Vietnam is widely regarded as a success story for its impressive economic growth and poverty reduction in the last few decades. Yet, recent evidence indicates that the country's economic growth has not been uniform. Compiling and analyzing new extensive province‐level data from the Vietnam Household Living Standards Surveys (VHLSSs) spanning 2002 and 2020 and other data sources, we find within‐province inequality to be much larger than between‐province inequality. Furthermore, this inequality gap is rising over time. Despite the country's fast poverty reduction, the poor were increasingly segregated in certain provinces, particularly those with a larger ethnic minority population. We find beneficial impact of economic growth on poverty reduction, but this can depend on inequality levels. We also find greater inequality to have negative effects on economic growth but varying negative effects on different poverty indicators. We also find some supportive evidence for the beneficial impact of economic transitions from agriculture to non‐agriculture. Our results suggest that policy makers in Vietnam should focus on reducing spatial disparities and income inequality to attain sustainable economic development.