Rapid determination of the identity of aqueous drug solutions

Ulyantsev, A. S.; Uspenskaya, E. V.; Pleteneva, T. V.; Popov, P. I.; Samsoni-Todorov, A. O.; Гончарук, В. В.; Сыроешкин, А. В.

doi:10.1007/s11094-010-0381-1

Cited by 2 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the pharmaceutical industry, various approaches are used to increase the solubility of APIs: micronization, modification of the crystal structure, salt formation, preparation of solid dispersions, self-nanoemulsifying drug delivery system, mechanochemical synthesis and others [28][29][30]. In recent studies it was found that the physicochemical and biological properties of AРI aqueous solutions -the mutarotation rates, the angle of optical rotation, the lifetime of the cell biosensor are dependent on the D/H ratios [31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Role of stable hydrogen isotope variations in water for drug dissolution managing

Uspenskaya

Pleteneva

Сыроешкин

et al. 2020

Current Issues in Pharmacy and Medical Sciences

View full text Add to dashboard Cite

AbstractIn the present work, we provide the results of defining by utilizing Laser diffraction spectroscopy, the kinetic isotopic effect of solvent and constant of dissolution rate κ, s−1 of аn active pharmaceutical ingredient (API) in water with a different content of a stable _2^1{\rm{H}} isotope on the basis of the laws of first-order kinetics. This approach is based on the analysis of the light scattering profile that occurs when the particles of the dispersion phase in the aquatic environment are covered with a collimated laser beam. For the first time, the dependence of the rate of dissolution is demonstrated not only on the properties of the pharmaceutical substance itself (water solubility mg/ml, octanol–water partition coefficient log P oct/water, topological polar surface area, Abraham solvation parameters, the lattice type), but also on the properties of the solvent, depending on the content of stable hydrogen isotope. We show that the rate constant of dissolution of a sparingly hydrophobic substance moxifloxacin hydrochloride (MF · HCl) in the Mili-Q water is: k=1.20±0.14∙10−2 s−1 at 293.15 K, while in deuterium depleted water, it is k=4.24±0.4∙10−2 s−1. Consequently, we have established the development of the normal kinetic isotopic effect (kH/kD >1) of the solvent. This effect can be explained both by the positions of the difference in the vibrational energy of zero levels in the initial and transition states, and from the position of water clusters giving volumetric effects of salvation, depending on the ratio D/H. The study of kinetic isotopic effects is a method that gives an indication of the mechanism of reactions and the nature of the transition state. The effect of increasing the dissolution of the API, as a function of the D/H ratio, we have discovered, can be used in the chemical and pharmaceutical industries in the study of API properties and in the drug production through improvement in soluble and pharmacokinetic characteristics.

show abstract

Section: Introductionmentioning

confidence: 99%

Role of stable hydrogen isotope variations in water for drug dissolution managing

Uspenskaya

Pleteneva

Сыроешкин

et al. 2020

Current Issues in Pharmacy and Medical Sciences

View full text Add to dashboard Cite

show abstract

“…The method has successfully proven itself in assessing the quality of liquid dosage forms: suspensions, emulsions, tinctures, and determining the authenticity of medicinal and table waters without opening the package, as well as the stability of cluster structures in waters of different isotopic composition (Bunkin et al, 2018;Goncharuk et al, 2011;Karpov et al, 2011;Koldina et al, 2019;Ul'yantsev et al, 2009). Reliability of measurements, nondestructive nature, low cost, simplicity of calibration procedures, and short measurement times are important advantages of the method in the analysis of pharmaceutical substances.…”

Section: Introductionmentioning

confidence: 99%