017

Eur J Forensic Sci

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Objective: Quetiapine is an atypical antipsychotic drug that is used to treat the symptoms of schizophrenia and other psychiatric disorders. During the last years, quetiapine has also been associated with cases of misuse and abuse, and there are strong indications that it possesses an addictive potential. A suitable method is necessary for the toxicological investigation of such cases. Materials and Methods: A simple gas chromatographymass spectrometric method was developed, validated, and applied for the determination of quetiapine in biological fluids during the investigation of quetiapine-related cases. The sample preparation procedure includes solid-phase extraction and silylation using N-methyl-N-tert-butyldimethylsilyl-trifluoroacetamide with 1% tert-butyldimethylsilylchloride. Results: The limits of detection and quantification were 1.50 and 5.00 ng/mL, respectively. The calibration curves were linear up to 2000 ng/mL (R 2 ≥ 0.991) and absolute recovery higher than 81%. Accuracy (intra-and inter-day) was found to be between −11.1 and 12.4%, whereas the precision was found to be <13.3%. The validated method was successfully applied to post-mortem blood samples during the toxicological investigation of 50 quetiapine-related sudden and violent deaths. Quetiapine was determined at toxic levels (>1800 ng/mL) in eight cases and at lower concentrations (5.21-1430 ng/mL) in the other 42 cases. It is remarkable to be mentioned that in all 50 cases one or more drugs were detected along with quetiapine. Conclusions: Quetiapine has been detected with increasing frequency in post-mortem cases in Greece during the last 3 years. This is in accordance with the growing concerns worldwide about the misuse or abuse of the drug and its contribution to the cause of death of quetiapine-related lethal cases. Physicians should be alert about the toxicity of quetiapine, its possible misuse or abuse, and its synergy with other drugs, medicinal or not, especially in patients under multiple drug therapy or drug addicts.

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Section: Discussionmentioning

confidence: 67%

Section: Methods Validationmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A validated GC/MS method for the investigation of quetiapine-related deaths in Greece

Papoutsis¹,

Katselou²,

Nikolaou³

et al. 2017

Eur J Forensic Sci

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Electrochemical Analysis of Antipsychotic Drug Quetiapine Fumarate Using Multi‐walled Carbon Nanotube Modified Glassy Carbon Electrode

2022

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Electrochemical properties of quetiapine fumarate were examined on the anodic direction with multi‐walled carbon nanotube modified glassy carbon electrode using voltammetric methods. The ratio of multi‐walled carbon nanotube has been optimized using its various concentrations. The oxidation process was found to be irreversible, and adsorption controlled. The linear ranges were determined as 4×10−9–2×10−6 M for differential pulse stripping voltammetry and 2×10−9–2×10−6 M for square‐wave stripping voltammetry with detection limits of 8.07×10−10 and 2.71×10−10 M, respectively. The methods were validated and successfully applied for the analysis of quetiapine fumarate tablets. The groups responsible for the oxidation reaction of quetiapine fumarate were investigated with model substances.

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Development and validation of a gas chromatography/tandem mass spectrometry method for simultaneous quantitation of several antipsychotics in human plasma and oral fluid

Rosado

Oppolzer

Cruz

et al. 2018

Rapid Comm Mass Spectrometry

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The described method was proven selective and sensitive for the determination of antipsychotics in low sample volumes using SPE and GC/MS/MS. This method was considered suitable not only for routine analysis of patients undergoing antipsychotic treatment (to evaluate compliance), but also in forensic scenarios where the studied compounds may be involved. To the best of our knowledge, this is the first work that reports the determination of antipsychotic drugs in oral fluid using MS/MS.

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Rapid determination of quetiapine in blood by gas chromatography–mass spectrometry. Application to post‐mortem cases

Cited by 16 publications

References 32 publications

A validated GC/MS method for the investigation of quetiapine-related deaths in Greece

A validated GC/MS method for the investigation of quetiapine-related deaths in Greece

Electrochemical Analysis of Antipsychotic Drug Quetiapine Fumarate Using Multi‐walled Carbon Nanotube Modified Glassy Carbon Electrode

Development and validation of a gas chromatography/tandem mass spectrometry method for simultaneous quantitation of several antipsychotics in human plasma and oral fluid

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