2020
DOI: 10.1002/pca.2902
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Rapid discrimination of Notopterygium incisum and Notopterygium franchetii based on characteristic compound profiles detected by UHPLC‐QTOF‐MS/MS coupled with multivariate analysis

Abstract: Introduction The herbs Notopterygium incisum (NI) and N. franchetii (NF) are referred to as “Qianghuo” in the Chinese Pharmacopeia and are popular for treatment of certain conditions, including headaches, rheumatoid arthritis and the common cold. Recently, several adulterations of NI and NF have been found in the Chinese herbal market. Objective The aim of this study was to rapidly identify the unique characteristic compounds of NI and NF, to discriminate Qianghuo from its adulterations. Methodology Twenty‐fou… Show more

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Cited by 18 publications
(5 citation statements)
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“…Multivariate analysis, including PCA and OPLS-DA, was performed on mass spectral data sets using SIMCA-P14.1 software. The loading plot from OPLS-DA together with the variable importance in the projection (VIP) were applied to reveal potential markers [ 14 , 15 , 16 ]. Thus, it is necessary to use multivariate analysis to reduce the dimensionality of the primal data.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Multivariate analysis, including PCA and OPLS-DA, was performed on mass spectral data sets using SIMCA-P14.1 software. The loading plot from OPLS-DA together with the variable importance in the projection (VIP) were applied to reveal potential markers [ 14 , 15 , 16 ]. Thus, it is necessary to use multivariate analysis to reduce the dimensionality of the primal data.…”
Section: Resultsmentioning
confidence: 99%
“…Ultra-high performance liquid chromatography coupled with the quadrupole time of flight mass spectrometry (UHPLC-QTOF-MS/MS) has been widely used in the separation and structural analysis of complex systems, such as traditional Chinese medicines, due to its rapid separation, high efficiency, high sensitivity, high resolution, and molecular weight accuracy [ 12 ]. It can be widely used for the chemical identification of different base sources and different medicinal parts of herbal medicines [ 13 , 14 , 15 ]. Recently, UHPLC-Q-Exactive Orbitrap MS, with a high selectivity and effectivity, was widely used in the identification of chemical constitutions…”
Section: Introductionmentioning
confidence: 99%
“…The next step involves aligning the features using an internal standard. Finally, for baseline correction, all compounds were treated with the calculated representative value ( Ma et al, 2020 ). The final data with accurate quality and retention time determined in FSG and PSG were imported into SIMCA-P to select specific biomarkers using PCA and OPLS-DA.…”
Section: Methodsmentioning
confidence: 99%
“…The analysis was conducted based on previous methods with some modifications. 15 A Waters Acquity UHPLC™ system (Waters Corpo- The content of the six reference compounds in all Aster samples was determined using the UHPLC-PDA system. continually introduced along with the LC stream.…”
Section: Quantitative and Qualitative Analysis By Uhplc-qtof-ms/msmentioning
confidence: 99%