Rapid disinfection by N-halamine polyelectrolytes

Abstract

Two new N-halamine polyelectrolytes were synthesized, characterized, and deposited onto cotton fabric from a water solution using a layer-by-layer assembly technique. The fabrics were rendered biocidal by a dilute household bleach solution and challenged with Grampositive and Gram-negative bacteria. The chlorinated swatches (five bilayer coated) inactivated ~10 6 Staphylococcus aureus and Escherichia coli O157:H7 within only 2 min of contact time. Although the coatings were susceptible to hydrolysis when exposed to repeated washing, the stability of the system was improved by a posttreatment with a cross-linking agent, 3-glycidoxypropyltrimethoxysilane.

Supercritical carbon dioxide application using hydantoin acrylamide for biocidal functionalization of polyester

“…There were additional signals which could be assigned to forming hydantoin ring, methyl group (a) at 1.23 ppm, methylene group (b) at 2.15 ppm, amide (c) at 7.58 ppm, and imide (d) at 10.58 ppm, respectively. NMR signals were in complete accord with that of literature [ [47] , [48] , [49] ].

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Silver sulfadiazine–immobilized celluloses as biocompatible polymeric biocides

“…Consequently, in addition to these three elements, a new peak at 374.6 eV could be observed in the XPS spectrum (Figure 2(b)), which was attributed to the bound silver (Ag 3d5 ). 21,40,42,43 Quantitative analysis of the XPS data indicated that the silver content of this sample was 0.58%, which could provide potent biocidal activities.…”

“…Silver contents on the resulting silver sulfadiazine–immobilized celluloses (SSICs) were determined by XPS, as reported previously. 21 The original cotton celluloses (without SD immobilization) were treated under the same conditions to serve as controls.…”

“…This is the first example of plastic-based “hard” polymeric silver sulfadiazines that could be used in denture materials, bone materials, and other related medical devices. 21…”

“…To date, N-halamines, antimicrobial peptides, quaternary ammonium salts, metal ions, and antibiotics have been employed for antimicrobial modifications of various materials, and some of them have achieved encouraging results. [20][21][22][23][24][25][26][27][28][29][30][31][32] These agents inactivate microorganisms via different mechanisms, and are suitable for different applications. Among these, silver and silver compounds are one of the oldest, most wellknown agents with proven efficacy against a wide range of microorganisms and low toxicity toward human tissue, 27,[33][34][35][36][37][38] making them attractive candidates for a broad range of biomedical and health care-related applications.…”