Rapid determination of X-ray contrast agent iomeprol in human plasma by on-line solid-phase extraction coupled with phase optimized liquid chromatography

Zhou, Tingting; Tao, Ye; Pu, Yabing; Morello, Rosa; Mei, Surong; Boos, Karl-Siegfried

doi:10.1016/j.jchromb.2015.04.006

Search citation statements

Order By: Relevance

Paper Sections

Select...

Approaches To Selectivity Optimization1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Isocratic separations are more robust and methods can be transferred more easily. Commonly, the baseline is more stable and the re‐equilibrium time is shortened [44].…”

Section: Approaches To Selectivity Optimizationmentioning

confidence: 99%

Selectivity optimization in liquid chromatography via stationary phase tuning

Jaekel,

Legelli,

Wirtz

et al. 2023

J of Separation Science

View full text Add to dashboard Cite

In striving for the best possible separation, the selectivity of stationary phases as an optimization parameter is often underestimated although there are many ways to influence this powerful tool. This review serves to provide an insight into the various ways of adapting the selectivity of a separation in liquid chromatography. Approaches via temperature and flow rate tuning are discussed as a basis followed by focusing on the stationary phase as the superior optimization parameter. Highly selective stationary phases hereby provide an advantage for groups of similar analytes. For more complex mixtures, separations can be improved using mixed‐mode technologies where different retention mechanisms are combined. Serial coupling, mixed‐bed columns, and stationary phase optimized selectivity liquid chromatography provide solutions to various degrees. Finally, the advantages of stationary phase tuning over adaption of mobile phase and/or temperature are presented in terms of optimum application range.

show abstract

“…Isocratic separations are more robust and methods can be transferred more easily. Commonly, the baseline is more stable and the re‐equilibrium time is shortened [44].…”

Section: Approaches To Selectivity Optimizationmentioning

confidence: 99%